Agilent 6460 Triple Quadrupole LC/MS (G6460C) (Refurbished)

The Agilent 6460 Triple Quadrupole LC/MS system offers cutting-edge performance for quantitative analyses in research and industry. Engineered for high sensitivity, robustness, and speed, the system is equipped with Agilent Jet Stream Technology, providing exceptional signal-to-noise ratios (S/N) and low instrument detection limits (IDL).

Designed for a wide range of applications, the 6460 delivers reproducible, trace-level quantitation with rapid polarity switching and precision tuning. Its compatibility with multiple ionization modes and integration with Agilent’s MassHunter software ensures streamlined workflows and advanced data analysis.

Technical Specifications of the Agilent 6460 Triple Quadrupole LC/MS

Performance

• MRM Sensitivity (Signal-to-Noise Ratio):
  • Positive Mode (ESI): S/N > 30,000:1 for 1 pg reserpine.
  • Negative Mode (ESI): S/N > 10,000:1 for 1 pg chloramphenicol.
• Instrument Detection Limit (IDL):
  • <12.5 fg for reserpine or chloramphenicol (ESI positive/negative).

Mass Range and Resolution

• Mass Range: m/z 5–3,000.
• Mass Resolution:
  • Autotune: Full Width at Half Maximum (FWHM) = 0.7 Da.
  • Manual Tune: FWHM = 0.5 Da.
• Mass Accuracy: ±0.1 Da (5–1,000 m/z); 0.01%–0.02% for higher ranges.
• Mass Stability: < 0.1 Da over 24 hours.

Ionization Sources

• Electrospray Ionization (ESI) (Standard).
• Atmospheric Pressure Chemical Ionization (APCI) (Optional).
• Multimode Source (simultaneous ESI and APCI) (Optional).
• Atmospheric Pressure Photo Ionization (APPI) (Optional).
• Nanospray Interface (HPLC-Chip Cube) (Optional).

MRM and Scan Modes

• Scan Modes: MS scan, MS/MS product ion scan, MRM, neutral loss/gain scan, and precursor ion scan.
• Dynamic Range: >6.0 × 10⁶.
• MRM Transitions:
  • 450 transitions per time segment.
  • Up to 40,000 ion transactions per method.
• Polarity Switching: 30 ms.

Vacuum and Detection System

• Vacuum: Two turbomolecular pumps with one mechanical pump.
• Detector: High-energy conversion dynode with high-gain electron multiplier horn.

General Features

• Scan Rate: Up to 12,500 Da/s.
• Software Integration: Controlled via MassHunter Workstation Software.
• Autotune: Automatic ion optics optimization and calibration in positive and negative modes.

System Requirements

• Dimensions and Weight: Configurations depend on setup and installation.
• Power Requirements: Standard laboratory AC power supply.
• Compatibility: Compatible with Agilent 1100, 1200, 1260, 1290 and later HPLC systems. Control and data processing via MassHunter.

The Agilent 6460 combines precision, versatility, and ease of operation, making it an essential tool for high-performance quantitative analysis.