Antibody Drug Conjugate (ADC) Load Characterization and Analysis Using the BioAccord and Nano DSC Systems
Applications | 2020 | Waters Instrumentation
LC/TOF, LC/HRMS, LC/MS
IndustriesClinical Research
ManufacturerWaters
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Analysis of Antibody Drug Conjugates (ADCs) by Native Mass Spectrometry on the BioAccord System
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[ TECHNOLOGY BRIEF ]Analysis of Antibody Drug Conjugates (ADCs) by Native Mass Spectrometryon the BioAccord SystemHenry Shion, Ying Qing Yu, and Weibin ChenWaters Corporation, Milford, MA, USADrug-to-Antibody Ratio (DAR) determination of Lys andCys conjugated ADCs was accomplished using analyticalscale size...
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Analytical Scale Native SEC-MS for Antibody-Drug Conjugates(ADCs) CharacterizationHenry Shion, Ying Qing Yu, and Weibin ChenWaters Corporation, Milford, MA, USAAPPLICATION BENEFITS■■■■■■An improved native mass spectrometrywith analytical scale Size ExclusionChromatography (SEC) method isdeveloped for characterization ofcysteine-conjugated and lysineconjugated ADCs.This improved method offers...
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Automating the Determination of Drug-to-Antibody Ratio (DAR) of Antibody Drug Conjugates (ADCs) Based on Separation by Hydrophobic Interaction Chromatography (HIC)
2014|Waters|Applications
Automating the Determination of Drug-to-Antibody Ratio (DAR)of Antibody Drug Conjugates (ADCs) Based on Separationby Hydrophobic Interaction Chromatography (HIC)Robert Birdsall, Eoin Cosgrave, Henry Shion, and Weibin ChenWaters Corporation, Milford, MA, USAA P P L I C AT I O N B...
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