ASMS 2021: Utilization of Novel Low Adsorption Chromatographic Surface Technology for Improved Bioanalytical Quantitation of OligonucleotidesPosters | 2021 | WatersInstrumentation
HPLC, LC/MS, LC/MS/MS, LC/QQQ
Industries
Proteomics
Manufacturer
Waters
Key words

 

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DEVELOPMENT OF A BIOANALYTICAL SPE LC-MS/MS ASSAYFOR OLIGONUCLEOTIDESMary Lame, Kathryn Brennan, Michael Donegan, Thanai Paxton, and Ian EdwardsWaters Corporation, 34 Maple Street, Milford, MA , USAINTRODUCTIONRESULTSOver the past decade, there has been a dramatic increase inresearch toward oligonucleotides therapies (ONTs)....
Key words
ost, ostmassprep, masspreparea, areaspe, speoasis, oasisoligonucleotide, oligonucleotiderecovery, recoverytea, teawax, waxtime, timeoligonucleotides, oligonucleotideshlb, hlbbioanalytical, bioanalyticaltic, ticwaters
Application NoteImproved Oligonucleotide SPE-LC-MSAnalysis Using MaxPeak High PerformanceTechnologyKathryn Brennan, Mary Trudeau Lame, Michael Donegan, Paul D. RainvilleWaters Corporation AbstractThe demand for highly selective and sensitive LC-MS bioanalytical assays in support of researchand development of next-generation oligonucleotide therapies has greatly increased. The...
Key words
oligonucleotide, oligonucleotideacquity, acquityspe, spexevo, xevomaxpeak, maxpeakpremier, premieryielded, yieldeduplc, uplcbioanalytical, bioanalyticaltargetlynx, targetlynxtea, teaassays, assaysquantification, quantificationrecovery, recoverydemand
Application NoteUtilization of the ACQUITY PREMIERSystem and Column for ImprovedOligonucleotide BioanalyticalChromatographic PerformanceKathryn Brennan, Mary Trudeau, Paul D. RainvilleWaters CorporationThis is an Application Brief and does not contain a detailed Experimental section. AbstractLC-MS/MS bioanalytical quantification of oligonucleotide therapeutics requires sensitive and robustanalytical...
Key words
premier, premieracquity, acquitysystem, systemoligonucleotide, oligonucleotidebioanalytical, bioanalyticaloligodeoxythymidine, oligodeoxythymidinecolumn, columnuplc, uplcperformance, performancelengthy, lengthyincorporation, incorporationcompared, comparedtherapeutics, therapeuticsutilization, utilizationchromatographic
Application NoteImproving Recovery and Quantitation ofOligonucleotide Impurities Using ACQUITYPREMIER with MaxPeak HPS TechnologyBrooke M. Koshel, Robert E. Birdsall, Ying Qing YuWaters Corporation AbstractIon-pair reversed-phase chromatography is a commonly used technique for the separation of syntheticoligonucleotide impurities. Analysis of oligonucleotides is notoriously...
Key words
premier, premieroligonucleotide, oligonucleotideacquity, acquitymaxpeak, maxpeakhps, hpsoligonucleotides, oligonucleotidessystem, systemtechnology, technologyimpurities, impuritiespassivation, passivationconventional, conventionalsurfaces, surfacesminutes, minutesmetal, metalrecovery

ASMS 2021: Utilization of Novel Low Adsorption Chromatographic Surface Technology for Improved Bioanalytical Quantitation of OligonucleotidesPosters | 2021 | WatersInstrumentation
HPLC, LC/MS, LC/MS/MS, LC/QQQ
Industries
Proteomics
Manufacturer
Waters
Key words

 

Similar PDF

Toggle
DEVELOPMENT OF A BIOANALYTICAL SPE LC-MS/MS ASSAYFOR OLIGONUCLEOTIDESMary Lame, Kathryn Brennan, Michael Donegan, Thanai Paxton, and Ian EdwardsWaters Corporation, 34 Maple Street, Milford, MA , USAINTRODUCTIONRESULTSOver the past decade, there has been a dramatic increase inresearch toward oligonucleotides therapies (ONTs)....
Key words
ost, ostmassprep, masspreparea, areaspe, speoasis, oasisoligonucleotide, oligonucleotiderecovery, recoverytea, teawax, waxtime, timeoligonucleotides, oligonucleotideshlb, hlbbioanalytical, bioanalyticaltic, ticwaters
Application NoteImproved Oligonucleotide SPE-LC-MSAnalysis Using MaxPeak High PerformanceTechnologyKathryn Brennan, Mary Trudeau Lame, Michael Donegan, Paul D. RainvilleWaters Corporation AbstractThe demand for highly selective and sensitive LC-MS bioanalytical assays in support of researchand development of next-generation oligonucleotide therapies has greatly increased. The...
Key words
oligonucleotide, oligonucleotideacquity, acquityspe, spexevo, xevomaxpeak, maxpeakpremier, premieryielded, yieldeduplc, uplcbioanalytical, bioanalyticaltargetlynx, targetlynxtea, teaassays, assaysquantification, quantificationrecovery, recoverydemand
Application NoteUtilization of the ACQUITY PREMIERSystem and Column for ImprovedOligonucleotide BioanalyticalChromatographic PerformanceKathryn Brennan, Mary Trudeau, Paul D. RainvilleWaters CorporationThis is an Application Brief and does not contain a detailed Experimental section. AbstractLC-MS/MS bioanalytical quantification of oligonucleotide therapeutics requires sensitive and robustanalytical...
Key words
premier, premieracquity, acquitysystem, systemoligonucleotide, oligonucleotidebioanalytical, bioanalyticaloligodeoxythymidine, oligodeoxythymidinecolumn, columnuplc, uplcperformance, performancelengthy, lengthyincorporation, incorporationcompared, comparedtherapeutics, therapeuticsutilization, utilizationchromatographic
Application NoteImproving Recovery and Quantitation ofOligonucleotide Impurities Using ACQUITYPREMIER with MaxPeak HPS TechnologyBrooke M. Koshel, Robert E. Birdsall, Ying Qing YuWaters Corporation AbstractIon-pair reversed-phase chromatography is a commonly used technique for the separation of syntheticoligonucleotide impurities. Analysis of oligonucleotides is notoriously...
Key words
premier, premieroligonucleotide, oligonucleotideacquity, acquitymaxpeak, maxpeakhps, hpsoligonucleotides, oligonucleotidessystem, systemtechnology, technologyimpurities, impuritiespassivation, passivationconventional, conventionalsurfaces, surfacesminutes, minutesmetal, metalrecovery
 

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