14th Multidimensional Chromatography Workshop (MDCW)
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14th Multidimensional Chromatography Workshop (MDCW)
he 14th MDCW in 2023 was held in person in Liege, Belgium and incorporated a live stream option. Notable events in 2023 included the first in-person poster session and the first session held on ASTM method development for GCxGC methods.
💡 Download 14th Multidimensional Chromatography Workshop Guidebook
💡 Recordings of lectures available at YouTube playlist The Multidimensional Chromatography (MDC) Workshop
💡 Further information can be found on The Multidimensional Chromatography (MDC) Workshop profiles on LabRulezGCMS and LabRulezLCMS portals
Awards 2023
The American Chemical Society Subdivision of Chromatography and Separations Chemistry sponsors two student poster awards with a prize of $250 USD each.
MDCW: GCxGC Poster Prize 2023: P04 Development of a valve-based GC×GC-QMS instrument for highly volatile sample analysis (Lina Mikaliunaite)
Sponsors 2023
MDCW: Sponsors 14th Multidimensional Chromatography Workshop
Keynote Speakers 2023
Dr. Petr Vozka
- Assistant Professor, California State University, Los Angeles
- Title of Keynote Lecture: Quantitative Analysis of Aliphatic Olefins in Fuels made from Plastic Waste by Comprehensive Two-Dimensional Gas Chromatography
- LabRulezGCMS profile
Petr Vozka is an Assistant Professor of Analytical Chemistry at the California State University, Los Angeles (CSULA). He obtained his Ph.D. in 2019 from Purdue University. He is also the Director of the Complex Chemical Composition Analysis Lab (C3AL). His research focuses on the characterization of complex chemical mixtures via state-of-the-art techniques, such as two-dimensional gas chromatography and high-resolution mass spectrometry. His primary focus is on developing methods for analyzing products from plastic waste conversion processes and organic compounds adsorbed on microplastics. He has 1 patent, 6 military reports, 23 journal publications, and 27 research presentations which include 10 invited lectures and invited presentations.
Dr. Bob W.J. Pirok
- Assistant Professor, University of Amsterdam
- Title of Keynote Lecture: Challenges to Achieve Unsupervised Optimization of Heart-cut and Comprehensive Two-dimensional Liquid Chromatography Separations
Bob Pirok obtained his PhD cum laude in 2019 in Amsterdam and worked before at Shell. He is currently Assistant Professor at the University of Amsterdam and focuses on the application of chemometrics to analytical chemistry with a special interest in method development and data analysis for multi-dimensional chromatography. He is visiting professor at Gustavus Adolphus College and received a number of international recognitions including the Csaba-Horvath Young Scientist Award at HPLC2017 in Prague.
Dr. Taylor Hayward
- Principal Scientist, Apeel Sciences
- Title of Keynote Lecture: Assessment of Fruit Quality Through Volatile Aalysis Using SPME and Thermal Desorption With GC×GC-TOFMS
Taylor Hayward is a Principal Scientist at Apeel Sciences in Santa Barbara, California as part of the Apeel Labs team. Apeel Sciences is an agricultural technology company that focuses on prevention of food waste, and the Apeel Labs team focuses on research efforts to improve and advance technologies at Apeel. This includes using analytical techniques such as multidimensional gas and liquid chromatography, mass spectrometry, spectroscopy, and other sensors to gain a fundamental understanding of produce physiology and quality.
Dr. Arnaud Delobel
- R&D and Innovation Director, Quality Assistance SA
- Title of Keynote Lecture: 2D-LC/MS in a regulated biopharma environment: challenges and applications
Arnaud Delobel is the R&D and Innovation Director at Quality Assistance. He graduated from ECPM Strasbourg and specialized in mass spectrometry of proteins and peptides during his PhD at the CNRS in Gif-sur-Yvette (France). After a post-doc in Liège (Belgium) focused on proteomics, he joined Quality Assistance in 2006, and held several positions in the company to eventually become R&D and Innovation Director in 2016. As the head of the R&D Department, he is responsible for supervising internal R&D projects, aiming at implementing new analytical technologies that will ultimately be provided by Quality Assistance to their customers. He is also supervising the work of Product Experts who identify market needs with input from the Management, Regulatory Affairs Manager and external experts, and from any relevant data gathered by Quality Assistance, and that are responsible for interpreting and translating this intelligence into developing new R&D services.
Guided Discussion Groups
Removing the barriers from adoption of comprehensive two-dimensional chromatography
- Caitlin N. Cain, Timothy J. Trinklein, Sonia Schöneich, Grant S. Ochoa, and Lina Mikaliunaite (Department of Chemistry, University of Washington, Seattle, WA, USA)
- Soraya Chapel (KU Leuven, Leuven, Belgium)
Comprehensive two-dimensional gas (GC×GC) and liquid (LC×LC) chromatography are well-established separation techniques that exhibit enhanced resolving power over their one-dimensional counterparts. With improvements in commercial instrumentation and data analysis platforms, performing a GC×GC or LC×LC separation and analyzing its output are easier now than ever before. However, despite these developments, the broader analytical community often perceives comprehensive two-dimensional chromatography as complex, difficult, and intimidating. How do we address this stereotype and make these separation techniques approachable to the broader community? Following each step in the established analytical workflow, this discussion group will identify common misconceptions about instrumentation, method development/optimization, and data analysis. By addressing these concerns, this discussion will aim to instill confidence in analysts and provide them tools for applying these separation methods to various application areas.
GCxGC, will it ever be in common use in the petroleum laboratories?
- Lenny Kouwenhoven, Jop Bezuijen (Petroleum Analyzer Company)
- Christina Kelly (LECO Corporation)
- Jon Sims (Exxon)
Legislation, commercial contracts or process control require standardized methods or procedures to ensure product results from all parties involved can be compared to meet contract requirements and resolve disputes.
Standardized method development and adoption is a collaborative process which requires buy-in from many competing interests before new methods are accepted. Innovative or unfamiliar technologies need to overcome market resistance to change, bureaucratic inertia within standardization committees, and the tendency of legacy market suppliers to protect their economic interest. All of these pre-existing stakeholders need to be brought into agreement to allow the new technology into the market space. With these difficulties as background, Lenny Kouwenhoven will talk about her real world experience in bringing the first GCxGC test method for the petroleum market through the ASTM method development process. In addition, the first preliminary ILS data for the GCxGC method will be presented and discussed. The path forward for European and Asian adoption will be overviewed and contrasted with ASTM procedures.
Full Program MDCW 2023
MONDAY JANUARY 30, 2023
8:30 - 9:00 AM Registration
9:00 - 9:30 AM Opening Remarks
9:30 - 10:00 AM KL01 Petr Vozka - Quantitative analysis of aliphatic olefins in fuels made from plastic waste by comprehensive twodimensional gas chromatography
MDCW: Quantitative analysis of aliphatic olefins in fuels made from plastic waste by comprehensive twodimensional gas chromatography (Petr Vozka)
10:00 - 10:30 AM KL02 Bob Pirok - Challenges to achieve unsupervised optimization of heart-cut and comprehensive two-dimensional liquid chromatography separations
10:30 - 11:00 AM Coffee Break
11:00 - 11:20 AM OL01 Marie Pardon - Systematic study of a selective comprehensive two-dimensional liquid chromatography interface with active solvent modulation to overcome the mobile phase incompatibility between HILIC and RPLC
11:20 - 11:40 AM OL02 Ali Amini - Prototyping microfluidic devices for spatial multi-dimensional liquid chromatography by using Digital light processing 3D-printing
11:40 - 12:00 PM OL03 Turaj Rahmani - Hyphenation of temperatureresponsive chromatography and ultrafast chiral chromatography as a generic comprehensive two-dimensional method for the analysis of chiral pharmaceuticals
12:00 - 12:20 PM OL04 Giorgia Purcaro - LC-GC×GC-TOF MS/FID: a powerful multidimensional technique for automated and reliable characterization of complex samples
12:20 - 1:30 PM Lunch sponsored by Agilent
1:30 - 1:50 PM OL05 Grant Ochoa - Developing advanced chemometric analysis methods for GC×GC-TOFMS to facilitate in-depth jet and rocket fuel characterization
1:50 - 2:10 PM OL06 Laura McGregor - Comprehensive analysis of vehicle emissions using thermal desorption (TD) and GC×GC–TOF MS
2:10 - 2:30 PM OL07 Eliane Lazzari - Qualitative screening of catalytic pyrolysis wood-oil by means of GC×GC-TOFMS and soft ionization
2:30 - 2:50 PM OL08 Romaine Klein - Characterization of automobile material emissions by TD-GC×GC-TOFMS and correlation with odor hedonic perception in humans
2:50 - 3:50 PM Coffee Break and Poster session
3:50 - 5:20 PM Guided Discussion 1: Removing the barriers from adoption of comprehensive two-dimensional chromatography
- Caitlin N. Cain, Timothy J. Trinklein, Sonia Schöneich, Grant S. Ochoa, Lina Mikaliunaite, and Soraya Chapel
6:30 PM Conference cocktail (Aquarium-Muséum Universitaire de Liège)
TUESDAY JANUARY 31, 2023
8:30 - 9:00 AM Registration
9:00 - 9:15 AM Opening Remarks
9:15 - 9:45 AM KL03 Arnaud Delobel - 2D-LC/MS in a regulated biopharma environment: Challenges and applications
9:45 - 10:15 AM KL04 Taylor Hayward - Assessment of fruit quality through volatile analysis using SPME and thermal desorption with GC×GC-TOFMS
10:15 - 10:35 AM FL01 Christina Kelly - Simplifying method development for routine petroleum analysis using flow-modulated GC×GCMS/FID
FL02 Agathe Legendre - Renewable gases exploration by TD-GC×GC-TOFMS
10:35 - 11:05 AM Coffee Break sponsored by JEOL
11:05 - 11:25 AM OL09 Jan Leppert - Modular simulation of complex gas chromatographic systems
11:25 - 11:45 AM OL10 Timothy Trinklein - Simulating GC×GC-TOFMS data with realistic run-to-run shifting to evaluate the robustness of chemometric software
11:45 - 12:05 PM OL11 Daniel Geschwender - Automated alignment for quantitative pairwise differencing of two-dimensional chromatography data
12:05 - 12:25 PM OL12 John Dane - A new generation high resolution MS for GC×GC analysis
12:25 - 1:30 PM Lunch
1:30 - 1:50 PM FL03 Caitlin Cain - Discovering compositional differences between aerospace fuels using comprehensive twodimensional chromatography with time-of-flight mass spectrometry and chemometrics
FL04 Nemanja Koljančić - Food metabolomics by GC×GCTOF MS and tandem ionization: Understanding the impact of climate events on edible crops quality
1:50 - 2:10 PM FL05 Elsa Boudard - Sampling body odor for healthcare monitoring: The need to control influential factors
FL06 Kinjal Bhatt - Lipid profiling of boar tainted and untainted pig plasma using GC×GC-TOFMS
2:10 - 2:30 PM FL07 Lina Mikaliunaite - Computational method for untargeted determination of cycling yeast metabolites using comprehensive two-dimensional gas chromatography time-offlight mass spectrometry
FL08 Wan Sin Heng - Rapid detection of bacteria in food using static-headspace comprehensive two-dimensional gas chromatography (HS-GC×GC)
2:30 - 2:50 PM FL09 Rushali Dargan - Using two-dimensional gas chromatography to understand decomposition odour in the Canadian environment
FL10 Sonia Schöneich - Tile-based fisher ratio analysis of comprehensive three-dimensional gas chromatography with mass spectrometry detection data
2:50 - 3:20 PM Coffee Break sponsored by JEOL
3:20 - 4:50 PM Guided Discussion 2: GC×GC, will it ever be in common use in the petroleum laboratories?
- Lenny Kouwenhoven, Jop Bezuijen, Christina Kelly, and Jon Sims
5:00 PM LECO Whiskey Tasting and Science Event
WEDNESDAY FEBRUARY 1, 2023
8:30 - 9:00 AM Registration
9:00 - 9:15 AM Opening Remarks
9:15 - 9:35 AM OL13 James Harynuk - Blueberries and wheat and beer, oh my! Adventures in the application of GC×GC to foodomics
9:35 - 9:55 AM OL14 Tatiana Cucu - Lager beer flavour profiling by stir bar sorptive extraction, GC×GC separation and time-of-flight mass spectrometry
9:55 - 10: 15 AM OL15 Andrea Schincaglia - Chromatographic fingerprint of Pistacia vera fruits: an aromatic tour around the world
10:15 - 10:35 AM FL11 Anika Lokker - Non-destructive identification of prehistoric adhesives by HS-GC×GC-TOFMS: Preliminary study
FL12 Micaela Galletta - Untargeted characterization of the volatile fraction and targeted determination of chiral lactones in Marsala wines by means of flow-modulation headspace SPME-chiralGC×polarGC-ToFMS
10:35 - 11:05 AM Coffee Break sponsored by Merck
11:05 - 11:25 AM OL16 Mariosimone Zoccali - Determination of xenobiotics in food samples through reduced sample preparation coupled to cryogenic-modulation GC×GC combined with triplequadrupole mass spectrometry
11:25 - 11:45 AM OL17 Thomas Gröger - The use of comprehensive twodimensional gas chromatography for pharmaceutical applications: Investigation of complex drugs
11:45 - 12:05 PM OL18 Marco Beccaria - Two-dimensional gas chromatography-based techniques for lipidomics investigations
12:05 - 12:25 PM OL19 Flavio A Franchina - Method development and optimization for monitoring probe exhaled breath metabolites using parallel MS-based analytical platforms
12:25 - 1:30 PM Lunch
1:00 - 1:20 PM OL20 Caroline Gauchotte-Lindsay - Novel pipeline for elucidation of high-level chemical mechanisms using nontargeted analysis by comprehensive two-dimensional gas chromatography coupled with mass spectrometry
1:20 - 1:40 PM OL21 Steven Mascrez - Bursting the chromatographic fingerprint by combining vacuum-assisted headspace, multicumulative trapping SPME, and GC×GC
1:40 - 2:00 PM OL22 Joe Binkley - Application of a unique dual detection GC×GC-TOFMS/FID setup for reliable qualitative and quantitative fragrance analysis
2:40 - 3:10 PM OL23 Damien Eggermont - Exploring the cup of coffee using GC×GC-MS combined with multiple combination of headspace extractions
3:10 - 4:30 PM Closing and Awards
POSTER LIST MDCW 2023