Exploring Advanced Detector Analytics with LNPs
The future of medicine is at our doorstep, driven by the revolutionary potential of Lipid Nanoparticles (LNPs) in drug and vaccine delivery. As we stand on the brink of groundbreaking advancements, it is crucial to focus on the need for high-quality production processes and cutting-edge analytics to ensure the efficacy and safety of these innovations.
Join us for an insightful exploration of how advanced detector analytics are shaping the future of pharmaceuticals and paving the way for next-generation therapies. Together, let's unlock the full potential of LNPs and transform the landscape of modern medicine.
With the field’s substantial progress, we are delighted to bring German, Swiss and Austrian experts together.
This industry-academic meeting aims to discuss:
- Accelerating Development & Innovations – High Throughput and automated screening approaches
- Advancing Next-Generation RNA analytics –Looking into analytical toolbox in monitoring multi Critical Quality Attributes in mRNA LNP processes
- Capturing of LNP critical quality attributes by SEC/FFF-MALS
- Enhanced LNP characterization by DLS, PALS, and real-time MALS
- Round-table discussions and individual consultations with Waters | Wyatt Technology scientists
- Workshop: LNP characterization with light scattering
- Techniques: DLS, FFF-MALS, PALS, RT-MALS, SEC-MALS
Who should join? Scientists working Lipid Nanoparticles in:
- Academia
- Discovery
- Formulation
- Process development
- Quality control
- Scale up manufacturing departments
- Active users of Wyatt light scattering instruments
- Anyone interested learning more about light scattering and its applications to lipid nanoparticles
Registration
The meeting is free of charge. Registration is required.
Program
08:30 Registration, Tea and Coffee
09:00 Welcome and Introduction
- Dr. Felix Deluweit, Sr. Account Manager (Waters GmbH / Wyatt Technology)
09:15 High throughput and online characterization of LNP by DLS, PALS and RT-MALS
- Dr. Felix Deluweit, Sr. Account Manager (Waters GmbH / Wyatt Technology)
09:45 An mRNA-LNP Vaccine Platform Tailoring the Immunogenicity Profile from Prophylactic to Therapeutic Applications, Reducing Reactogenicity and Extending Shelf-Life Stability
- Dr. Roland Böttger, Sr Research Scientist (CureVac)
10:15 Nanoformulations, the story from microfluidic screening to continuous manufacturing
- Mrs. Eilien Heinrich, PostDoc (Nanomaterials for Cancer Therapy - Fraunhofer Institute for Microengineering and Microsystems IMM)
10:45 Coffee break
11:15 Production of Lipid Nanoparticles Using Impingement Jets Mixing
- Dr.-Ing. Matthias Luebbert, Principal Process Engineer (Knauer)
11:45 Deciphering Messages Packed in Fat - LC/MS for Lipid Impurities and RNA Sequence
- Dr. Sascha Schiffrin, Principal Pharma Sales Development Specialist (Waters GmbH)
12:15 Lunch break
13:15 Guest Talk - TBA
13:45 Comparison of MS-based sequencing methods for CRISPR single guide RNA
- Dr. Michael Rühl, Senior QC researcher (BioSpring GmbH)
14:15 Deformulating Size Exclusion Chromatography for LNP Payload Quantitation
- Dr. Michael Kudlich, Sr Chemistry Sales Development Specialist (Waters GmbH)
14:45 Coffee break
15:15 Round-Table discussion with experts from Wyatt and Waters Corporation
16:15 End of Seminar
