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Utilization of the ACQUITY PREMIER System and Column for Improved Oligonucleotide Bioanalytical Chromatographic Performance

 

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Application Note Improved Oligonucleotide SPE-LC-MS Analysis Using MaxPeak High Performance Technology Kathryn Brennan, Mary Trudeau Lame, Michael Donegan, Paul D. Rainville Waters Corporation Abstract The demand for highly selective and sensitive LC-MS bioanalytical assays in support of research and development…
Key words
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Application Note Sensitive LC-MS/MS Bioanalytical Quantitation of Antisense Oligonucleotides Suma Veeramachineni, Mark D. Wrona Waters Corporation Abstract This application demonstrates the quantitative and qualitative capabilities of the Waters™ Xevo™ TQ Absolute Tandem Quadrupole Mass Spectrometer (MS/MS) and its suitability for…
Key words
antisense, antisenseoligonucleotides, oligonucleotidesbioanalytical, bioanalyticalsensitive, sensitivequantitation, quantitationpremier, premiertandem, tandemacquity, acquityabsolute, absolutewaters, watershps, hpsmaxpeak, maxpeakoligonucleotide, oligonucleotidehuman, humansurfaces
Improving LC-MS/MS Bioanalytical Quantitation of Oligonucleotides using New High Performance Tandem Quadrupole Mass Spectrometer Suma Veeramachineni1; Suraj Dhungana1; Ying-Qing Yu1; Mark Wrona1; 1Waters Corporation, Milford, MA Introduction Results Improving LC-MS/MS bioanalytical performance especially for ESI negative analytes has been of…
Key words
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Application Note Improving Recovery and Quantitation of Oligonucleotide Impurities Using ACQUITY PREMIER with MaxPeak HPS Technology Brooke M. Koshel, Robert E. Birdsall, Ying Qing Yu Waters Corporation Abstract Ion-pair reversed-phase chromatography is a commonly used technique for the separation of…
Key words
premier, premieroligonucleotide, oligonucleotideacquity, acquitymaxpeak, maxpeakhps, hpssystem, systemtechnology, technologyoligonucleotides, oligonucleotidesimpurities, impuritiesconventional, conventionalsurfaces, surfacespassivation, passivationminutes, minutesusing, usingmetal
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