Characterization of mAb Aggregation | LabRulez LCMS
 

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Separate and Quantify RituximabAggregates and Fragments withHigh-Resolution SECThe Agilent 1260 Infinity Bio-Inert Quaternary LC Systemand the AdvanceBio SEC 300Å, 2.7 µm ColumnApplication NoteBiologics and BiosimilarsAuthorAbstractM.Sundaram PalaniswamyMonoclonal antibody aggregation can arise from multiple mechanisms, includingAgilent Technologies Pvt Ltdproduct and environmental factors....
Key words
innovator, innovatoraggregates, aggregatesbiosimilar, biosimilarrituximab, rituximabmau, mauintact, intactfragments, fragmentsstressed, stressedmabs, mabssec, secstress, stressadvancebio, advancebiomonomer, monomerarea, areaaggregation
High-throughput and Sensitive SizeExclusion Chromatography (SEC) ofBiologics Using Agilent AdvanceBioSEC ColumnsAgilent AdvanceBio SEC 300 Å, 2.7 µm columnsApplication noteBio-PharmaceuticalAuthorAbstractM. Sundaram PalaniswamyMonoclonal antibody (mAb) aggregation can arise due to multiple mechanismsAgilent Technologies Inc.during cell culture, harvest, purification, storage, and filling. Size...
Key words
adc, adcherceptin, herceptinmau, mauadvancebio, advancebiosec, secmonomer, monomeraggregate, aggregatemab, mabaggregates, aggregatesoverlay, overlayreplicates, replicatesstressed, stresseddegraded, degradedpreservative, preservativecolumns
The Analysis of Multimeric Monoclonal Antibody Aggregatesby Size-Exclusion UPLCStephan Koza, Matthew Lauber, and Kenneth J. FountainWaters Corporation, Milford, MA, USAA P P L I C AT I O N B E N E F I T S■■ACQUITY UPLC SEC Technology...
Key words
multimeric, multimericdimer, dimermultimers, multimersaggregates, aggregatesuplc, uplctrimer, trimerexclusion, exclusionmonoclonal, monoclonalmonomer, monomerdimeric, dimericsize, sizemab, mabantibody, antibodyaggregate, aggregateforms
Agilent BiocolumnsAggregate/Fragment AnalysisApplication Compendium ContentsBackground2Getting Started3How to Guide - Size Exclusion Chromatography for BiomoleculeAnalysis - 5991-3651EN 4Featured Application NotesElevate Your mAb Aggregate Analysis - 5994-2709EN12222High-Resolution, High-Throughput Size Exclusion ChromatographyAnalysis of Monoclonal Antibodies - 5994-0828EN29Sensitive Native Mass Spectrometry of MacromoleculesUsing Standard Flow LC/MS...
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return, returnsection, sectioncontents, contentsmau, mausec, secinsulin, insulinmin, minsize, sizeprotein, proteinmonomer, monomeradvancebio, advancebiotime, timeexclusion, exclusionaggregates, aggregatesaggregate
 

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Separate and Quantify RituximabAggregates and Fragments withHigh-Resolution SECThe Agilent 1260 Infinity Bio-Inert Quaternary LC Systemand the AdvanceBio SEC 300Å, 2.7 µm ColumnApplication NoteBiologics and BiosimilarsAuthorAbstractM.Sundaram PalaniswamyMonoclonal antibody aggregation can arise from multiple mechanisms, includingAgilent Technologies Pvt Ltdproduct and environmental factors....
Key words
innovator, innovatoraggregates, aggregatesbiosimilar, biosimilarrituximab, rituximabmau, mauintact, intactfragments, fragmentsstressed, stressedmabs, mabssec, secstress, stressadvancebio, advancebiomonomer, monomerarea, areaaggregation
High-throughput and Sensitive SizeExclusion Chromatography (SEC) ofBiologics Using Agilent AdvanceBioSEC ColumnsAgilent AdvanceBio SEC 300 Å, 2.7 µm columnsApplication noteBio-PharmaceuticalAuthorAbstractM. Sundaram PalaniswamyMonoclonal antibody (mAb) aggregation can arise due to multiple mechanismsAgilent Technologies Inc.during cell culture, harvest, purification, storage, and filling. Size...
Key words
adc, adcherceptin, herceptinmau, mauadvancebio, advancebiosec, secmonomer, monomeraggregate, aggregatemab, mabaggregates, aggregatesoverlay, overlayreplicates, replicatesstressed, stresseddegraded, degradedpreservative, preservativecolumns
The Analysis of Multimeric Monoclonal Antibody Aggregatesby Size-Exclusion UPLCStephan Koza, Matthew Lauber, and Kenneth J. FountainWaters Corporation, Milford, MA, USAA P P L I C AT I O N B E N E F I T S■■ACQUITY UPLC SEC Technology...
Key words
multimeric, multimericdimer, dimermultimers, multimersaggregates, aggregatesuplc, uplctrimer, trimerexclusion, exclusionmonoclonal, monoclonalmonomer, monomerdimeric, dimericsize, sizemab, mabantibody, antibodyaggregate, aggregateforms
Agilent BiocolumnsAggregate/Fragment AnalysisApplication Compendium ContentsBackground2Getting Started3How to Guide - Size Exclusion Chromatography for BiomoleculeAnalysis - 5991-3651EN 4Featured Application NotesElevate Your mAb Aggregate Analysis - 5994-2709EN12222High-Resolution, High-Throughput Size Exclusion ChromatographyAnalysis of Monoclonal Antibodies - 5994-0828EN29Sensitive Native Mass Spectrometry of MacromoleculesUsing Standard Flow LC/MS...
Key words
return, returnsection, sectioncontents, contentsmau, mausec, secinsulin, insulinmin, minsize, sizeprotein, proteinmonomer, monomeradvancebio, advancebiotime, timeexclusion, exclusionaggregates, aggregatesaggregate
 

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