Lipid Nanoparticle Compositional Analysis Using Charged Surface Hybrid Phenyl-Hexyl Separation With Evaporative Light Scattering DetectionApplications | 2021 | Waters InstrumentationHPLCIndustriesLipidomicsManufacturerWatersKey wordslipid, hexyl, phenyl, evaporative, hydrophobicity, scattering, stationary, help, nanoparticle, nanoparticles, acquity, csh, light, garnering, onpattro, uplc, lipids, exploding, charged, lower, proven, sharpness, extremely, pharmacology, phases, surface, els, chelating, even, referenced, elution, detection, phase, cationic, test, symmetrical, compositional, explored, dealing, waters, need, efforts, symmetry, analytes, photodiode, conditions, ligand, thereby, assisted, effectiveness
Rapid Analysis of Lipid Nanoparticle Components Using BioAccord LC-MS System
Application NoteRapid Analysis of Lipid NanoparticleComponents Using BioAccord LC-MS SystemGiorgis Isaac, Nilini Ranbaduge, Bonnie A. Alden, Colette Quinn, Weibin Chen, Robert S. PlumbWaters CorporationAbstractThe recent success of mRNA vaccines for COVID-19 is in part due to the development of lipid...
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LIPID NANOPARTICLES — GET TO KNOW THEM ANALYTICALLY
LIPID NANOPARTICLES—GET TO KNOW THEM ANALYTICALLYGiorgis Isaac; Nilini Ranbaduge; Bonnie Alden; Colette Quinn; Weibin ChenWaters Corporation, Milford, MA 01757INTRODUCTIONLipid Nanoparticles (LNPs)The recent success of mRNA vaccines is largely due to their abilityto use human ribosomes to produce the correct protein....
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ASMS 2021: Rapid Analysis of Lipid Nanoparticle Components Using BioAccord™ LC-MS System
Rapid Analysis of Lipid Nanoparticle Components Using BioAccord™ LC-MS SystemGiorgis Isaac, Nilini Ranbaduge, Colette Quinn, Weibin Chen and Robert S. PlumbWaters Corporation, Milford, MAIntroduction▪ The recent success of mRNA vaccines in SARSCoV-2 clinical trials is in part due to thedevelopment...
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Analysis of Lipid Nanoparticle Composition
Application NoteBiopharmaAnalysis of LipidNanoparticle CompositionAuthorSonja SchneiderAgilent Technologies, Inc.0DLin-MC3-DMADMG-PEG 2000DSPC×1024.754.504.254.003.753.503.253.002.752.502.252.001.751.501.251.000.750.50CholesterolResponse (LSU)Quaternary method development for highestresolution with evaporative light scattering detection0.5 1.0 1.5 2.0 2.5 3.0 3.5 4.0 4.5 5.0 5.5 6.0 6.5 7.0 7.5 8.0 8.5 9.0 9.5Retention time (min)AbstractLipid nanoparticles...
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