ASMS 2021: Utilization of Novel Low Adsorption Chromatographic Surface Technology for Improved Bioanalytical Quantitation of OligonucleotidesPosters | 2021 | Waters InstrumentationHPLC, LC/MS, LC/MS/MS, LC/QQQIndustriesProteomics ManufacturerWatersKey wordsuplc, acquity, premier, oligonucleotide, system, lle, bioanalytical, rsds, acuity, syschk, uplci, std, onts, gem, hst, phosphorothioated, column, antisense, plasma, conventional, disrupted, spe, curve, recovery, response, ensured, oligonucleotides, facilitated, utilization, extraction, neat, binding, developing, adsorption, low, conditioning, using, effectively, equilibration, load, elute, plate, treatment, novel, mixed, wash, surface, fully, blank, robust
Improved Oligonucleotide SPE-LC-MS Analysis Using MaxPeak High Performance Technology
Application NoteImproved Oligonucleotide SPE-LC-MSAnalysis Using MaxPeak High PerformanceTechnologyKathryn Brennan, Mary Trudeau Lame, Michael Donegan, Paul D. RainvilleWaters CorporationAbstractThe demand for highly selective and sensitive LC-MS bioanalytical assays in support of researchand development of next-generation oligonucleotide therapies has greatly increased. The...
oligonucleotide, oligonucleotideacquity, acquityspe, spexevo, xevomaxpeak, maxpeakuplc, uplctargetlynx, targetlynxyielded, yieldedbioanalytical, bioanalyticalpremier, premiertea, teaassays, assaysquantification, quantificationdemand, demandrecovery
Utilization of the ACQUITY PREMIER System and Column for Improved Oligonucleotide Bioanalytical Chromatographic Performance
Application NoteUtilization of the ACQUITY PREMIERSystem and Column for ImprovedOligonucleotide BioanalyticalChromatographic PerformanceKathryn Brennan, Mary Trudeau, Paul D. RainvilleWaters CorporationThis is an Application Brief and does not contain a detailed Experimental section.AbstractLC-MS/MS bioanalytical quantification of oligonucleotide therapeutics requires sensitive and robustanalytical...
premier, premieracquity, acquitysystem, systemoligonucleotide, oligonucleotidebioanalytical, bioanalyticalcolumn, columnoligodeoxythymidine, oligodeoxythymidineperformance, performanceuplc, uplclengthy, lengthyincorporation, incorporationcompared, comparedtherapeutics, therapeuticsutilization, utilizationchromatographic
Sensitive LC-MS/MS Bioanalytical Quantitation of Antisense Oligonucleotides
Application NoteSensitive LC-MS/MS BioanalyticalQuantitation of Antisense OligonucleotidesSuma Veeramachineni, Mark D. WronaWaters CorporationAbstractThis application demonstrates the quantitative and qualitative capabilities of the Waters™ Xevo™ TQ AbsoluteTandem Quadrupole Mass Spectrometer (MS/MS) and its suitability for oligonucleotide bioanalysis in humanplasma.Sensitive LC-MS/MS Bioanalytical Quantitation...
antisense, antisenseoligonucleotides, oligonucleotidesbioanalytical, bioanalyticalsensitive, sensitivequantitation, quantitationpremier, premiertandem, tandemacquity, acquityabsolute, absolutewaters, watershps, hpsmaxpeak, maxpeakoligonucleotide, oligonucleotidehuman, humansurfaces
ASMS: ©2022 Waters Corporation Download scientific posters at waters.com/posters Improving LC-MS/MS Bioanalytical Quantitation of Oligonucleotides using New High Performance Tandem Quadrupole Mass Spectrometer
Improving LC-MS/MS Bioanalytical Quantitation of Oligonucleotides using New High PerformanceTandem Quadrupole Mass SpectrometerSuma Veeramachineni1; Suraj Dhungana1; Ying-Qing Yu1; Mark Wrona1; 1Waters Corporation, Milford, MAIntroductionResultsImprovingLC-MS/MSbioanalyticalperformanceespecially for ESI negative analytes has been of highinterest especially for the challenging analysis of ONTs(oligonucleotide therapeutics)...
oligonucleotide, oligonucleotideaccuracy, accuracyoligonucleotides, oligonucleotidesosts, ostsperformance, performanceantisense, antisensequantitation, quantitationbioanalytical, bioanalyticallloq, lloqconc, concstd, stdpolythymidine, polythymidinepremier, premieronts, ontswaters