Principal Scientist Oligonucleotide Process Development (Billerica MA)
Our passion for science and technology is what drives our more than 64,000 employees across 66 countries to find solutions to some of today’s toughest challenges and create more sustainable ways to live.
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This role does not offer sponsorship for work authorization. External applicants must be eligible to work in the US.
Principal Scientist Oligonucleotide Process Development (Billerica MA)
Lead process development and synthesis strategies of ASOs, siRNAs and other synthetic modalities. (100 mg-5 g scale). Identify process improvements for better yield, purity, turnaround times and lower cost of goods
Experience with a variety of Oligonucleotide modalities (siRNAs, ASOs) and producing Lipids, Dyes, peptides and antibody conjugates.
Strong laboratory skills in synthesis, purification, and characterization of Antibody-Oligo conjugate are preferred.
Ability to analyze, interpret, and present data are a prerequisite current with scientific literature and understanding of the state of the art in oligonucleotide chemistry, purification, and screening strategies. Expertise in state-of-the-art analytical techniques such as UPLC, HPLC, LC-MS and NMR.
Work with both internal chemistry team and external CRO’s to generate innovative solutions to synthetic and drug design challenges within the context of oligonucleotide drug discovery projects.
Experience with DoE and QbD (Quality by design principles).
Track progress against project timelines, generate regular status updates, and communicate progress and issues to management.
Who You Are
Minimum Qualifications:
PhD in Oligonucleotide Chemistry and relevant experience in a drug discovery/Process development environment with at least 8 years of oligonucleotide synthesis experience in industry.
Preferred Qualifications:
- Hand on experience on Akta Synth and OP-100 to modify the protocols and strong familiarity with Unicorn software.
- Excellent project/time management, and problem-solving skills.
- Strong communication and people skills and the ability to thrive in a team and goal driven environment
- Proven track record of scientific contributions in oligonucleotide and conjugates research as evidenced by publications/presentations/patent applications and/or the identification of preclinical development candidates.
Location: Billerica MA
Pay Range for this position: $129,000 - $193,400
The offer range represents the anticipated low and high end of the base pay compensation for this position. The actual compensation offered will be determined by factors such as location, level of experience, education, skills, and other job-related factors. Position may be eligible for sales or performance-based bonuses. Benefits offered by the Company include health insurance, paid time off (PTO), retirement contributions, and other perquisites. For more information click here.
What we offer:
We are curious minds that come from a broad range of backgrounds, perspectives, and life experiences. We believe that this variety drives excellence and innovation, strengthening our ability to lead in science and technology. We are committed to creating access and opportunities for all to develop and grow at your own pace. Join us in building a culture of inclusion and belonging that impacts millions and empowers everyone to work their magic and champion human progress!
Apply now and become a part of a team that is dedicated to Sparking Discovery and Elevating Humanity!
