Principal Scientist II - Discover Sciences (Dsc)

Novartis is an innovative medicines company. Every day, we work to reimagine medicine to improve and extend people’s lives so that patients, healthcare professionals and societies are empowered in the face of serious disease. Our medicines reach more than 250 million people worldwide.

At Novartis, we are reimagining medicine to improve and extend people's lives. We use innovative science and technology to address some of society's most challenging healthcare issues. We discover and develop breakthrough treatments and find new ways to deliver them to as many people as possible. In 2021, we touched 766 million patients with our products. How can we continue to advance our science to help even more patients in need? We believe the answers are found when curious, courageous, and collaborative people are empowered to ask new questions, make bolder decisions, and take smarter risks.

PRINCIPAL SCIENTIST II - DISCOVER SCIENCES (DSC)

In Discover Sciences (DSc) at BioMedical Research (BR), we are at the core of Novartis’ purpose, applying all technologies and modalities towards novel drug discovery in partnership with our Disease Area collaborators to find new therapies for patients. We are looking for a highly motivated, passionate researcher with a strong scientific background in chemistry, biology or related life science disciplines, a curious mind-set, and cultural agility to lead and coordinate all aspects of project management for in vitro activity assays and biophysics along with compound management as it relates to lead optimization workflows in a highly collaborative environment. Join us and help reimagine medicine!

Your responsibilities:

• Serve as the BR India Lead for the Discovery Sciences (DSc) Lead Identification and Optimization (LIDO) group interfacing with the global DSc LIDO community as member of the newly forming BR India group.

• Co-lead multidisciplinary project teams with a focus on in vitro activity assay development and implementation for biochemical, cell-based and biophysics assays as well as compound management in a highly collaborative environment with colleagues in DSc US/Switzerland and Indian CROs, to discover and develop novel therapies for high unmet medical needs.

• Manage transfer and troubleshooting of all assay protocols between Novartis project and compound management teams and the CRO.

• As a primary contact to the CRO, implement best practices for CRO assay management and ensure productivity, efficiency and project priority alignmentain in coordination with BR project teams.

• As a primary contact to the CRO, implement best practices for CRO assay management and ensure productivity, efficiency and project priority alignment.

• Work in close collaboration with multiple NVS line functions to enable project success through state-of-the-art drug discovery approaches.

• Implement high-level assay protocols at CRO adapted from internal Novartis SOPs or literature.

• Ensure timely data reporting into NVS databases and act as main point of contact to help identify/troubleshoot any challenges that arise affecting assay performance, compound management, quality or timelines.

• Coordinate Protein and Structure workflows.

• Act as an ambassador of BR to external groups and develop new relationships.

Diversity & Inclusion / EEO

We are committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.

Role Requirements:

What you will bring to the role

• PhD degree in chemistry, biology or related life science discipline with profound understanding of all types of in vitro assay development and execution with at least 7+ years of drug discovery experience in a Biomedical or pharmaceutical research setting.

• Significant CRO- and project leadership experience and a track-record of impact on multiple projects, from hit generation to development candidate selection.

• Proven scientific and technical background in drug discovery, with demonstrated proficiency in assay development, optimization, and screening of small molecules;

• Proven experience in the design and implementation of 384-well microplate assays for LMW compound / protein interactions using the most common biochemical and cell-based assay and detection technologies:

• (FI, FP, TR-FRET, luminescence, LC-MS, biophysical methods).

• (fluorescence and luminescence read-outs, RGA, GFP-tagged protein assays, imaging).

• Biophysics characterization methods (i.e. SPR, DSF).

• Experience with enzymology, kinetics and mode of action studies a plusmethods using established quality control metrics as well as proven experience in troubleshooting.

• Experience with enzymology, kinetics and mode of action studies a plus.

• A mind-set of curiosity and openness to diverse thinking, with an enthusiasm to develop yourself and others.

• Strong understanding and adherence to Novartis established health, safety and environmental policieso present and discuss project strategies and challenges in a proactive manner in coordination with all other project managers for various functions critical to integrated outsourcing project success.

• Strong understanding and adherence to Novartis established health, safety and environmental policie.

• Aptitude to work in a fast-paced team-oriented matrix environment with flexibility to adapt to rapidly changing priorities and deadlines.

Why Novartis?

769 million lives were touched by Novartis medicines in 2020, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives.
We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.
We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying! Imagine what you could do here at Novartis!

Join our Novartis Network:

Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network