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Determination of Fatty Acids Composition in Polysorbate 20 Pharmaceutical Raw Material Using HPLC with MS Detection

 

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QUALITY ASSESSMENT OF POLYSORBATES 80 AND 20 PHARMACEUTICAL RAW MATERIALS BY MEASURING FATTY ACIDS COMPOSITION USING HPLC WITH MASS DETECTION Authors: Margaret Maziarz, Paul Rainville, Isabelle VuTrieu, Andrew Leightner Affiliations: Waters Corporation, Milford, MA The U.S. Pharmacopoeia specifies a gas…
Key words
apex, apexoleic, oleicpalmitic, palmiticfatty, fattystearic, steariclinoleic, linoleicacid, acidmyristic, myristicpalmitoleic, palmitoleicminutes, minutesintensity, intensityvaccenic, vaccenicpolysorbates, polysorbateselaidic, elaidicacids
Quality assessment of Polysorbates 80 and 20 Pharmaceutical Raw Materials by Measuring Fatty Acids Composition using HPLC with Mass Detection M123008-52 Margaret Maziarz, Paul Rainville Waters Corporation, 34 Maple Street, Milford MA CONTACT INFORMATION: [email protected], [email protected] PURPOSE Polysorbates are non-ionic…
Key words
fatty, fattyoleic, oleicpalmitic, palmiticpolysorbates, polysorbatesacids, acidsstearic, stearicpalmitoleic, palmitoleicpolysorbate, polysorbatecomposition, compositionmyristic, myristicminutes, minuteslinoleic, linoleicexcipients, excipientshydrolyzed, hydrolyzedhplc
Repeatability and Quantitation in a Method Using the Alliance HPLC System with the 2998 Photodiode Array Detector and the ACQUITY QDa Detector Aparna Chavali, Thomas E. Wheat, Patricia McConville Waters Corporation, Milford, MA, USA A P P L I C…
Key words
ism, ismalliance, allianceirbesartan, irbesartanqda, qdapda, pdaapi, apiacquity, acquityarea, arearsd, rsdrca, rcahplc, hplcdetector, detectorsolvent, solventtee, teesplitter
Application Note Quantitative Analysis of Polysorbate 20/80 in Protein-Based Biopharmaceuticals Using A One-Pot RPLC-MS Based Platform Method Robert E. Birdsall, David Dao, Brooke M. Koshel, Ying Qing Yu, Aude Smeets, Michel Gerodez, Xavier Taillieu Waters Corporation, GlaxoSmithKline Abstract A high…
Key words
polysorbate, polysorbatemethyl, methylhydrolysis, hydrolysisqda, qdaacquity, acquitylaurate, lauratefatty, fattybased, basedoleate, oleatesir, sirdetection, detectionneighboring, neighboringmyristate, myristatemethod, methodpalmitate
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