Characterization of mAb AggregationApplications | 2020 | Agilent TechnologiesInstrumentation
GPC/SEC
Industries
Pharma & Biopharma
Manufacturer
Agilent Technologies
Key words

 

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Application NoteBiologicsHigh-Throughput Fluorescence-BasedmAbs Aggregation Analysis WorkflowEfficiency gains when using fluorescence analysisto complement size exclusion chromatographyAuthorsIntroductionBrian LiauAgilent Technologies, Inc.Modern biologics development relies on the screening of 100s - 1000s ofmonoclonal antibody (mAb) variants to identify lead development candidates withoptimal properties such...
Key words
aggregation, aggregationfluorescence, fluorescencepepbops, pepbopsmabs, mabsestimates, estimatesrituximab, rituximabskim, skimsypro, sypromab, mabtrastuzumab, trastuzumabans, ansreader, readerantibody, antibodyreject, rejectmicroplate
Separate and Quantify RituximabAggregates and Fragments withHigh-Resolution SECThe Agilent 1260 Infinity Bio-Inert Quaternary LC Systemand the AdvanceBio SEC 300Å, 2.7 µm ColumnApplication NoteBiologics and BiosimilarsAuthorAbstractM.Sundaram PalaniswamyMonoclonal antibody aggregation can arise from multiple mechanisms, includingAgilent Technologies Pvt Ltdproduct and environmental factors....
Key words
innovator, innovatoraggregates, aggregatesbiosimilar, biosimilarrituximab, rituximabmau, mauintact, intactfragments, fragmentsstressed, stressedmabs, mabssec, secstress, stressadvancebio, advancebiomonomer, monomerarea, areaaggregation
High-throughput and Sensitive SizeExclusion Chromatography (SEC) ofBiologics Using Agilent AdvanceBioSEC ColumnsAgilent AdvanceBio SEC 300 Å, 2.7 µm columnsApplication noteBio-PharmaceuticalAuthorAbstractM. Sundaram PalaniswamyMonoclonal antibody (mAb) aggregation can arise due to multiple mechanismsAgilent Technologies Inc.during cell culture, harvest, purification, storage, and filling. Size...
Key words
adc, adcherceptin, herceptinmau, mauadvancebio, advancebiomonomer, monomersec, secaggregate, aggregatemab, mabaggregates, aggregatesoverlay, overlayreplicates, replicatesstressed, stresseddegraded, degradedpreservative, preservativecolumns
The Analysis of Multimeric Monoclonal Antibody Aggregatesby Size-Exclusion UPLCStephan Koza, Matthew Lauber, and Kenneth J. FountainWaters Corporation, Milford, MA, USAA P P L I C AT I O N B E N E F I T S■■ACQUITY UPLC SEC Technology...
Key words
multimeric, multimericmultimers, multimersdimer, dimeraggregates, aggregatesuplc, uplctrimer, trimermonoclonal, monoclonalexclusion, exclusiondimeric, dimericmonomer, monomermab, mabantibody, antibodysize, sizeaggregate, aggregateforms

Characterization of mAb AggregationApplications | 2020 | Agilent TechnologiesInstrumentation
GPC/SEC
Industries
Pharma & Biopharma
Manufacturer
Agilent Technologies
Key words

 

Similar PDF

Toggle
Application NoteBiologicsHigh-Throughput Fluorescence-BasedmAbs Aggregation Analysis WorkflowEfficiency gains when using fluorescence analysisto complement size exclusion chromatographyAuthorsIntroductionBrian LiauAgilent Technologies, Inc.Modern biologics development relies on the screening of 100s - 1000s ofmonoclonal antibody (mAb) variants to identify lead development candidates withoptimal properties such...
Key words
aggregation, aggregationfluorescence, fluorescencepepbops, pepbopsmabs, mabsestimates, estimatesrituximab, rituximabskim, skimsypro, sypromab, mabtrastuzumab, trastuzumabans, ansreader, readerantibody, antibodyreject, rejectmicroplate
Separate and Quantify RituximabAggregates and Fragments withHigh-Resolution SECThe Agilent 1260 Infinity Bio-Inert Quaternary LC Systemand the AdvanceBio SEC 300Å, 2.7 µm ColumnApplication NoteBiologics and BiosimilarsAuthorAbstractM.Sundaram PalaniswamyMonoclonal antibody aggregation can arise from multiple mechanisms, includingAgilent Technologies Pvt Ltdproduct and environmental factors....
Key words
innovator, innovatoraggregates, aggregatesbiosimilar, biosimilarrituximab, rituximabmau, mauintact, intactfragments, fragmentsstressed, stressedmabs, mabssec, secstress, stressadvancebio, advancebiomonomer, monomerarea, areaaggregation
High-throughput and Sensitive SizeExclusion Chromatography (SEC) ofBiologics Using Agilent AdvanceBioSEC ColumnsAgilent AdvanceBio SEC 300 Å, 2.7 µm columnsApplication noteBio-PharmaceuticalAuthorAbstractM. Sundaram PalaniswamyMonoclonal antibody (mAb) aggregation can arise due to multiple mechanismsAgilent Technologies Inc.during cell culture, harvest, purification, storage, and filling. Size...
Key words
adc, adcherceptin, herceptinmau, mauadvancebio, advancebiomonomer, monomersec, secaggregate, aggregatemab, mabaggregates, aggregatesoverlay, overlayreplicates, replicatesstressed, stresseddegraded, degradedpreservative, preservativecolumns
The Analysis of Multimeric Monoclonal Antibody Aggregatesby Size-Exclusion UPLCStephan Koza, Matthew Lauber, and Kenneth J. FountainWaters Corporation, Milford, MA, USAA P P L I C AT I O N B E N E F I T S■■ACQUITY UPLC SEC Technology...
Key words
multimeric, multimericmultimers, multimersdimer, dimeraggregates, aggregatesuplc, uplctrimer, trimermonoclonal, monoclonalexclusion, exclusiondimeric, dimericmonomer, monomermab, mabantibody, antibodysize, sizeaggregate, aggregateforms
 

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