Associate Director Formulation Sciences, TTD, Oncology R&D

AstraZeneca. We are a global, science-led, patient-focused pharmaceutical company. We are dedicated to transforming the future of healthcare by unlocking the power of what science can do for people, society and the planet.

Our TTD-Chemistry site situated in Whitechapel, London is one of over 400 sites here at AstraZeneca, providing an environment where everyone feels comfortable and able to be themselves is at the core of AstraZeneca’s priorities, it’s important to us that you bring your full self to work every day. To help you maintain your best self, here’s a sneak peek into some of the things this site provides for you After-work events, Lunch & Learns, spacious balanced office working environment. Situated in the heart of London’s historical east end close to the fashionable areas of Shoreditch, Spitalfields and Brick Lane with excellent public transport links to central London.

In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office.

At AstraZeneca's Oncology R&D department, we push the boundaries of science to change the practice of medicine and transform the lives of patients living with cancer. We are a science-based, leading and significant Oncology enterprise united in our vision to eliminate cancer as a cause of death. With one of the broadest and deepest Oncology pipelines in the industry, there are many opportunities to work with new and novel drugs and help discover what's next.

ASSOCIATE DIRECTOR FORMULATION SCIENCES, TTD, ONCOLOGY R&D

Are you ready to make a difference in the world of Oncology?

We are seeking an Associate Director for our Formulation Sciences team in the TTD chemistry-London group. This role is pivotal in delivering on Formulation strategies for targeted therapeutics, including antibody drug conjugates (ADCs).

You will work closely with scientists from other subject areas including Chemistry, Bioconjugation, Bioscience team, Bioanalysis, ADME/DMPK, Safety Sciences and development as part of the wider drug discovery project team and present your work regularly to peers and senior partners.

What you’ll do

As an Associate Director, you will devise and execute formulation strategies, lead the review, approval and interpretation of data, develop and optimize assays and formulation combinations, identify gaps in internal formulation technological capabilities, foster interdisciplinary teamwork, ensure work is performed in accordance with appropriate Safety, Health & Environment (SHE), quality and compliance standards, perform other duties in line with the role, and manage and mentor a team of scientists.

Essential for the role

• Doctoral degree (Ph.D.) in Chemistry, Biochemistry, Pharmaceutical Sciences, or other relevant fields.

• Relevant degree and or biotech/pharmaceutical industry experience, with a strong track record of scientific innovation and success in advancing candidates through milestones.

• Subject Matter Expert (SME) in biophysical characterization of large molecules and related techniques.

• Substantial experience with assay design, optimization, and validation of stability assessments from colloidal and confirmational stability with respect to large molecules.

• Hands on experience with relevant instruments such as Dynamic Light Scattering (DLS), Differential Scanning Calorimetry (DSC), size-exclusion/hydrophobic interaction/ion exchange chromatography HPLC, cIEF, ceSDS, SEC-MALS, nephelometry, UV/Vis spectroscopy, and LCMS.

• In-depth knowledge of the drug R&D process and demonstration of characterization related activities to achieve project milestones.

• Track record of effective line management and talent development.

• Track record of scientific innovation as evidenced by scientific publications, patents, and oral presentations at conferences.

• Strong oral and written communication skills, team-working and time-management skills.

• Beneficial to have high throughput experience with formulation screening

• Beneficial to have the deep knowledge of ADC conjugation chemistries (mAbs, linkers and payloads) and a broad range of analytical methods related to characterization.

Why AstraZeneca?

• We foster a mindset of courage, where everyone is empowered to step up, innovate and work at pace. Our pipeline is a testament to our growth, both now and in the future.

So, what’s next?

• Ready to join us in our mission to eliminate cancer as a cause of death? Apply now!

• Competitive salary package and benefits

• Close Date: 24/05/2024