LCMS
More information
WebinarsAbout usContact usTerms of use
LabRulez s.r.o. All rights reserved. Content available under a CC BY-SA 4.0 Attribution-ShareAlike
Author
Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences
Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences
The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry.
Tags
Article
Science and research
Video
LinkedIn Logo

IOCB Prague unveils a fundamentally faster, more affordable way to produce quantum-grade nanodiamonds

Fr, 7.11.2025
| Original article from: IOCB Prague
IOCB Prague scientists led by Dr. Petr Cígler developed a method to create quantum nanodiamonds within minutes—over 1,000× faster than before, paving the way for affordable large-scale nanosensor production.
Video placeholder
  • Photo: Tomáš Belloň/IOCB Prague: Dr. Petr Cígler, head of the Synthetic Nanochemistry research group, and Dr. Michal Gulka, first author of the study
  • Video: IOCB Prague: IOCB Prague unveils a fundamentally faster, affordable production of quantum grade nanodiamonds

An international team of scientists from three continents led by Dr. Petr Cígler of IOCB Prague has developed a method for creating light-emitting quantum centers in nanodiamonds in only a matter of minutes. In just one week, the process can yield as much material as conventional methods would produce in more than forty years. Moreover, the resulting nanodiamonds show improved optical and quantum properties. The breakthrough brings us one step closer to the industrial production of higher-quality and more affordable quantum nanodiamonds, which have broad applications in research and technology. The article was published in the scientific journal Advanced Functional Materials.

omáš Belloň/IOCB Prague: Dr. Petr Cígler, head of the Synthetic Nanochemistry research group, and Dr. Michal Gulka, first author of the studyomáš Belloň/IOCB Prague: Dr. Petr Cígler, head of the Synthetic Nanochemistry research group, and Dr. Michal Gulka, first author of the study

The research team has introduced a new procedure called Pressure and Temperature Qubits (PTQ), which takes only four minutes. Diamond powder is placed in a press that generates extremely high pressure and temperature, reproducing the conditions found deep within the Earth’s mantle. Under these conditions, quantum centers are formed inside the nanodiamonds. To prevent the particles from fusing together, ordinary table salt is added. It melts during heating, creating a protective environment. After the process, the salt is simply removed with water, leaving a pure, luminescent material.

We’ve accelerated the creation of quantum centers in nanodiamonds more than a thousandfold compared with the standard procedure. Until now, diamond powder had to be irradiated with a beam of charged particles for two weeks and then annealed at high temperature. The result was less than a gram of usable material. We can now produce it in kilograms,” says Dr. Michal Gulka, a postdoctoral researcher in Petr Cígler’s group and first author of the study.

IOCB Prague: The apparatus in which the luminescent nanodiamonds were prepared.IOCB Prague: The apparatus in which the luminescent nanodiamonds were prepared.

Nanodiamonds are particles smaller than a virus that are used in advanced diagnostics to measure magnetic fields, charge, or temperature. They function as highly sensitive sensors thanks to a nitrogen-vacancy (NV) center – a nitrogen atom located next to a missing carbon atom in the diamond lattice. The NV center is fluorescent, meaning that when illuminated, it emits light. The intensity and timing of this light depend on changes in the surrounding environment, allowing nanodiamonds to detect even individual molecules or measure temperature inside cells.

A key contributor to the project is the American company MegaDiamond, which plans to launch industrial production of these nanosensors.

Thanks to the new method, laboratories and companies around the world can obtain large quantities of high-quality nanodiamonds with NV centers, which opens the door to new technologies – from precision sensors for medical diagnostics to local molecular detectors based on principles such as magnetic resonance,” adds Dr. Petr Cígler.

The study was supported in part by the AMULET project, which focuses on developing multiscale nanomaterials and brings together eight partners led by the J. Heyrovský Institute of Physical Chemistry. Funding was provided through the Jan Amos Komenský Operational Programme of the Czech Ministry of Education, Youth and Sports, under the Excellent Research category.

IOCB Prague: The standard procedure for creating NV (nitrogen vacancy) quantum centers in nanodiamonds involves costly irradiation in particle accelerators and annealing. It is both laborious and time-consuming. The new method, which uses plastic deformation under extremely high temperature and pressure, produces both red-emitting NV centers and green-emitting H3 centers. Moreover, it repairs the diamond lattice, resulting in particles with a more stable charge state, higher magnetic resonance (MR) contrast, and improved spin properties of the NV centers, which enables more sensitive and accurate measurements.IOCB Prague: The standard procedure for creating NV (nitrogen vacancy) quantum centers in nanodiamonds involves costly irradiation in particle accelerators and annealing. It is both laborious and time-consuming. The new method, which uses plastic deformation under extremely high temperature and pressure, produces both red-emitting NV centers and green-emitting H3 centers. Moreover, it repairs the diamond lattice, resulting in particles with a more stable charge state, higher magnetic resonance (MR) contrast, and improved spin properties of the NV centers, which enables more sensitive and accurate measurements.

The original article

Quantum‐Grade Nanodiamonds from a Single‐Step, Industrial‐Scale Pressure and Temperature Process

Yahua Bao, Michal Gulka, Parkarsh Kumar, Jakub Copak, Priyadharshini Balasubramanian, Yuliya Mindarava, Rémi Blinder, Michael Olney-Fraser, Haotian Wen, Hana Spanielova, Helen Zhi Jie Zeng, Benjamin Whitefield, Igor Aharonovich, Jaroslav Hruby, Fedor Jelezko, J. Daniel Belnap, Shery L. Y. Chang, Petr Cigler

Adv. Funct. Mater. 2025

https://doi.org/10.1002/adfm.202520907 

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences
LinkedIn Logo
 

Related content

Overcoming Strong Solvent Effects in the Analysis of Vepdegestrant

Applications
| 2026 | Agilent Technologies
Instrumentation
HPLC
Manufacturer
Agilent Technologies
Industries
Pharma & Biopharma

Identification of Double Bond Positions and Relative Acyl Chain Positions in Egg Yolk Phosphatidylcholines Using OAD-TOF System

Applications
| 2026 | Shimadzu
Instrumentation
LC/MS, LC/MS/MS, LC/TOF, LC/HRMS
Manufacturer
Shimadzu
Industries
Food & Agriculture

High Molecular-Weight Polysaccharide Characterization by SEC-MALS Using GTxResolve™ 1000 and 2000 Å SEC Columns

Applications
| 2026 | Waters
Instrumentation
GPC/SEC, Consumables, LC columns
Manufacturer
Waters
Industries
Pharma & Biopharma, Food & Agriculture

Development and Optimization for a Comprehensive LC/MS/MS Method for the Detection of 74 PFAS Compounds

Applications
| 2026 | Agilent Technologies
Instrumentation
LC/MS, LC/MS/MS, LC/QQQ
Manufacturer
Agilent Technologies
Industries
Food & Agriculture

PFAS in Biota: Risk Context & Robust Analytical Solutions

Others
| 2026 | ALS Europe
Instrumentation
Laboratory analysis, LC/MS, LC/MS/MS
Manufacturer
Industries
Environmental
 

Related articles

JUNIOR STAR Grants at UCT Prague: Two talented women from abroad driving innovation in science
Article | Scientists

JUNIOR STAR Grants at UCT Prague: Two talented women from abroad driving innovation in science

Two outstanding early-career researchers at UCT Prague, Filipa Oliveira and Stella Gonsales, received prestigious GAČR JUNIOR STAR grants for innovative research in materials science and sustainable chemistry.
UCT Prague
tag
share
more
Research from IOCB Prague reveals a previously unknown mechanism of genetic transcription
Article | Science and research

Research from IOCB Prague reveals a previously unknown mechanism of genetic transcription

Scientists at IOCB Prague reveal a previously unknown mechanism that initiates gene transcription. Using cryo-EM, they uncover how alarmone molecules enable RNA synthesis under stress.
Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences
tag
share
more
Food Adulteration and How It Is Revealed by Analytical Chemistry
Article | Food

Food Adulteration and How It Is Revealed by Analytical Chemistry

Food adulteration threatens quality and consumer trust. Discover how HPLC and modern chromatographic systems from Watrex Praha help identify oil, honey, and wine adulteration with high confidence.
Watrex Praha
tag
share
more
Affinity, Gel Filtration, Size Exclusion Chromatography: Repurposing Kinase Inhibitors for Malaria
Interview | Video

Affinity, Gel Filtration, Size Exclusion Chromatography: Repurposing Kinase Inhibitors for Malaria

This podcast explores how chromatography (FPLC/SEC) and mass spectrometry support malaria drug discovery, from protein purification and QC to interaction studies and complex sample preparation.
Organomation
tag
share
more
 

Related content

Overcoming Strong Solvent Effects in the Analysis of Vepdegestrant

Applications
| 2026 | Agilent Technologies
Instrumentation
HPLC
Manufacturer
Agilent Technologies
Industries
Pharma & Biopharma

Identification of Double Bond Positions and Relative Acyl Chain Positions in Egg Yolk Phosphatidylcholines Using OAD-TOF System

Applications
| 2026 | Shimadzu
Instrumentation
LC/MS, LC/MS/MS, LC/TOF, LC/HRMS
Manufacturer
Shimadzu
Industries
Food & Agriculture

High Molecular-Weight Polysaccharide Characterization by SEC-MALS Using GTxResolve™ 1000 and 2000 Å SEC Columns

Applications
| 2026 | Waters
Instrumentation
GPC/SEC, Consumables, LC columns
Manufacturer
Waters
Industries
Pharma & Biopharma, Food & Agriculture

Development and Optimization for a Comprehensive LC/MS/MS Method for the Detection of 74 PFAS Compounds

Applications
| 2026 | Agilent Technologies
Instrumentation
LC/MS, LC/MS/MS, LC/QQQ
Manufacturer
Agilent Technologies
Industries
Food & Agriculture

PFAS in Biota: Risk Context & Robust Analytical Solutions

Others
| 2026 | ALS Europe
Instrumentation
Laboratory analysis, LC/MS, LC/MS/MS
Manufacturer
Industries
Environmental
 

Related articles

JUNIOR STAR Grants at UCT Prague: Two talented women from abroad driving innovation in science
Article | Scientists

JUNIOR STAR Grants at UCT Prague: Two talented women from abroad driving innovation in science

Two outstanding early-career researchers at UCT Prague, Filipa Oliveira and Stella Gonsales, received prestigious GAČR JUNIOR STAR grants for innovative research in materials science and sustainable chemistry.
UCT Prague
tag
share
more
Research from IOCB Prague reveals a previously unknown mechanism of genetic transcription
Article | Science and research

Research from IOCB Prague reveals a previously unknown mechanism of genetic transcription

Scientists at IOCB Prague reveal a previously unknown mechanism that initiates gene transcription. Using cryo-EM, they uncover how alarmone molecules enable RNA synthesis under stress.
Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences
tag
share
more
Food Adulteration and How It Is Revealed by Analytical Chemistry
Article | Food

Food Adulteration and How It Is Revealed by Analytical Chemistry

Food adulteration threatens quality and consumer trust. Discover how HPLC and modern chromatographic systems from Watrex Praha help identify oil, honey, and wine adulteration with high confidence.
Watrex Praha
tag
share
more
Affinity, Gel Filtration, Size Exclusion Chromatography: Repurposing Kinase Inhibitors for Malaria
Interview | Video

Affinity, Gel Filtration, Size Exclusion Chromatography: Repurposing Kinase Inhibitors for Malaria

This podcast explores how chromatography (FPLC/SEC) and mass spectrometry support malaria drug discovery, from protein purification and QC to interaction studies and complex sample preparation.
Organomation
tag
share
more
 

Related content

Overcoming Strong Solvent Effects in the Analysis of Vepdegestrant

Applications
| 2026 | Agilent Technologies
Instrumentation
HPLC
Manufacturer
Agilent Technologies
Industries
Pharma & Biopharma

Identification of Double Bond Positions and Relative Acyl Chain Positions in Egg Yolk Phosphatidylcholines Using OAD-TOF System

Applications
| 2026 | Shimadzu
Instrumentation
LC/MS, LC/MS/MS, LC/TOF, LC/HRMS
Manufacturer
Shimadzu
Industries
Food & Agriculture

High Molecular-Weight Polysaccharide Characterization by SEC-MALS Using GTxResolve™ 1000 and 2000 Å SEC Columns

Applications
| 2026 | Waters
Instrumentation
GPC/SEC, Consumables, LC columns
Manufacturer
Waters
Industries
Pharma & Biopharma, Food & Agriculture

Development and Optimization for a Comprehensive LC/MS/MS Method for the Detection of 74 PFAS Compounds

Applications
| 2026 | Agilent Technologies
Instrumentation
LC/MS, LC/MS/MS, LC/QQQ
Manufacturer
Agilent Technologies
Industries
Food & Agriculture

PFAS in Biota: Risk Context & Robust Analytical Solutions

Others
| 2026 | ALS Europe
Instrumentation
Laboratory analysis, LC/MS, LC/MS/MS
Manufacturer
Industries
Environmental
 

Related articles

JUNIOR STAR Grants at UCT Prague: Two talented women from abroad driving innovation in science
Article | Scientists

JUNIOR STAR Grants at UCT Prague: Two talented women from abroad driving innovation in science

Two outstanding early-career researchers at UCT Prague, Filipa Oliveira and Stella Gonsales, received prestigious GAČR JUNIOR STAR grants for innovative research in materials science and sustainable chemistry.
UCT Prague
tag
share
more
Research from IOCB Prague reveals a previously unknown mechanism of genetic transcription
Article | Science and research

Research from IOCB Prague reveals a previously unknown mechanism of genetic transcription

Scientists at IOCB Prague reveal a previously unknown mechanism that initiates gene transcription. Using cryo-EM, they uncover how alarmone molecules enable RNA synthesis under stress.
Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences
tag
share
more
Food Adulteration and How It Is Revealed by Analytical Chemistry
Article | Food

Food Adulteration and How It Is Revealed by Analytical Chemistry

Food adulteration threatens quality and consumer trust. Discover how HPLC and modern chromatographic systems from Watrex Praha help identify oil, honey, and wine adulteration with high confidence.
Watrex Praha
tag
share
more
Affinity, Gel Filtration, Size Exclusion Chromatography: Repurposing Kinase Inhibitors for Malaria
Interview | Video

Affinity, Gel Filtration, Size Exclusion Chromatography: Repurposing Kinase Inhibitors for Malaria

This podcast explores how chromatography (FPLC/SEC) and mass spectrometry support malaria drug discovery, from protein purification and QC to interaction studies and complex sample preparation.
Organomation
tag
share
more
 

Related content

Overcoming Strong Solvent Effects in the Analysis of Vepdegestrant

Applications
| 2026 | Agilent Technologies
Instrumentation
HPLC
Manufacturer
Agilent Technologies
Industries
Pharma & Biopharma

Identification of Double Bond Positions and Relative Acyl Chain Positions in Egg Yolk Phosphatidylcholines Using OAD-TOF System

Applications
| 2026 | Shimadzu
Instrumentation
LC/MS, LC/MS/MS, LC/TOF, LC/HRMS
Manufacturer
Shimadzu
Industries
Food & Agriculture

High Molecular-Weight Polysaccharide Characterization by SEC-MALS Using GTxResolve™ 1000 and 2000 Å SEC Columns

Applications
| 2026 | Waters
Instrumentation
GPC/SEC, Consumables, LC columns
Manufacturer
Waters
Industries
Pharma & Biopharma, Food & Agriculture

Development and Optimization for a Comprehensive LC/MS/MS Method for the Detection of 74 PFAS Compounds

Applications
| 2026 | Agilent Technologies
Instrumentation
LC/MS, LC/MS/MS, LC/QQQ
Manufacturer
Agilent Technologies
Industries
Food & Agriculture

PFAS in Biota: Risk Context & Robust Analytical Solutions

Others
| 2026 | ALS Europe
Instrumentation
Laboratory analysis, LC/MS, LC/MS/MS
Manufacturer
Industries
Environmental
 

Related articles

JUNIOR STAR Grants at UCT Prague: Two talented women from abroad driving innovation in science
Article | Scientists

JUNIOR STAR Grants at UCT Prague: Two talented women from abroad driving innovation in science

Two outstanding early-career researchers at UCT Prague, Filipa Oliveira and Stella Gonsales, received prestigious GAČR JUNIOR STAR grants for innovative research in materials science and sustainable chemistry.
UCT Prague
tag
share
more
Research from IOCB Prague reveals a previously unknown mechanism of genetic transcription
Article | Science and research

Research from IOCB Prague reveals a previously unknown mechanism of genetic transcription

Scientists at IOCB Prague reveal a previously unknown mechanism that initiates gene transcription. Using cryo-EM, they uncover how alarmone molecules enable RNA synthesis under stress.
Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences
tag
share
more
Food Adulteration and How It Is Revealed by Analytical Chemistry
Article | Food

Food Adulteration and How It Is Revealed by Analytical Chemistry

Food adulteration threatens quality and consumer trust. Discover how HPLC and modern chromatographic systems from Watrex Praha help identify oil, honey, and wine adulteration with high confidence.
Watrex Praha
tag
share
more
Affinity, Gel Filtration, Size Exclusion Chromatography: Repurposing Kinase Inhibitors for Malaria
Interview | Video

Affinity, Gel Filtration, Size Exclusion Chromatography: Repurposing Kinase Inhibitors for Malaria

This podcast explores how chromatography (FPLC/SEC) and mass spectrometry support malaria drug discovery, from protein purification and QC to interaction studies and complex sample preparation.
Organomation
tag
share
more
Other projects
GCMS
ICPMS
Follow us
More information
WebinarsAbout usContact usTerms of use
LabRulez s.r.o. All rights reserved. Content available under a CC BY-SA 4.0 Attribution-ShareAlike