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ADDING COST EFFECTIVE MASS DETECTION FOR IMPROVED PRODUCTIVITY IN OLIGONUCLEOTIDE SCREENING ASSAYSRobert E. Birdsall, Sean M. McCarthy, Scott J. Berger, Maki Terasaki, Kenji Hiroseand Ying Qing YuBiopharmaceutical Business Team, Waters Corporation, Milford, MA and Tokyo, JapanTUVAbsorbance (A.U.)INTRODUCTIONResearch into therapeutic oligonucleotides...
Key words
qda, qdapromass, promassacquity, acquityproductivity, productivitymass, massoligonucleotides, oligonucleotidesspectrum, spectrumscreening, screeningstraightforward, straightforwardassays, assaysdata, datathroughput, throughputoligonucleotide, oligonucleotidecharge, chargestate
[ APPLICATION NOTEBOOK ]APPLICATION SOLUTIONS FOROLIGONUCLEOTIDES Table of ContentsIntroduction – UPLC Analysis of Synthetic Oligonucleotides......................................................................................................................... 4[ HPLC & UPLC Separations ]Real-Time Analysis of RNAi Duplexes ....................................................................................................................................................................... 8Semi-Preparative Scale Single-Stranded RNA Purification .......................................................................................................................... 11Oligonucleotide Separation Technology: Synthesis Challenges and HPLC Isolation Options...
Key words
oligonucleotides, oligonucleotidesoligonucleotide, oligonucleotideuplc, uplcacquity, acquityrnai, rnaiost, ostduplex, duplexpromass, promassduplexes, duplexessirna, sirnawaters, watersqda, qdarna, rnaanalysis, analysispairing
Adding Mass Detection to Synthetic Oligonucleotide Analyseswith the ACQUITY QDa DetectorRobert E. Birdsall and Ying Qing YuWaters Corporation, Milford, MA, USAA P P L I C AT I O N B E N E F I T S■■Addition of mass...
Key words
qda, qdaacquity, acquityoligonucleotide, oligonucleotidedetector, detectorrplc, rplcmass, masssynthetic, syntheticanalyses, analysesoligonucleotides, oligonucleotidestuv, tuvadding, addingmeans, meansdetection, detectionuplc, uplcphases
High-throughput Screening of Oligonucleotides for Identity and PurityAssessment Using the ACQUITY QDa Detector and ProMass for MassLynxRobert E. Birdsall and Ying Qing YuWaters Corporation, Milford, MA, USAA P P L I C AT I O N B E N E...
Key words
oligonucleotides, oligonucleotidespromass, promassacquity, acquityqda, qdapurity, puritystrand, strandidentity, identityassessment, assessmentthroughput, throughputdata, datasynthetic, syntheticmass, massscreening, screeningmasslynx, masslynxformat
 

Similar PDF

ADDING COST EFFECTIVE MASS DETECTION FOR IMPROVED PRODUCTIVITY IN OLIGONUCLEOTIDE SCREENING ASSAYSRobert E. Birdsall, Sean M. McCarthy, Scott J. Berger, Maki Terasaki, Kenji Hiroseand Ying Qing YuBiopharmaceutical Business Team, Waters Corporation, Milford, MA and Tokyo, JapanTUVAbsorbance (A.U.)INTRODUCTIONResearch into therapeutic oligonucleotides...
Key words
qda, qdapromass, promassacquity, acquityproductivity, productivitymass, massoligonucleotides, oligonucleotidesspectrum, spectrumscreening, screeningstraightforward, straightforwardassays, assaysdata, datathroughput, throughputoligonucleotide, oligonucleotidecharge, chargestate
[ APPLICATION NOTEBOOK ]APPLICATION SOLUTIONS FOROLIGONUCLEOTIDES Table of ContentsIntroduction – UPLC Analysis of Synthetic Oligonucleotides......................................................................................................................... 4[ HPLC & UPLC Separations ]Real-Time Analysis of RNAi Duplexes ....................................................................................................................................................................... 8Semi-Preparative Scale Single-Stranded RNA Purification .......................................................................................................................... 11Oligonucleotide Separation Technology: Synthesis Challenges and HPLC Isolation Options...
Key words
oligonucleotides, oligonucleotidesoligonucleotide, oligonucleotideuplc, uplcacquity, acquityrnai, rnaiost, ostduplex, duplexpromass, promassduplexes, duplexessirna, sirnawaters, watersqda, qdarna, rnaanalysis, analysispairing
Adding Mass Detection to Synthetic Oligonucleotide Analyseswith the ACQUITY QDa DetectorRobert E. Birdsall and Ying Qing YuWaters Corporation, Milford, MA, USAA P P L I C AT I O N B E N E F I T S■■Addition of mass...
Key words
qda, qdaacquity, acquityoligonucleotide, oligonucleotidedetector, detectorrplc, rplcmass, masssynthetic, syntheticanalyses, analysesoligonucleotides, oligonucleotidestuv, tuvadding, addingmeans, meansdetection, detectionuplc, uplcphases
High-throughput Screening of Oligonucleotides for Identity and PurityAssessment Using the ACQUITY QDa Detector and ProMass for MassLynxRobert E. Birdsall and Ying Qing YuWaters Corporation, Milford, MA, USAA P P L I C AT I O N B E N E...
Key words
oligonucleotides, oligonucleotidespromass, promassacquity, acquityqda, qdapurity, puritystrand, strandidentity, identityassessment, assessmentthroughput, throughputdata, datasynthetic, syntheticmass, massscreening, screeningmasslynx, masslynxformat
 

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