ASMS: Bruker Applied Breakfast Workshops
Applied Breakfast Workshops at ASMS 2024
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Innovative Chromatography-Free Analytical Techniques for Advanced Polymer Characterization and Manufacturing Optimization
- Monday, June 3, 2024, 7:00 am - 8:00 am PST
- Anaheim Convention Center, 800 W Katella Ave, Anaheim, CA, USA
- Room: 210D
Mass spectrometry (MS) plays a crucial role in polymer analysis, enabling comprehensive assessment of structure, composition, additives, and molecular weight distribution. However, traditional MS methods often necessitate chromatography for sample separation. This workshop focuses on the streamlined various Chromatography FREE approaches including DART, which analyzes complex polymeric materials without prior preparation, utilizing hot metastable He atoms to induce thermal desorption and degradation, followed by ionization for analysis of stable materials. Case studies involving automotive tires and macro-/nano-plastics from Northeast Ohio illustrate the efficacy of DART-MS. Additionally, MALDI-MS, another chromatography-free MS method, is discussed for addressing performance issues in complex polyolefin-based materials, offering insights into reaction mechanisms and architectural distributions crucial for process optimization in manufacturing.
Workshop Agenda
7:00 am Introduction
- Kushal Modi, Business Development Manager, Bruker Scientific LLC, Billerica, MA, USA
7:10 am Direct Analysis in Real Time Mass Spectrometry (DART-MS) of Complex Polymer Systems
- Chrys Wesdemiotis, PhD, Professor at the University of Akron, Ohio
7:35 am New Approaches for Examining Complex Polyolefin Mixtures
- Tony Gies, PhD, Research Chemist, Dow
8:00 am Q & A with the Speakers
8:10 am Close of Breakfast Workshop
Solving the PFAS challenge: novel targeted and non-targeted workflows on triple quads and ion mobility HRMS
- Tuesday, June 4, 2024, 7:00 am PST
- Anaheim Convention Center, 800 W Katella Ave, Anaheim, CA, USA
- Room: 210D
PFAS, persistent chemicals used in consumer products since the 1940s, pose significant risks to both humans and the environment due to their persistent, bio-accumulative, and toxic properties. EPA regulations exist to monitor selected PFAS compounds, but the estimated total of 15,000 PFAS compounds, complicates comprehensive analysis. Two workflows are presented: targeted analysis using a highly sensitive triple quadrupole for routine monitoring, exceeding EPA regulations, and a non-targeted approach combining trapped ion mobility spectrometry (TIMS) with UHPLC-HRMS for broader PFAS detection and annotation of unknown PFAS using smart software tools. These methods aim to improve detection capabilities and understanding of PFAS exposure for better public health and environmental protection.
Workshop Agenda
7:00 am Introduction
- Bob Galvin, PhD, VP Marketing
7:10 am Comprehensive PFAS Screening of 5,000 Suspects with the timsTOF
- Arnd Ingendoh, PhD, VP Business Development, Bruker Applied Mass Spectrometry, Germany
7:35 am Targeted PFAS Screen & Quantitate To Maxime Utilization of EPA Method 1633 on the EVOQ DART-TQ+ System
- Chris Elicone, Global Product Marketing Manager, Bruker Applied Mass Spectrometry, USA
8:00 am Q & A with the Speakers
8:10 am Close of Breakfast Workshop
Rapid and Dynamic Quantitative Screening of Synthetic Cannabinoids with DART-MS Analysis: A Collaborative Case Study
- Wednesday, June 5, 2024, 7:00 am PST
- Anaheim Convention Center, 800 W Katella Ave, Anaheim, CA, USA
- Room: 210D
Join us for a presentation of a novel rapid and quantitative screening approach for detection and measurement of 16 synthetic cannabinoids using DART-MS. Our novel approach resolves drawbacks associated with traditional immunoassay-based detection, such as cross-reactivity and low sensitivity. Through comparative validation with LC-MS using confirmed positive urine samples, the DART-MS screening method demonstrates high selectivity and accuracy. With a throughput of under 30 seconds per sample, this approach offers a cost-effective and efficient solution for detecting synthetic cannabinoids in urine samples.
Workshop Agenda
7:00 am Introduction
- Terry Bates, Application Specialist, Bruker Applied Mass Spectrometry, MA, USA
7:10 am The Search for a Rapid Screening Approach for Synthetic Cannabinoids
- Alex Maggitti, Sr. Clinical Development Scientist, DrugScan Inc, PA, USA
7:20 am Direct Analysis in Real Time- Mass Spectrometry (DART-MS): The Fundamentals
- Terry Bates, Application Specialist, Bruker Applied Mass Spectrometry, MA, USA
7:35 am The Case for DART-MS Analysis: A Financial Perspective
- Lauren Ritter, Director, Laboratory Operations, DrugScan, PA, USA
7:45 am Method Development and Cross Correlation Study of DART-MS for Quantitative Screening
- Alex Maggitti, Senior Clinical Development Scientist, DrugScan Inc, Pennsylvania, USA
- Terry Bates, Application Specialist, Bruker Applied Mass Spectrometry, MA, USA
8:00 am Q&A with the speakers
8:10 am Close of Breakfast Workshop
