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Analysis of Cysteine-LinkedAntibody Drug ConjugatesUsing Hydrophobic Interaction Chromatography on theAgilent 1260 Infinity II Bio-inert LCApplication NoteBiologics and BiosimilarsAuthorAbstractSonja SchneiderHydrophobic interaction chromatography (HIC) is frequently used for theAgilent Technologies, Inc.determination of drug-to-antibody ratio (DAR) of cysteine-linked antibody drugWaldbronn, Germanyconjugates (ADCs). The...
Key words
brentuximab, brentuximabvedotin, vedotindar, darhic, hicdrug, drugantibody, antibodyhydrophobic, hydrophobicmmae, mmaeadcs, adcsadc, adcinteraction, interactiontige, tigemab, mablinked, linkedcleavable
Antibody-Drug Conjugate (ADC) Drug-to-Antibody Ratio (DAR)Analysis in Serum Using IA-LC-HRMSArmand Ngounou and Mark WronaWaters Corporation, Milford, MA, USAAPPLICATION BENEFITS■■■■Robust and reliable IA-UPLC-HRMSAntibody-drug conjugates (ADCs) are comprised of a cytotoxic drugmethod for the qualitative analysisattached at several locations to a monoclonal...
Key words
dar, darantibody, antibodydrug, drugadc, adcserum, serumconjugate, conjugatehrms, hrmslockspray, lockspraybiotransformation, biotransformationratio, ratioimmunoaffinity, immunoaffinityuplc, uplcadcs, adcsapplication, applicationload
Analytical Scale Native SEC-MS for Antibody-Drug Conjugates(ADCs) CharacterizationHenry Shion, Ying Qing Yu, and Weibin ChenWaters Corporation, Milford, MA, USAAPPLICATION BENEFITS■■■■■■An improved native mass spectrometrywith analytical scale Size ExclusionChromatography (SEC) method isdeveloped for characterization ofcysteine-conjugated and lysineconjugated ADCs.This improved method offers...
Key words
adcs, adcsnative, nativesec, secdar, dardrug, drugantibody, antibodyhic, hicscale, scaleconjugated, conjugatedcharacterization, characterizationconjugates, conjugatesprotein, proteinuplc, uplcvion, vionconjugation
Analysis of Monoclonal Antibodies
2016|Agilent Technologies|Aplikace
Analysis of Monoclonal AntibodiesUsing Multiple Heart-cutting HydrophobicInteraction/Reversed Phase 2D-LC/MSApplication NoteBiotherapeutics & BiologicsAuthorAbstractGregory StaplesHydrophobic interaction chromatography (HIC) is a popular approach for bothAgilent Technologies, Inc.downstream processing and analytical scale analysis of monoclonal antibodies(mAbs). In the latter case, HIC is a useful...
Key words
hic, hicamu, amudeconvoluted, deconvolutedmab, mabmass, massheart, heartseparation, separationcutting, cuttingdesalting, desaltinglys, lysmhc, mhclinked, linkedmabs, mabstbhp, tbhpmobile
 

Similar PDF

Analysis of Cysteine-LinkedAntibody Drug ConjugatesUsing Hydrophobic Interaction Chromatography on theAgilent 1260 Infinity II Bio-inert LCApplication NoteBiologics and BiosimilarsAuthorAbstractSonja SchneiderHydrophobic interaction chromatography (HIC) is frequently used for theAgilent Technologies, Inc.determination of drug-to-antibody ratio (DAR) of cysteine-linked antibody drugWaldbronn, Germanyconjugates (ADCs). The...
Key words
brentuximab, brentuximabvedotin, vedotindar, darhic, hicdrug, drugantibody, antibodyhydrophobic, hydrophobicmmae, mmaeadcs, adcsadc, adcinteraction, interactiontige, tigemab, mablinked, linkedcleavable
Antibody-Drug Conjugate (ADC) Drug-to-Antibody Ratio (DAR)Analysis in Serum Using IA-LC-HRMSArmand Ngounou and Mark WronaWaters Corporation, Milford, MA, USAAPPLICATION BENEFITS■■■■Robust and reliable IA-UPLC-HRMSAntibody-drug conjugates (ADCs) are comprised of a cytotoxic drugmethod for the qualitative analysisattached at several locations to a monoclonal...
Key words
dar, darantibody, antibodydrug, drugadc, adcserum, serumconjugate, conjugatehrms, hrmslockspray, lockspraybiotransformation, biotransformationratio, ratioimmunoaffinity, immunoaffinityuplc, uplcadcs, adcsapplication, applicationload
Analytical Scale Native SEC-MS for Antibody-Drug Conjugates(ADCs) CharacterizationHenry Shion, Ying Qing Yu, and Weibin ChenWaters Corporation, Milford, MA, USAAPPLICATION BENEFITS■■■■■■An improved native mass spectrometrywith analytical scale Size ExclusionChromatography (SEC) method isdeveloped for characterization ofcysteine-conjugated and lysineconjugated ADCs.This improved method offers...
Key words
adcs, adcsnative, nativesec, secdar, dardrug, drugantibody, antibodyhic, hicscale, scaleconjugated, conjugatedcharacterization, characterizationconjugates, conjugatesprotein, proteinuplc, uplcvion, vionconjugation
Analysis of Monoclonal Antibodies
2016|Agilent Technologies|Aplikace
Analysis of Monoclonal AntibodiesUsing Multiple Heart-cutting HydrophobicInteraction/Reversed Phase 2D-LC/MSApplication NoteBiotherapeutics & BiologicsAuthorAbstractGregory StaplesHydrophobic interaction chromatography (HIC) is a popular approach for bothAgilent Technologies, Inc.downstream processing and analytical scale analysis of monoclonal antibodies(mAbs). In the latter case, HIC is a useful...
Key words
hic, hicamu, amudeconvoluted, deconvolutedmab, mabmass, massheart, heartseparation, separationcutting, cuttingdesalting, desaltinglys, lysmhc, mhclinked, linkedmabs, mabstbhp, tbhpmobile
 

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