Postgraduate in Mass Spectrometry

Novartis is an innovative medicines company. Every day, we work to reimagine medicine to improve and extend people’s lives so that patients, healthcare professionals and societies are empowered in the face of serious disease. Our medicines reach more than 250 million people worldwide.

POSTGRADUATE IN MASS SPECTROMETRY

We are looking for a Postgraduate to join the Analytical Characterization (AC) team in Basel, Switzerland, within the Novartis Technical Research and Development (TRD) Biologics Analytical Development unit. The successful applicant will be part of the mass spectrometry group working in a highly collaborative and scientific environment focusing on the characterization of novel biologics entities.

About the Role

• Preferred start date 1st of July 2024 onwards

• Duration: Initial contract up to two years

Your responsibilities

• Provide support to the development of therapeutic protein characterization methods by liquid chromatography coupled to mass spectrometry (LC-MS) based workflows.

• Implementation of (semi-) quantitative methods for the monitoring and reporting of targeted product quality attributes as well as new peaks of therapeutic proteins using state-of-the-art LC-MS equipment and software, by e.g. multi-attribute method (MAM) or targeted LC-MS assay.

• Plan and perform automated protein enzymatic digestion on a robotic system.

• Perform project-specific method qualification and assessment of method robustness, where applicable.

• Documentation of experiments and results in electronic systems.

What you’ll bring to the role

• Education: MSc in Biotechnology, Biochemistry, Analytical Chemistry or related field. Relevant work experience would be an asset.

• Languages: Strong communication skills in English; proficiency in German or French would be an asset.

• Experience/Professional requirements:

  • Strong hands-on experience in liquid chromatography (HPLC and UHPLC e.g. Vanquish™)

  • Hands-on experience in protein sample preparation and analysis (e.g. peptide mapping by LC-MS) preferably using automated sample preparation on a robotic system (e.g. Hamilton STARlet)

  • Strong theoretical knowledge of protein biochemistry and protein posttranslational modifications

  • Theoretical knowledge and previous experience working with mass spectrometers (e.g. Orbitrap and Q-ToF analyzers)

  • Experience desired with selected reaction monitoring (SRM), parallel reaction monitoring (PRM), selected ion monitoring (SIM), or new peak detection (NPD)

  • Experience with Chromeleon and/or Genedata Expressionist would be an asset

Please submit a cover letter that includes your motivation for the position and from when you will be available. Thank you.

Commitment to Diversity and Inclusion

• Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve.

Accessibility and accommodation

• Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to [email protected], and let us know the nature of your request and your contact information. Please include the job requisition number in your message.