Rapid, Sensitive, and Routine Intact mAb Quantification using a Compact Tof HRMS PlatformPosters | 2019 | WatersInstrumentationLC/TOF, LC/HRMS, LC/MSIndustriesPharma & BiopharmaManufacturerWatersKey wordsbsa, idc, rda, intact, plasma, bioaccord, trastuzumab, quantification, extracted, matrix, uplc, uloq, goat, streptavidin, final, matrixes, immobilized, easy, good, statistics, attractive, level, system, mouse, anti, shift, compact, qtof, hrms, assessed, fitting, performance, recently, antibody, coated, quantified, file, theoretical, use, charge, lod, minimal, state, mean, introduced, platform, loq, acquity, tof, general
HRMS System Check for Intact Protein Quantification
HRMS System Check for Intact Protein QuantificationArmand Ngounou, Yun Alelyunas, and Mark WronaWaters Corporation, Milford, MA, USAAPPLICATION BENEFITS■■■■A system check (SC) ensures properIn recent years, there has been a significant increase in interest in thesetup for intact protein bioanalysis(direct) bioanalysis...
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Comparison of Tandem and High Resolution Mass Spectrometry for the Quantification of the Monoclonal Antibody, Trastuzumab in Plasma
[ TECHNOLOGY BRIEF ]Comparison of Tandem and High Resolution Mass Spectrometry for theQuantification of the Monoclonal Antibody, Trastuzumab in PlasmaMary Lame, Caitlin Dunning, Yun Alelyunas, and Mark WronaWaters Corporation, Milford, MA, USADemand for bioanalytical quantification of proteins viaLC-MS has steadily...
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High Sensitivity Intact Monoclonal Antibody (mAb) HRMS Quantification
High Sensitivity Intact Monoclonal Antibody (mAb) HRMS QuantificationYun Wang Alelyunas, Henry Shion, Mark WronaWaters Corporation, Milford, MA, USAAPPLICATION BENEFITS■■■■INTRODUCTIONmAb LC-MS method which enablesBiotherapeutics have emerged as one of the major sources of innovativeusers to achieve highly sensitivemedicines in drug discovery...
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PEPTIDE AND PROTEIN BIOANALYSIS
[ APPLICATION NOTEBOOK ]PEPTIDE AND PROTEINBIOANALYSIS[ OUR SCIENTISTS ]Yun Alelyunas, PhDBefore coming to Waters in 2012, YunAlelyunas was a principal scientist and teamleader at AstraZeneca for 20 years whereshe was involved in industrial chemicalanalysis, in vitro ADME screening, andproject core...
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