SCIEX API 4000 LC-MS/MS System (Refurbished)

The SCIEX API 4000 is a triple quadrupole LC-MS/MS system designed for highly sensitive and selective quantitative analysis. Widely adopted in pharmaceutical, clinical, food safety, and environmental laboratories, the API 4000 is recognized for its robustness, reliability, and ability to deliver reproducible data across demanding applications. It is especially suitable for bioanalysis, drug metabolism, pharmacokinetics, and trace-level contaminant detection.

Complete system

• SCIEX API 4000 mass spectrometer
• Turbo V source ESI
• Rotary vacuum pump Pump Edwards 28
• Workstation + software analyst 1.6.3

Key Features

• Triple Quadrupole Design: High sensitivity and selectivity for quantitative LC-MS/MS workflows.
• Proven Reliability: Robust platform with a strong reputation in regulated bioanalytical labs.
• Dynamic Range: Wide linear dynamic range for accurate quantitation across low and high concentration samples.
• Application Versatility: Supports pharmaceutical, clinical, food, and environmental testing.
• Efficient Ionization: TurboIonSpray® and APCI sources available for diverse compound classes.
• Data Quality: Low limits of quantitation (LLOQs) with excellent reproducibility.
• Regulatory Compliance: Suitable for 21 CFR Part 11 environments when paired with SCIEX Analyst® software.

Technical Specifications

• Model: SCIEX API 4000
• Mass Analyzer Type: Triple Quadrupole
• Mass Range: m/z 5 – 2000 (typical)
• Ionization Sources: TurboIonSpray®, APCI (optional)
• Polarity Switching: Fast, <50 ms
• Scan Modes: MRM (Multiple Reaction Monitoring), product ion, precursor ion, neutral loss, SIM
• Sensitivity: Sub-pg to low-fg detection limits (compound dependent)
• Dynamic Range: Up to 5 orders of magnitude
• Applications: Bioanalysis, PK/PD studies, metabolite ID, food safety, environmental monitoring, clinical research
• Software: Analyst® for instrument control, data acquisition, and processing
• Integration: Compatible with LC systems from multiple vendors