Lipid Nanoparticle Compositional Analysis Using Charged Surface Hybrid Phenyl-Hexyl Separation With Evaporative Light Scattering Detection | LabRulez LCMS_EN
 

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Application NoteRapid Analysis of Lipid NanoparticleComponents Using BioAccord LC-MS SystemGiorgis Isaac, Nilini Ranbaduge, Bonnie A. Alden, Colette Quinn, Weibin Chen, Robert S. PlumbWaters CorporationAbstractThe recent success of mRNA vaccines for COVID-19 is in part due to the development of lipid...
Key words
lipid, lipidbioaccord, bioaccordlnp, lnpnanoparticle, nanoparticleunifi, unifilnps, lnpsclasses, classescompare, comparedeliver, deliverunknown, unknownimpurities, impuritiesfactorial, factorialthereof, thereoffunction, functionfractional
LIPID NANOPARTICLES—GET TO KNOW THEM ANALYTICALLYGiorgis Isaac; Nilini Ranbaduge; Bonnie Alden; Colette Quinn; Weibin ChenWaters Corporation, Milford, MA 01757INTRODUCTIONLipid Nanoparticles (LNPs)The recent success of mRNA vaccines is largely due to their abilityto use human ribosomes to produce the correct protein....
Key words
lipid, lipidlipids, lipidscomplex, complexnanoparticles, nanoparticlescolette, colettepivot, pivotspectroscopically, spectroscopicallybonnie, bonniedspc, dspcgiorgis, giorgisisaac, isaacquinn, quinnlnps, lnpsalden, aldenlnp
Rapid Analysis of Lipid Nanoparticle Components Using BioAccord™ LC-MS SystemGiorgis Isaac, Nilini Ranbaduge, Colette Quinn, Weibin Chen and Robert S. PlumbWaters Corporation, Milford, MAIntroduction▪ The recent success of mRNA vaccines in SARSCoV-2 clinical trials is in part due to thedevelopment...
Key words
lnp, lnplipid, lipidnanoparticle, nanoparticlebioaccord, bioaccorddspc, dspcmrna, mrnaspectroscopically, spectroscopicallybinary, binarydelivery, deliverycomponents, componentspegylated, pegylatedsilent, silentattack, attackanalysis, analysisspectra
Analysis of Lipid Nanoparticle Composition
2022|Agilent Technologies|Applications
Application NoteBiopharmaAnalysis of LipidNanoparticle CompositionAuthorSonja SchneiderAgilent Technologies, Inc.0DLin-MC3-DMADMG-PEG 2000DSPC×1024.754.504.254.003.753.503.253.002.752.502.252.001.751.501.251.000.750.50CholesterolResponse (LSU)Quaternary method development for highestresolution with evaporative light scattering detection0.5 1.0 1.5 2.0 2.5 3.0 3.5 4.0 4.5 5.0 5.5 6.0 6.5 7.0 7.5 8.0 8.5 9.0 9.5Retention time (min)AbstractLipid nanoparticles...
Key words
dspc, dspclipid, lipidcholesterol, cholesterollsu, lsulnp, lnpchannel, channelmeoh, meohcomponents, componentsfour, fouracn, acnquaternary, quaternaryresponse, responserna, rnaretention, retentionlnps
 

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Application NoteRapid Analysis of Lipid NanoparticleComponents Using BioAccord LC-MS SystemGiorgis Isaac, Nilini Ranbaduge, Bonnie A. Alden, Colette Quinn, Weibin Chen, Robert S. PlumbWaters CorporationAbstractThe recent success of mRNA vaccines for COVID-19 is in part due to the development of lipid...
Key words
lipid, lipidbioaccord, bioaccordlnp, lnpnanoparticle, nanoparticleunifi, unifilnps, lnpsclasses, classescompare, comparedeliver, deliverunknown, unknownimpurities, impuritiesfactorial, factorialthereof, thereoffunction, functionfractional
LIPID NANOPARTICLES—GET TO KNOW THEM ANALYTICALLYGiorgis Isaac; Nilini Ranbaduge; Bonnie Alden; Colette Quinn; Weibin ChenWaters Corporation, Milford, MA 01757INTRODUCTIONLipid Nanoparticles (LNPs)The recent success of mRNA vaccines is largely due to their abilityto use human ribosomes to produce the correct protein....
Key words
lipid, lipidlipids, lipidscomplex, complexnanoparticles, nanoparticlescolette, colettepivot, pivotspectroscopically, spectroscopicallybonnie, bonniedspc, dspcgiorgis, giorgisisaac, isaacquinn, quinnlnps, lnpsalden, aldenlnp
Rapid Analysis of Lipid Nanoparticle Components Using BioAccord™ LC-MS SystemGiorgis Isaac, Nilini Ranbaduge, Colette Quinn, Weibin Chen and Robert S. PlumbWaters Corporation, Milford, MAIntroduction▪ The recent success of mRNA vaccines in SARSCoV-2 clinical trials is in part due to thedevelopment...
Key words
lnp, lnplipid, lipidnanoparticle, nanoparticlebioaccord, bioaccorddspc, dspcmrna, mrnaspectroscopically, spectroscopicallybinary, binarydelivery, deliverycomponents, componentspegylated, pegylatedsilent, silentattack, attackanalysis, analysisspectra
Analysis of Lipid Nanoparticle Composition
2022|Agilent Technologies|Applications
Application NoteBiopharmaAnalysis of LipidNanoparticle CompositionAuthorSonja SchneiderAgilent Technologies, Inc.0DLin-MC3-DMADMG-PEG 2000DSPC×1024.754.504.254.003.753.503.253.002.752.502.252.001.751.501.251.000.750.50CholesterolResponse (LSU)Quaternary method development for highestresolution with evaporative light scattering detection0.5 1.0 1.5 2.0 2.5 3.0 3.5 4.0 4.5 5.0 5.5 6.0 6.5 7.0 7.5 8.0 8.5 9.0 9.5Retention time (min)AbstractLipid nanoparticles...
Key words
dspc, dspclipid, lipidcholesterol, cholesterollsu, lsulnp, lnpchannel, channelmeoh, meohcomponents, componentsfour, fouracn, acnquaternary, quaternaryresponse, responserna, rnaretention, retentionlnps
 

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