An Automated Compliance-Ready LC-MS Workflow for Intact Mass Confirmation and Purity Analysis of Oligonucleotides
Applications | 2020 | WatersInstrumentation
LC/TOF, LC/HRMS, LC/MS
IndustriesPharma & Biopharma
ManufacturerWaters
Key wordsoligonucleotides, purity, compliance, intact, ready, confirmation, workflow, oligonucleotide, oligo, automated, mass, note, application, acquity, bioaccord, uplc, analysis, tic, chromatogram, tuv, therapeutics, composition, peak, employing, phosphorothioated, bayesian, oxygen, modified, plus, resist, system, detector, esi, reagents, class, waters, routines, tunable, unmodified, fidelity, atom, emerged, min, conference, rna, backbone, modifiers, monoisotopic, biomolecules, phosphorus
Similar PDF
Intact Mass Confirmation Analysis on the BioAccord LC-MS System for a Variety of Extensively Modified Oligonucleotides
2020|Waters|Applications
Application Note Intact Mass Confirmation Analysis on the BioAccord LC-MS System for a Variety of Extensively Modified Oligonucleotides Catalin E. Doneanu, Jonathan Fox, Emma Harry, Chris Knowles, Ying Qing Yu, Joseph Fredette, Weibin Chen Waters Corporation For research use only.…
Key words
oligonucleotides, oligonucleotidesmodified, modifiedoligonucleotide, oligonucleotideunmodified, unmodifiedisotopic, isotopicdeconvolution, deconvolutionbioaccord, bioaccordmodel, modelheavily, heavilyextensively, extensivelyppt, pptmodifications, modificationsoligo, oligosection, sectioncompliance
HILIC as an Alternative Separation Mode for Intact Mass Confirmation of Oligonucleotides on the BioAccord System
2021|Waters|Applications
Application Note HILIC as an Alternative Separation Mode for Intact Mass Confirmation of Oligonucleotides on the BioAccord System Catalin E. Doneanu, Ying Qing Yu, Joseph Fredette, William J. Warren, Weibin Chen Waters Corporation Abstract HILIC chromatography provides a clean, cost-effective…
Key words
oligonucleotides, oligonucleotidesbioaccord, bioaccordhilic, hilicintact, intactconfirmation, confirmationalternative, alternativeseparation, separationmass, massmode, modeoligonucleotide, oligonucleotidesystem, systemost, ostamide, amidebeh, behcharge
Analysis of Oligonucleotide Impurities on the BioAccord System with ACQUITY Premier
2021|Waters|Applications
Application Note Analysis of Oligonucleotide Impurities on the BioAccord System with ACQUITY Premier Catalin E. Doneanu, Chris Knowles, Jonathan Fox, Emma Harry, Ying Qing Yu, Joseph Fredette, Weibin Chen Waters Corporation Abstract This application note demonstrates an automated, compliance-ready LC-MS…
Key words
oligonucleotide, oligonucleotidebioaccord, bioaccordpremier, premieracquity, acquityimpurities, impuritiessystem, systemanalysis, analysisost, ostoligonucleotides, oligonucleotidesconfirmation, confirmationpreceding, precedingintact, intactimpurity, impurityfluidic, fluidichps
TIDES: AN AUTOMATED WORKFLOW FOR INTACT MASS, PURITY AND SEQUENCE CONFIRMATION OF SYNTHETIC OLIGONUCLEOTIDES AND THEIR IMPURITIES
2023|Waters|Posters
AN AUTOMATED WORKFLOW FOR INTACT MASS, PURITY AND SEQUENCE CONFIRMATION OF SYNTHETIC OLIGONUCLEOTIDES AND THEIR IMPURITIES Catalin Doneanu1, Chris Knowles2, Matthew Gorton2, Joe Fredette1 and Ying Qing Yu1 1 Waters Corporation, Milford, MA USA; 2Waters Corporation, Wilmslow, UK RESULTS OVERVIEW…
Key words
auu, auuutt, uttagu, agucca, ccaaag, aagacc, accgua, guaoligonucleotide, oligonucleotideoligonucleotides, oligonucleotidessequence, sequencebioaccordtm, bioaccordtmsynthetic, syntheticcoverage, coverageprecursor, precursoratdbio