ASMS 2021: Utilization of Novel Low Adsorption Chromatographic Surface Technology for Improved Bioanalytical Quantitation of Oligonucleotides | LabRulez LCMS_EN
 

Similar PDF

Toggle
Application NoteImproved Oligonucleotide SPE-LC-MSAnalysis Using MaxPeak High PerformanceTechnologyKathryn Brennan, Mary Trudeau Lame, Michael Donegan, Paul D. RainvilleWaters Corporation AbstractThe demand for highly selective and sensitive LC-MS bioanalytical assays in support of researchand development of next-generation oligonucleotide therapies has greatly increased. The...
Key words
oligonucleotide, oligonucleotideacquity, acquityspe, spexevo, xevomaxpeak, maxpeakuplc, uplcyielded, yieldedpremier, premiertargetlynx, targetlynxbioanalytical, bioanalyticaltea, teaassays, assaysquantification, quantificationdemand, demandrecovery
Application NoteUtilization of the ACQUITY PREMIERSystem and Column for ImprovedOligonucleotide BioanalyticalChromatographic PerformanceKathryn Brennan, Mary Trudeau, Paul D. RainvilleWaters CorporationThis is an Application Brief and does not contain a detailed Experimental section. AbstractLC-MS/MS bioanalytical quantification of oligonucleotide therapeutics requires sensitive and robustanalytical...
Key words
premier, premieracquity, acquitysystem, systemoligonucleotide, oligonucleotidebioanalytical, bioanalyticaloligodeoxythymidine, oligodeoxythymidinecolumn, columnuplc, uplcperformance, performancelengthy, lengthyincorporation, incorporationcompared, comparedtherapeutics, therapeuticsutilization, utilizationchromatographic
Application NoteSensitive LC-MS/MS BioanalyticalQuantitation of Antisense OligonucleotidesSuma Veeramachineni, Mark D. WronaWaters CorporationAbstractThis application demonstrates the quantitative and qualitative capabilities of the Waters™ Xevo™ TQ AbsoluteTandem Quadrupole Mass Spectrometer (MS/MS) and its suitability for oligonucleotide bioanalysis in humanplasma.Sensitive LC-MS/MS Bioanalytical Quantitation...
Key words
antisense, antisenseoligonucleotides, oligonucleotidesbioanalytical, bioanalyticalsensitive, sensitivequantitation, quantitationpremier, premiertandem, tandemacquity, acquityabsolute, absolutewaters, watershps, hpsoligonucleotide, oligonucleotidemaxpeak, maxpeakhuman, humansurfaces
Improving LC-MS/MS Bioanalytical Quantitation of Oligonucleotides using New High PerformanceTandem Quadrupole Mass SpectrometerSuma Veeramachineni1; Suraj Dhungana1; Ying-Qing Yu1; Mark Wrona1; 1Waters Corporation, Milford, MAIntroductionResultsImprovingLC-MS/MSbioanalyticalperformanceespecially for ESI negative analytes has been of highinterest especially for the challenging analysis of ONTs(oligonucleotide therapeutics)...
Key words
oligonucleotide, oligonucleotideoligonucleotides, oligonucleotidesaccuracy, accuracyosts, ostsperformance, performanceantisense, antisensequantitation, quantitationbioanalytical, bioanalyticallloq, lloqpolythymidine, polythymidineconc, concpremier, premierstd, stdonts, ontswaters
 

Similar PDF

Toggle
Application NoteImproved Oligonucleotide SPE-LC-MSAnalysis Using MaxPeak High PerformanceTechnologyKathryn Brennan, Mary Trudeau Lame, Michael Donegan, Paul D. RainvilleWaters Corporation AbstractThe demand for highly selective and sensitive LC-MS bioanalytical assays in support of researchand development of next-generation oligonucleotide therapies has greatly increased. The...
Key words
oligonucleotide, oligonucleotideacquity, acquityspe, spexevo, xevomaxpeak, maxpeakuplc, uplcyielded, yieldedpremier, premiertargetlynx, targetlynxbioanalytical, bioanalyticaltea, teaassays, assaysquantification, quantificationdemand, demandrecovery
Application NoteUtilization of the ACQUITY PREMIERSystem and Column for ImprovedOligonucleotide BioanalyticalChromatographic PerformanceKathryn Brennan, Mary Trudeau, Paul D. RainvilleWaters CorporationThis is an Application Brief and does not contain a detailed Experimental section. AbstractLC-MS/MS bioanalytical quantification of oligonucleotide therapeutics requires sensitive and robustanalytical...
Key words
premier, premieracquity, acquitysystem, systemoligonucleotide, oligonucleotidebioanalytical, bioanalyticaloligodeoxythymidine, oligodeoxythymidinecolumn, columnuplc, uplcperformance, performancelengthy, lengthyincorporation, incorporationcompared, comparedtherapeutics, therapeuticsutilization, utilizationchromatographic
Application NoteSensitive LC-MS/MS BioanalyticalQuantitation of Antisense OligonucleotidesSuma Veeramachineni, Mark D. WronaWaters CorporationAbstractThis application demonstrates the quantitative and qualitative capabilities of the Waters™ Xevo™ TQ AbsoluteTandem Quadrupole Mass Spectrometer (MS/MS) and its suitability for oligonucleotide bioanalysis in humanplasma.Sensitive LC-MS/MS Bioanalytical Quantitation...
Key words
antisense, antisenseoligonucleotides, oligonucleotidesbioanalytical, bioanalyticalsensitive, sensitivequantitation, quantitationpremier, premiertandem, tandemacquity, acquityabsolute, absolutewaters, watershps, hpsoligonucleotide, oligonucleotidemaxpeak, maxpeakhuman, humansurfaces
Improving LC-MS/MS Bioanalytical Quantitation of Oligonucleotides using New High PerformanceTandem Quadrupole Mass SpectrometerSuma Veeramachineni1; Suraj Dhungana1; Ying-Qing Yu1; Mark Wrona1; 1Waters Corporation, Milford, MAIntroductionResultsImprovingLC-MS/MSbioanalyticalperformanceespecially for ESI negative analytes has been of highinterest especially for the challenging analysis of ONTs(oligonucleotide therapeutics)...
Key words
oligonucleotide, oligonucleotideoligonucleotides, oligonucleotidesaccuracy, accuracyosts, ostsperformance, performanceantisense, antisensequantitation, quantitationbioanalytical, bioanalyticallloq, lloqpolythymidine, polythymidineconc, concpremier, premierstd, stdonts, ontswaters
 

Related content

Waters XEVO G3 QTof

Brochures and specifications
| 2022 | Waters
Instrumentation
LC/TOF, LC/HRMS, LC/MS, LC/MS/MS
Manufacturer
Waters
Industries
---

Normal phase liquid chromatography assay for vitamin K1 isomers

Applications
| 2022 | Thermo Fischer Scientific
Instrumentation
HPLC
Manufacturer
Thermo Fischer Scientific
Industries
Food & Agriculture

Agilent 6475 triple quadrupole LC/MS

Brochures and specifications
| 2022 | Agilent Technologies
Instrumentation
LC/MS, LC/MS/MS, LC/QQQ
Manufacturer
Agilent Technologies
Industries
---

Shimadzu Liquid Chromatograph Mass Spectrometer LCMS-2050

Brochures and specifications
| 2022 | Shimadzu
Instrumentation
LC/MS, LC/SQ
Manufacturer
Shimadzu
Industries
---

Overcoming the challenges of liquid chromatography method transfer: A CDMO perspective

Technical notes
| 2022 | Thermo Fischer Scientific
Instrumentation
HPLC
Manufacturer
Thermo Fischer Scientific
Industries
---
 

Related content

Waters XEVO G3 QTof

Brochures and specifications
| 2022 | Waters
Instrumentation
LC/TOF, LC/HRMS, LC/MS, LC/MS/MS
Manufacturer
Waters
Industries
---

Normal phase liquid chromatography assay for vitamin K1 isomers

Applications
| 2022 | Thermo Fischer Scientific
Instrumentation
HPLC
Manufacturer
Thermo Fischer Scientific
Industries
Food & Agriculture

Agilent 6475 triple quadrupole LC/MS

Brochures and specifications
| 2022 | Agilent Technologies
Instrumentation
LC/MS, LC/MS/MS, LC/QQQ
Manufacturer
Agilent Technologies
Industries
---

Shimadzu Liquid Chromatograph Mass Spectrometer LCMS-2050

Brochures and specifications
| 2022 | Shimadzu
Instrumentation
LC/MS, LC/SQ
Manufacturer
Shimadzu
Industries
---

Overcoming the challenges of liquid chromatography method transfer: A CDMO perspective

Technical notes
| 2022 | Thermo Fischer Scientific
Instrumentation
HPLC
Manufacturer
Thermo Fischer Scientific
Industries
---
Other projects
Follow us
More information
WebinarsAbout usContact usTerms of use

LabRulez s.r.o., all rights reserved.