Analysis of Antibody Fragment-Drug Conjugates Using an Agilent AdvanceBio SEC 120 Å 1.9 μm PEEK-Lined ColumnApplications | 2021 | Agilent TechnologiesInstrumentation
Consumables, HPLC, LC/TOF, LC/HRMS, LC/MS, LC/MS/MS, LC columns
Industries
Pharma & Biopharma
Manufacturer
Agilent Technologies
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Application NotePharma & BiopharmaSensitive Native Mass Spectrometryof Macromolecules Using StandardFlow LC/MSAuthorDavid L. WongAgilent Technologies, Inc.AbstractNative mass spectrometry can be used for a variety of protein-based applications,such as protein-protein interaction, protein-ligand binding, protein complexstructures, protein folding and antibody-drug conjugates. Most of...
Key words
native, nativeprotein, proteincounts, countsintact, intactdeconvoluted, deconvolutedmyoglobin, myoglobinapomyoglobin, apomyoglobinamu, amucharge, chargemass, masscomplexes, complexesheme, hemeholomyoglobin, holomyoglobindenatured, denaturedtetramer
Application NotePharma & BiopharmaMass Spectrometric Characterizationof Antibody-siRNA Conjugates usingthe Agilent 6545XT AdvanceBioLC/Q‑TOFAuthorDavid L. WongAgilent Technologies, Inc.AbstractSmall interfering RNAs (siRNAs) are a promising type of RNA-based therapeuticdrugs that demonstrate effectiveness on gene silencing through RNA interference(RNAi). However, due to the chemical...
Key words
sirna, sirnamab, mabconjugates, conjugatesintact, intactcounts, countsdeglycosylated, deglycosylatednative, nativedeconvoluted, deconvolutedamu, amuadvancebio, advancebiomass, massrna, rnaantibody, antibodysirnas, sirnaslinker
Analysis of Antibody-Drug ConjugatesUsing Size Exclusion Chromatographyand Mass SpectrometryApplication NoteBiologics and BiosimilarsAuthorAbstractSonja SchneiderRecombinant monoclonal antibodies (mAbs) have emerged as importantAgilent Technologies, Inc.therapeutic agents for the treatment of different diseases. This technology hasWaldbronn, Germanybeen extended by the development of antibody drug...
Key words
trastuzumab, trastuzumabadcs, adcsadc, adcemtansine, emtansinedeconvoluted, deconvolutedcounts, countsdrug, drugdeglycosylated, deglycosylatedamu, amumass, masssec, secmabs, mabsbuffer, bufferspectrum, spectrumexclusion
Size Exclusion Chromatography/Mass Spectrometry Analysis ofAntibody Drug Conjugates Using theAgilent 1260 Infinity II Bio-Inert LCApplication NoteBiologics & BiosimilarsAuthorAbstractSonja SchneiderRecombinant monoclonal antibodies (mAbs) have emerged as importantAgilent Technologies, Inc.therapeutic agents for the treatment of different diseases1. These biotherapeuticsWaldbronn, Germanyhave been extended...
Key words
adcs, adcsdeconvoluted, deconvolutedadc, adctrastuzumab, trastuzumabdeglycosylated, deglycosylatedmass, massdrug, drugcounts, countsantibody, antibodysec, seclinker, linkerspectrum, spectrumcharge, chargedar, darconjugates

Analysis of Antibody Fragment-Drug Conjugates Using an Agilent AdvanceBio SEC 120 Å 1.9 μm PEEK-Lined ColumnApplications | 2021 | Agilent TechnologiesInstrumentation
Consumables, HPLC, LC/TOF, LC/HRMS, LC/MS, LC/MS/MS, LC columns
Industries
Pharma & Biopharma
Manufacturer
Agilent Technologies
Key words

 

Similar PDF

Toggle
Application NotePharma & BiopharmaSensitive Native Mass Spectrometryof Macromolecules Using StandardFlow LC/MSAuthorDavid L. WongAgilent Technologies, Inc.AbstractNative mass spectrometry can be used for a variety of protein-based applications,such as protein-protein interaction, protein-ligand binding, protein complexstructures, protein folding and antibody-drug conjugates. Most of...
Key words
native, nativeprotein, proteincounts, countsintact, intactdeconvoluted, deconvolutedmyoglobin, myoglobinapomyoglobin, apomyoglobinamu, amucharge, chargemass, masscomplexes, complexesheme, hemeholomyoglobin, holomyoglobindenatured, denaturedtetramer
Application NotePharma & BiopharmaMass Spectrometric Characterizationof Antibody-siRNA Conjugates usingthe Agilent 6545XT AdvanceBioLC/Q‑TOFAuthorDavid L. WongAgilent Technologies, Inc.AbstractSmall interfering RNAs (siRNAs) are a promising type of RNA-based therapeuticdrugs that demonstrate effectiveness on gene silencing through RNA interference(RNAi). However, due to the chemical...
Key words
sirna, sirnamab, mabconjugates, conjugatesintact, intactcounts, countsdeglycosylated, deglycosylatednative, nativedeconvoluted, deconvolutedamu, amuadvancebio, advancebiomass, massrna, rnaantibody, antibodysirnas, sirnaslinker
Analysis of Antibody-Drug ConjugatesUsing Size Exclusion Chromatographyand Mass SpectrometryApplication NoteBiologics and BiosimilarsAuthorAbstractSonja SchneiderRecombinant monoclonal antibodies (mAbs) have emerged as importantAgilent Technologies, Inc.therapeutic agents for the treatment of different diseases. This technology hasWaldbronn, Germanybeen extended by the development of antibody drug...
Key words
trastuzumab, trastuzumabadcs, adcsadc, adcemtansine, emtansinedeconvoluted, deconvolutedcounts, countsdrug, drugdeglycosylated, deglycosylatedamu, amumass, masssec, secmabs, mabsbuffer, bufferspectrum, spectrumexclusion
Size Exclusion Chromatography/Mass Spectrometry Analysis ofAntibody Drug Conjugates Using theAgilent 1260 Infinity II Bio-Inert LCApplication NoteBiologics & BiosimilarsAuthorAbstractSonja SchneiderRecombinant monoclonal antibodies (mAbs) have emerged as importantAgilent Technologies, Inc.therapeutic agents for the treatment of different diseases1. These biotherapeuticsWaldbronn, Germanyhave been extended...
Key words
adcs, adcsdeconvoluted, deconvolutedadc, adctrastuzumab, trastuzumabdeglycosylated, deglycosylatedmass, massdrug, drugcounts, countsantibody, antibodysec, seclinker, linkerspectrum, spectrumcharge, chargedar, darconjugates
 

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