Fast Separation of Monoclonal Antibody and Dimer by SEC with Agilent Bio SECApplications | 2011 | Agilent TechnologiesInstrumentation Consumables, LC columns, GPC/SECIndustriesPharma & BiopharmaManufacturerAgilent TechnologiesKey wordsdimer, eluent, salted, monomer, monoclonal, antibody, salt, competitor, percentage, agilent, flow, rate, column, efficiency, mab, exclusion, ratio, resolution, sec, backpressures, revealing, detection, tim, suit, aggregation, eluents, therapeutics, injection, usa, fast, rice, analysis, conditions, biopharma, without, separation, concern, bio, helps, shorter, maintaining, sample, dependent, become, chromatography, rates, consequential, widely, incidental, liable
Aggregate and Fragment Analysis - Agilent BioHPLC Columns Application Compendium
Agilent-NISTmAbAggregate andFragment AnalysisAgilent BioHPLC ColumnsApplication CompendiumContentsAgilent-NISTmAb Standard (P/N 5191-5744; 5191-5745) was aliquoted fromNISTmAb RM 8671 batch. Quality control (QC) testing is performed usingAgilent LC-MS system. QC batch release test includes aggregate profile, chargevariants and intact mass information. A certificate of...
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Mobile Phase Optimization in SEC Method Development
Application NotePharma & BiopharmaMobile Phase Optimization in SECMethod DevelopmentAuthorRichard HurteauAgilent Technologies, Inc.,Wilmington, DE, USAAbstractAggregation of monoclonal antibody (mAb) products has an adverse effect ontheir efficacy as therapeutic agents. Size exclusion chromatography (SEC) is ahighly effective method for the detection of...
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Agilent AdvanceBio SEC Columns for Aggregate Analysis: Instrument Compatibility
2017|Agilent Technologies|Technical notes
Agilent AdvanceBio SEC Columnsfor Aggregate Analysis: InstrumentCompatibilityTechnical OverviewIntroductionAgilent AdvanceBio SEC columns are a new family of size exclusion chromatography(SEC) columns packed with 2.7 µm particles of a unique, low binding, polymer coatedsilica stationary phase. This technology provides minimal nonspecific interactions,and...
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Helpful ‘Hints’ for Protein SEC Success
Helpful ‘Hints’ for ProteinSEC SuccessJean LaneApplications EngineerLC columns and consumables technical supportMay 27, 20201Outline for TalkGetting started•SEC definition, common terminology, and why use it?•Considerations for selecting an SEC column- Pain Points/Challenges for SEC- Importance of Pore Size and Particle Size...
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