Antibody Drug Conjugate (ADC) Load Characterization and Analysis Using the BioAccord and Nano DSC Systems
Applications | 2020 | Waters Instrumentation
LC/TOF, LC/HRMS, LC/MSIndustries
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Analysis of Cysteine-Linked Antibody Drug Conjugates
Analysis of Cysteine-LinkedAntibody Drug ConjugatesUsing Hydrophobic Interaction Chromatography on theAgilent 1260 Infinity II Bio-inert LCApplication NoteBiologics and BiosimilarsAuthorAbstractSonja SchneiderHydrophobic interaction chromatography (HIC) is frequently used for theAgilent Technologies, Inc.determination of drug-to-antibody ratio (DAR) of cysteine-linked antibody drugWaldbronn, Germanyconjugates (ADCs). The...
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Analysis of Antibody Drug Conjugates (ADCs) by Native Mass Spectrometry on the BioAccord System
[ TECHNOLOGY BRIEF ]Analysis of Antibody Drug Conjugates (ADCs) by Native Mass Spectrometryon the BioAccord SystemHenry Shion, Ying Qing Yu, and Weibin ChenWaters Corporation, Milford, MA, USADrug-to-Antibody Ratio (DAR) determination of Lys andCys conjugated ADCs was accomplished using analyticalscale size...
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Analytical Scale Native SEC-MS for Antibody-Drug Conjugates (ADCs) Characterization
Analytical Scale Native SEC-MS for Antibody-Drug Conjugates(ADCs) CharacterizationHenry Shion, Ying Qing Yu, and Weibin ChenWaters Corporation, Milford, MA, USAAPPLICATION BENEFITS■■■■■■An improved native mass spectrometrywith analytical scale Size ExclusionChromatography (SEC) method isdeveloped for characterization ofcysteine-conjugated and lysineconjugated ADCs.This improved method offers...
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Automating the Determination of Drug-to-Antibody Ratio (DAR) of Antibody Drug Conjugates (ADCs) Based on Separation by Hydrophobic Interaction Chromatography (HIC)
Automating the Determination of Drug-to-Antibody Ratio (DAR)of Antibody Drug Conjugates (ADCs) Based on Separationby Hydrophobic Interaction Chromatography (HIC)Robert Birdsall, Eoin Cosgrave, Henry Shion, and Weibin ChenWaters Corporation, Milford, MA, USAA P P L I C AT I O N B...
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