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Analysis of Cysteine-Linked Antibody Drug Conjugates
2017|Agilent Technologies|Applications
Analysis of Cysteine-LinkedAntibody Drug ConjugatesUsing Hydrophobic Interaction Chromatography on theAgilent 1260 Infinity II Bio-inert LCApplication NoteBiologics and BiosimilarsAuthorAbstractSonja SchneiderHydrophobic interaction chromatography (HIC) is frequently used for theAgilent Technologies, Inc.determination of drug-to-antibody ratio (DAR) of cysteine-linked antibody drugWaldbronn, Germanyconjugates (ADCs). The...
Key words
brentuximab, brentuximabvedotin, vedotindar, darhic, hicdrug, drugantibody, antibodyhydrophobic, hydrophobicmmae, mmaeadcs, adcsadc, adcinteraction, interactiontige, tigemab, mablinked, linkedcleavable
[ TECHNOLOGY BRIEF ]Analysis of Antibody Drug Conjugates (ADCs) by Native Mass Spectrometryon the BioAccord SystemHenry Shion, Ying Qing Yu, and Weibin ChenWaters Corporation, Milford, MA, USADrug-to-Antibody Ratio (DAR) determination of Lys andCys conjugated ADCs was accomplished using analyticalscale size...
Key words
bioaccord, bioaccordconjugated, conjugatedadc, adcdar, daradcs, adcsnative, nativedrug, drugantibody, antibodysystem, systemcovalent, covalentbrief, briefsec, secconjugates, conjugatescysteine, cysteinelysine
Analytical Scale Native SEC-MS for Antibody-Drug Conjugates(ADCs) CharacterizationHenry Shion, Ying Qing Yu, and Weibin ChenWaters Corporation, Milford, MA, USAAPPLICATION BENEFITS■■■■■■An improved native mass spectrometrywith analytical scale Size ExclusionChromatography (SEC) method isdeveloped for characterization ofcysteine-conjugated and lysineconjugated ADCs.This improved method offers...
Key words
adcs, adcsnative, nativesec, secdar, dardrug, drugantibody, antibodyhic, hicscale, scaleconjugated, conjugatedcharacterization, characterizationconjugates, conjugatesprotein, proteinuplc, uplcvion, vionconjugation
Automating the Determination of Drug-to-Antibody Ratio (DAR)of Antibody Drug Conjugates (ADCs) Based on Separationby Hydrophobic Interaction Chromatography (HIC)Robert Birdsall, Eoin Cosgrave, Henry Shion, and Weibin ChenWaters Corporation, Milford, MA, USAA P P L I C AT I O N B...
Key words
dar, darantibody, antibodyadcs, adcsdrug, drugconjugates, conjugatesautomating, automatingcalculations, calculationscqas, cqasratio, ratiodetermination, determinationhic, hicconjugated, conjugateduplc, uplcacquity, acquitycysteine
 

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Analysis of Cysteine-Linked Antibody Drug Conjugates
2017|Agilent Technologies|Applications
Analysis of Cysteine-LinkedAntibody Drug ConjugatesUsing Hydrophobic Interaction Chromatography on theAgilent 1260 Infinity II Bio-inert LCApplication NoteBiologics and BiosimilarsAuthorAbstractSonja SchneiderHydrophobic interaction chromatography (HIC) is frequently used for theAgilent Technologies, Inc.determination of drug-to-antibody ratio (DAR) of cysteine-linked antibody drugWaldbronn, Germanyconjugates (ADCs). The...
Key words
brentuximab, brentuximabvedotin, vedotindar, darhic, hicdrug, drugantibody, antibodyhydrophobic, hydrophobicmmae, mmaeadcs, adcsadc, adcinteraction, interactiontige, tigemab, mablinked, linkedcleavable
[ TECHNOLOGY BRIEF ]Analysis of Antibody Drug Conjugates (ADCs) by Native Mass Spectrometryon the BioAccord SystemHenry Shion, Ying Qing Yu, and Weibin ChenWaters Corporation, Milford, MA, USADrug-to-Antibody Ratio (DAR) determination of Lys andCys conjugated ADCs was accomplished using analyticalscale size...
Key words
bioaccord, bioaccordconjugated, conjugatedadc, adcdar, daradcs, adcsnative, nativedrug, drugantibody, antibodysystem, systemcovalent, covalentbrief, briefsec, secconjugates, conjugatescysteine, cysteinelysine
Analytical Scale Native SEC-MS for Antibody-Drug Conjugates(ADCs) CharacterizationHenry Shion, Ying Qing Yu, and Weibin ChenWaters Corporation, Milford, MA, USAAPPLICATION BENEFITS■■■■■■An improved native mass spectrometrywith analytical scale Size ExclusionChromatography (SEC) method isdeveloped for characterization ofcysteine-conjugated and lysineconjugated ADCs.This improved method offers...
Key words
adcs, adcsnative, nativesec, secdar, dardrug, drugantibody, antibodyhic, hicscale, scaleconjugated, conjugatedcharacterization, characterizationconjugates, conjugatesprotein, proteinuplc, uplcvion, vionconjugation
Automating the Determination of Drug-to-Antibody Ratio (DAR)of Antibody Drug Conjugates (ADCs) Based on Separationby Hydrophobic Interaction Chromatography (HIC)Robert Birdsall, Eoin Cosgrave, Henry Shion, and Weibin ChenWaters Corporation, Milford, MA, USAA P P L I C AT I O N B...
Key words
dar, darantibody, antibodyadcs, adcsdrug, drugconjugates, conjugatesautomating, automatingcalculations, calculationscqas, cqasratio, ratiodetermination, determinationhic, hicconjugated, conjugateduplc, uplcacquity, acquitycysteine
 

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