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Lipid Nanoparticle Compositional Analysis Using Charged Surface Hybrid Phenyl-Hexyl Separation With Evaporative Light Scattering Detection

 

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Analysis of Lipid Nanoparticle Composition
2022|Agilent Technologies|Applications
Application Note Biopharma Analysis of Lipid Nanoparticle Composition Author Sonja Schneider Agilent Technologies, Inc. 0 DLin-MC3-DMA DMG-PEG 2000 DSPC ×102 4.75 4.50 4.25 4.00 3.75 3.50 3.25 3.00 2.75 2.50 2.25 2.00 1.75 1.50 1.25 1.00 0.75 0.50 Cholesterol Response…
Key words
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Application Note Lipid Nanoparticle Analysis: Leveraging MS to Reduce Risk Duanduan Han, Kellen DeLaney, Bonnie A. Alden, Robert E. Birdsall, Ying Qing Yu Waters Corporation Abstract Lipid nanoparticles (LNPs) represent an elegant solution in the delivery of gene-based therapeutics that…
Key words
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Application Note Characterizing and Monitoring Impurities in Lipid Nanoparticle Components Using the BioAccord™ LC-MS System with waters_connect™ Software Kellen DeLaney, Duanduan Han, Robert E. Birdsall, Ying Qing Yu Waters Corporation Abstract Lipid nanoparticles (LNP) have been used with high efficacy…
Key words
bioaccord, bioaccordlipid, lipidnanoparticle, nanoparticlecharacterizing, characterizingimpurities, impuritiesmonitoring, monitoringcomponents, componentssystem, systemlnp, lnpusing, usingfragment, fragmentvehicles, vehiclesmatching, matchingimpurity, impuritynanoparticles
Lipid Nanoparticle Impurity Monitoring Using Single Quadrupole Mass Detection for Regulated Environments Authors: Duanduan Han, Kellen DeLaney, Robert E. Birdsall, Ying Qing Yu Affiliation: Waters Corporation, Milford, MA Results Introduction Lipid Nanoparticles UV 3 AU 2 Cholesterol • Important for…
Key words
elsd, elsddspc, dspcdesaturation, desaturationsaturation, saturationoxidation, oxidationdata, datalipid, lipidimpurity, impuritycompositional, compositionalcholesterol, cholesterolqda, qdamass, massassignment, assignmentcomplementary, complementaryvolatile
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