ASMS 2021: Utilization of Novel Low Adsorption Chromatographic Surface Technology for Improved Bioanalytical Quantitation of OligonucleotidesPosters | 2021 | Waters InstrumentationHPLC, LC/MS, LC/MS/MS, LC/QQQIndustriesProteomics ManufacturerWatersKey wordsuplc, acquity, premier, oligonucleotide, system, lle, bioanalytical, rsds, acuity, syschk, uplci, std, onts, gem, hst, phosphorothioated, column, antisense, plasma, conventional, disrupted, spe, curve, recovery, response, ensured, oligonucleotides, facilitated, utilization, extraction, neat, binding, developing, adsorption, low, conditioning, using, effectively, equilibration, load, elute, plate, treatment, novel, mixed, wash, surface, fully, blank, robust
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Improved Oligonucleotide SPE-LC-MS Analysis Using MaxPeak High Performance Technology
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Utilization of the ACQUITY PREMIER System and Column for Improved Oligonucleotide Bioanalytical Chromatographic Performance
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Application NoteSensitive LC-MS/MS BioanalyticalQuantitation of Antisense OligonucleotidesSuma Veeramachineni, Mark D. WronaWaters CorporationAbstractThis application demonstrates the quantitative and qualitative capabilities of the Waters™ Xevo™ TQ AbsoluteTandem Quadrupole Mass Spectrometer (MS/MS) and its suitability for oligonucleotide bioanalysis in humanplasma.Sensitive LC-MS/MS Bioanalytical Quantitation...
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ASMS: ©2022 Waters Corporation Download scientific posters at waters.com/posters Improving LC-MS/MS Bioanalytical Quantitation of Oligonucleotides using New High Performance Tandem Quadrupole Mass Spectrometer
2022|Waters|Posters
Improving LC-MS/MS Bioanalytical Quantitation of Oligonucleotides using New High PerformanceTandem Quadrupole Mass SpectrometerSuma Veeramachineni1; Suraj Dhungana1; Ying-Qing Yu1; Mark Wrona1; 1Waters Corporation, Milford, MAIntroductionResultsImprovingLC-MS/MSbioanalyticalperformanceespecially for ESI negative analytes has been of highinterest especially for the challenging analysis of ONTs(oligonucleotide therapeutics)...
Key words
oligonucleotide, oligonucleotideaccuracy, accuracyoligonucleotides, oligonucleotidesosts, ostsperformance, performanceantisense, antisensequantitation, quantitationbioanalytical, bioanalyticallloq, lloqconc, concstd, stdpolythymidine, polythymidinepremier, premieronts, ontswaters