ASMS 2021: Utilization of Novel Low Adsorption Chromatographic Surface Technology for Improved Bioanalytical Quantitation of Oligonucleotides | LabRulez LCMS
 

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Application NoteImproved Oligonucleotide SPE-LC-MSAnalysis Using MaxPeak High PerformanceTechnologyKathryn Brennan, Mary Trudeau Lame, Michael Donegan, Paul D. RainvilleWaters Corporation AbstractThe demand for highly selective and sensitive LC-MS bioanalytical assays in support of researchand development of next-generation oligonucleotide therapies has greatly increased. The...
Key words
oligonucleotide, oligonucleotideacquity, acquityspe, spexevo, xevomaxpeak, maxpeakuplc, uplctargetlynx, targetlynxyielded, yieldedbioanalytical, bioanalyticalpremier, premiertea, teaassays, assaysquantification, quantificationdemand, demandrecovery
Application NoteUtilization of the ACQUITY PREMIERSystem and Column for ImprovedOligonucleotide BioanalyticalChromatographic PerformanceKathryn Brennan, Mary Trudeau, Paul D. RainvilleWaters CorporationThis is an Application Brief and does not contain a detailed Experimental section. AbstractLC-MS/MS bioanalytical quantification of oligonucleotide therapeutics requires sensitive and robustanalytical...
Key words
premier, premieracquity, acquitysystem, systemoligonucleotide, oligonucleotidebioanalytical, bioanalyticalcolumn, columnoligodeoxythymidine, oligodeoxythymidineperformance, performanceuplc, uplclengthy, lengthyincorporation, incorporationcompared, comparedtherapeutics, therapeuticsutilization, utilizationchromatographic
Application NoteSensitive LC-MS/MS BioanalyticalQuantitation of Antisense OligonucleotidesSuma Veeramachineni, Mark D. WronaWaters CorporationAbstractThis application demonstrates the quantitative and qualitative capabilities of the Waters™ Xevo™ TQ AbsoluteTandem Quadrupole Mass Spectrometer (MS/MS) and its suitability for oligonucleotide bioanalysis in humanplasma.Sensitive LC-MS/MS Bioanalytical Quantitation...
Key words
antisense, antisenseoligonucleotides, oligonucleotidesbioanalytical, bioanalyticalsensitive, sensitivequantitation, quantitationpremier, premiertandem, tandemacquity, acquityabsolute, absolutewaters, watershps, hpsmaxpeak, maxpeakoligonucleotide, oligonucleotidehuman, humansurfaces
Improving LC-MS/MS Bioanalytical Quantitation of Oligonucleotides using New High PerformanceTandem Quadrupole Mass SpectrometerSuma Veeramachineni1; Suraj Dhungana1; Ying-Qing Yu1; Mark Wrona1; 1Waters Corporation, Milford, MAIntroductionResultsImprovingLC-MS/MSbioanalyticalperformanceespecially for ESI negative analytes has been of highinterest especially for the challenging analysis of ONTs(oligonucleotide therapeutics)...
Key words
oligonucleotide, oligonucleotideaccuracy, accuracyoligonucleotides, oligonucleotidesosts, ostsperformance, performanceantisense, antisensequantitation, quantitationbioanalytical, bioanalyticallloq, lloqconc, concstd, stdpolythymidine, polythymidinepremier, premieronts, ontswaters
 

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Application NoteImproved Oligonucleotide SPE-LC-MSAnalysis Using MaxPeak High PerformanceTechnologyKathryn Brennan, Mary Trudeau Lame, Michael Donegan, Paul D. RainvilleWaters Corporation AbstractThe demand for highly selective and sensitive LC-MS bioanalytical assays in support of researchand development of next-generation oligonucleotide therapies has greatly increased. The...
Key words
oligonucleotide, oligonucleotideacquity, acquityspe, spexevo, xevomaxpeak, maxpeakuplc, uplctargetlynx, targetlynxyielded, yieldedbioanalytical, bioanalyticalpremier, premiertea, teaassays, assaysquantification, quantificationdemand, demandrecovery
Application NoteUtilization of the ACQUITY PREMIERSystem and Column for ImprovedOligonucleotide BioanalyticalChromatographic PerformanceKathryn Brennan, Mary Trudeau, Paul D. RainvilleWaters CorporationThis is an Application Brief and does not contain a detailed Experimental section. AbstractLC-MS/MS bioanalytical quantification of oligonucleotide therapeutics requires sensitive and robustanalytical...
Key words
premier, premieracquity, acquitysystem, systemoligonucleotide, oligonucleotidebioanalytical, bioanalyticalcolumn, columnoligodeoxythymidine, oligodeoxythymidineperformance, performanceuplc, uplclengthy, lengthyincorporation, incorporationcompared, comparedtherapeutics, therapeuticsutilization, utilizationchromatographic
Application NoteSensitive LC-MS/MS BioanalyticalQuantitation of Antisense OligonucleotidesSuma Veeramachineni, Mark D. WronaWaters CorporationAbstractThis application demonstrates the quantitative and qualitative capabilities of the Waters™ Xevo™ TQ AbsoluteTandem Quadrupole Mass Spectrometer (MS/MS) and its suitability for oligonucleotide bioanalysis in humanplasma.Sensitive LC-MS/MS Bioanalytical Quantitation...
Key words
antisense, antisenseoligonucleotides, oligonucleotidesbioanalytical, bioanalyticalsensitive, sensitivequantitation, quantitationpremier, premiertandem, tandemacquity, acquityabsolute, absolutewaters, watershps, hpsmaxpeak, maxpeakoligonucleotide, oligonucleotidehuman, humansurfaces
Improving LC-MS/MS Bioanalytical Quantitation of Oligonucleotides using New High PerformanceTandem Quadrupole Mass SpectrometerSuma Veeramachineni1; Suraj Dhungana1; Ying-Qing Yu1; Mark Wrona1; 1Waters Corporation, Milford, MAIntroductionResultsImprovingLC-MS/MSbioanalyticalperformanceespecially for ESI negative analytes has been of highinterest especially for the challenging analysis of ONTs(oligonucleotide therapeutics)...
Key words
oligonucleotide, oligonucleotideaccuracy, accuracyoligonucleotides, oligonucleotidesosts, ostsperformance, performanceantisense, antisensequantitation, quantitationbioanalytical, bioanalyticallloq, lloqconc, concstd, stdpolythymidine, polythymidinepremier, premieronts, ontswaters
 

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