ASMS: Agilent Ion Mobility user meeting
Superior measurement with IM/Q-TOF
Join thought leaders and your Agilent team of experts in our Ion Mobility user meeting as we explore the use of powerful proven and innovative capabilities of ion mobility (IM).
We are excited to share what has been achieved within Agilent, and more importantly in the IM community. This year we are pleased to showcase new research using electron capture detection (ECD). Many groups have written software benefiting the entire IM community, and we will present highlights. For example, the PNNL pre-processor continues to be a powerful software enabling multiple workflows from high-resolution demultiplexing to DIA->DDA conversion. This allows for the identification of IM separated compounds such as PFAS using FluoroMatch, or lipids using Lipidmatch, and enables the analysis of oligonucleotides and identification of proteins.
Here are the topics discussed:
Talk 1: Intro to Agilent Ion Mobility
- Christian Klein, Agilent
Talk 2: Tracing the biological fate of PFASs in living organisms and in-vitro systems using high-resolution mass spectrometry and ion mobility
- Carrie McDonough, Carnegie Mellon University
Talk 3: Oligonucleotide sequencing using ion mobility spectrometry-mass spectrometry with a Bioconfirm based workflow
- Jack Ryan, University of North Carolina at Chapel Hill
Talk 4: Untangling the compositional complexity of oligonucleotide therapeutics for advancing drug development
- Jace W. Jones, University of Maryland
Talk 5:** Intact protein quantitation – using iFAMS Quant+: Gabor-transform software for automated biomolecular mass spectrometry signal deconvolution and quantitation**
- Jim Prell, University of Oregon
Talk 6: Oh, the databases you’ll build
- Guozhi Zhang, University of North Carolina at Chapel Hill
Talk 7: Automated 96-well desalting and collision induced unfolding analysis of biotherapeutics
- Michael Armbruster, University of Michigan
Talk 8: Real-time automation of high-speed microdroplet reactions to enhance throughput in characterizing therapeutic proteins
- Krishna Anapindi, Gilead Sciences
Talk 9: Digital quadrupole isolation and electron capture dissociation provide structure information on native protein complexes
- Carter Lantz, Texas A&M University
Talk 10: Implementation of native RapidFire ion mobility mass spectrometry (nRF-IM-MS) for the assessment of the higher order structure (HOS) stability of biotherapeutics
- Mack Shih, FDA
Talk 11: Advancing antibody epitope mapping and isoaspartic acid detection: Insights from HDx and electron-based fragmentation techniques
- Blaine Roberts, Emory University
