ASMS 2021: Utilization of Novel Low Adsorption Chromatographic Surface Technology for Improved Bioanalytical Quantitation of OligonucleotidesPosters | 2021 | WatersInstrumentationHPLC, LC/MS, LC/MS/MS, LC/QQQIndustriesProteomics ManufacturerWatersKey wordsuplc, acquity, premier, oligonucleotide, system, lle, bioanalytical, acuity, onts, syschk, uplci, rsds, std, phosphorothioated, hst, gem, antisense, column, plasma, conventional, spe, disrupted, curve, ensured, recovery, oligonucleotides, response, facilitated, utilization, extraction, neat, binding, developing, low, conditioning, adsorption, using, effectively, load, equilibration, treatment, plate, elute, mixed, wash, novel, fully, surface, blank, robust
DEVELOPMENT OF A BIOANALYTICAL SPE LC-MS/MS ASSAY FOR OLIGONUCLEOTIDES
DEVELOPMENT OF A BIOANALYTICAL SPE LC-MS/MS ASSAYFOR OLIGONUCLEOTIDESMary Lame, Kathryn Brennan, Michael Donegan, Thanai Paxton, and Ian EdwardsWaters Corporation, 34 Maple Street, Milford, MA , USAINTRODUCTIONRESULTSOver the past decade, there has been a dramatic increase inresearch toward oligonucleotides therapies (ONTs)....
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Improved Oligonucleotide SPE-LC-MS Analysis Using MaxPeak High Performance Technology
Application NoteImproved Oligonucleotide SPE-LC-MSAnalysis Using MaxPeak High PerformanceTechnologyKathryn Brennan, Mary Trudeau Lame, Michael Donegan, Paul D. RainvilleWaters CorporationAbstractThe demand for highly selective and sensitive LC-MS bioanalytical assays in support of researchand development of next-generation oligonucleotide therapies has greatly increased. The...
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Utilization of the ACQUITY PREMIER System and Column for Improved Oligonucleotide Bioanalytical Chromatographic Performance
Application NoteUtilization of the ACQUITY PREMIERSystem and Column for ImprovedOligonucleotide BioanalyticalChromatographic PerformanceKathryn Brennan, Mary Trudeau, Paul D. RainvilleWaters CorporationThis is an Application Brief and does not contain a detailed Experimental section.AbstractLC-MS/MS bioanalytical quantification of oligonucleotide therapeutics requires sensitive and robustanalytical...
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Improving Recovery and Quantitation of Oligonucleotide Impurities Using ACQUITY PREMIER with MaxPeak HPS Technology
Application NoteImproving Recovery and Quantitation ofOligonucleotide Impurities Using ACQUITYPREMIER with MaxPeak HPS TechnologyBrooke M. Koshel, Robert E. Birdsall, Ying Qing YuWaters CorporationAbstractIon-pair reversed-phase chromatography is a commonly used technique for the separation of syntheticoligonucleotide impurities. Analysis of oligonucleotides is notoriously...
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