Mega Molecules in Biopharmaceuticals - Milford, MA

Mega molecules, also known as biopharmaceuticals or biologics, are large, complex therapeutic compounds that revolutionize medicine. They're significantly larger than traditional small-molecule drugs and are often produced in living organisms. These include everything from antibodies (IgG and IgM) to gene therapies with heterogenous delivery vehicles and payloads like lipid nanoparticles and circular DNA.

The unique size and complexity of these molecules present significant analytical challenges. To overcome these hurdles, a new generation of bio-tools is needed for a deeper understanding of their biochemical and biophysical interactions.  

Register HERE

🗓️ Date: November 18, 2025
🕗 Time: 10:00 AM–4:00 PM
📍 Location: Waters Corporation, 34 Maple Street, Milford, MA 01757

Solutions from Waters

Waters provides a suite of advanced analytical platforms to help you characterize mega molecules and streamline your biopharmaceutical development. Our solutions are designed to address key challenges in manufacturing, quality control, and regulatory compliance.

Featured Analytical Platforms:

• Charge Detection Mass Spectrometry (CD-MS): This powerful tool is ideal for characterizing mega-mass biomolecules, including capsid ratios and DNA packaging, with high-resolution native analysis.
• Liquid Chromatography-Mass Spectrometry (LC-MS): Use LC-MS to quantify impurities, characterize proteins and mRNA, and enable rapid spent media analysis to optimize feed strategies. You can also gain confidence in your oligonucleotide mapping with our high-resolution mass spectrometers with new features including MS2 with the new RNA 3.0 software.

Key Benefits

For Biologists & Process Development:

• Deeper Insights: Gain a better understanding of product heterogeneity and its biological implications.
• Early Characterization: Assess quality attributes early in development to inform clone selection and reduce risks.
• Process Optimization: Use spent media analysis to optimize media composition and employ high-throughput screening (HTS) and design of experiments (DoE) for efficient studies.
• Risk Assessment: Obtain analytical data to evaluate antigen specificity, potency, and potential immunogenicity risks.

For Analytical Development Scientists:

• Comprehensive Evaluation: Get a complete picture of molecular weight, structure, post-translational modifications (PTMs), impurities, and degradation.
• Impurity Identification: Accurately identify and quantify both product- and process-related impurities. 

Join Us to Learn More

Discover how Waters' advanced liquid chromatography, mass spectrometry, light scattering, and particle analysis solutions can help you revolutionize biopharmaceuticals.