Characterization of mAb AggregationApplications | 2020 | Agilent TechnologiesInstrumentationGPC/SECIndustriesPharma & BiopharmaManufacturerAgilent TechnologiesKey wordsaggregate, aggregation, stressed, mab, freeze, thaw, samples, sec, aggregates, stress, formation, index, were, agilent, method, monomer, winuv, absorbance, control, cycles, contrasts, different, forms, repeated, subject, log, unstressed, menon, sreelakshmy, biosamples, thermomixer, exclusion, thawing, placed, cuvette, antibody, sample, nondestructive, rectangular, cary, insets, measurements, data, xenon, carried, area, quick, thermal, spectral, presence
Similar PDF
High-Throughput Fluorescence-Based mAbs Aggregation Analysis Workflow
2020|Agilent Technologies|Applications
Application NoteBiologicsHigh-Throughput Fluorescence-BasedmAbs Aggregation Analysis WorkflowEfficiency gains when using fluorescence analysisto complement size exclusion chromatographyAuthorsIntroductionBrian LiauAgilent Technologies, Inc.Modern biologics development relies on the screening of 100s - 1000s ofmonoclonal antibody (mAb) variants to identify lead development candidates withoptimal properties such...
Key words
aggregation, aggregationfluorescence, fluorescencepepbops, pepbopsmabs, mabsestimates, estimatesrituximab, rituximabskim, skimsypro, syprotrastuzumab, trastuzumabmab, mabans, ansreader, readerantibody, antibodyreject, rejectbuffer
High-throughput and Sensitive Size Exclusion Chromatography (SEC) of Biologics Using Agilent AdvanceBio SEC Columns
2017|Agilent Technologies|Applications
High-throughput and Sensitive SizeExclusion Chromatography (SEC) ofBiologics Using Agilent AdvanceBioSEC ColumnsAgilent AdvanceBio SEC 300 Å, 2.7 µm columnsApplication noteBio-PharmaceuticalAuthorAbstractM. Sundaram PalaniswamyMonoclonal antibody (mAb) aggregation can arise due to multiple mechanismsAgilent Technologies Inc.during cell culture, harvest, purification, storage, and filling. Size...
Key words
adc, adcherceptin, herceptinmau, mauadvancebio, advancebiosec, secmonomer, monomeraggregate, aggregatemab, mabaggregates, aggregatesoverlay, overlayreplicates, replicatesstressed, stresseddegraded, degradedpreservative, preservativecolumns
T he Analysis of Multimeric Monoclonal Antibody Aggregates by Size-Exclusion UPLC
2013|Waters|Applications
The Analysis of Multimeric Monoclonal Antibody Aggregatesby Size-Exclusion UPLCStephan Koza, Matthew Lauber, and Kenneth J. FountainWaters Corporation, Milford, MA, USAA P P L I C AT I O N B E N E F I T S■■ACQUITY UPLC SEC Technology...
Key words
multimeric, multimericmultimers, multimersdimer, dimeraggregates, aggregatesuplc, uplctrimer, trimerexclusion, exclusionmonoclonal, monoclonalmonomer, monomerdimeric, dimericsize, sizemab, mabantibody, antibodyaggregate, aggregateforms
Agilent Biocolumns - Aggregate/Fragment Analysis - Application Compendium
2021|Agilent Technologies|Guides
Agilent BiocolumnsAggregate/Fragment AnalysisApplication CompendiumContentsBackground2Getting Started3How to Guide - Size Exclusion Chromatography for BiomoleculeAnalysis - 5991-3651EN 4Featured Application NotesElevate Your mAb Aggregate Analysis - 5994-2709EN12222High-Resolution, High-Throughput Size Exclusion ChromatographyAnalysis of Monoclonal Antibodies - 5994-0828EN29Sensitive Native Mass Spectrometry of MacromoleculesUsing Standard Flow LC/MS...
Key words
return, returnsection, sectioncontents, contentsmau, mausec, secinsulin, insulinmin, minsize, sizeprotein, proteinmonomer, monomeradvancebio, advancebiotime, timeexclusion, exclusionaggregates, aggregatesaggregate