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Application of a Mass Confirmation Workflow for Biotherapeutics Screening

 

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Application Note Analysis of Cysteine-Conjugated Antibody Drug Conjugates (ADCs) Using a Native SEC LC-MS Workflow on the SYNAPT XS Henry Shion, Colette Quinn, Scott J. Berger, Ying Qing Yu Waters Corporation This is an Application Brief and does not contain…
Key words
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Application Note Analysis of Antibody siRNA Conjugate Using BioAccord System Henry Shion, Catalin E. Doneanu, Ed Ha, Ying Qing Yu, Weibin Chen Waters Corporation, Angiex, Inc. Biopharmaceutical services at Waters Immerse Innovation and Research Center (www.waters.com/immerse <http://www.waters.com/immerse> ) aim to…
Key words
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[ TECHNOLOGY BRIEF ] Analysis of Antibody Drug Conjugates (ADCs) by Native Mass Spectrometry on the BioAccord System Henry Shion, Ying Qing Yu, and Weibin Chen Waters Corporation, Milford, MA, USA Drug-to-Antibody Ratio (DAR) determination of Lys and Cys conjugated…
Key words
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[ APPLICATION NOTEBOOK ] Multi-Attribute Methods for Biopharmaceutical Analysis Application Notes [ APPLICATION NOTEBOOK ] Introduction The adoption of LC-MS-based multi-attribute method (MAM) analysis for routine monitoring of biotherapeutic variation has progressed greatly over the last five years. The ability…
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