Senior Lipid Synthesis Chemist (NMR, LS-MS, HPLC, ELSD, CAD)

Our passion for science and technology is what drives our more than 64,000 employees across 66 countries to find solutions to some of today’s toughest challenges and create more sustainable ways to live.

We are here for people at every step, helping create, improve and prolong life. We deliver personalized treatments for serious diseases and enable people to achieve their dream of becoming parents. We empower the scientific community. Our tools, services, and digital platform make research simpler, more exact, and help to deliver breakthroughs more quickly. We provide progressive treatment solutions that help improve access to health thanks to the accuracy of our tests and the reliability of our medicine. As a company, we are at the forefront of digital living. Our science sits inside technologies that change the way we access, store, process, and display information. Our innovative technology drives human progress and opens new possibilities to transform life on Earth as we know it.

Thanks to the constant curiosity of our employees, we are making discoveries that can change the landscape of entire industries. For more than 350 years, we’ve been pushing the boundaries of what’s possible, and we’ll continue to do so in the years to come.

SENIOR LIPID SYNTHESIS CHEMIST

Work Your Magic with us! Start your next chapter and join MilliporeSigma.

Ready to explore, break barriers, and discover more? We know you’ve got big plans – so do we! Our colleagues across the globe love innovating with science and technology to enrich people’s lives with our solutions in Healthcare, Life Science, and Electronics. Together, we dream big and are passionate about caring for our rich mix of people, customers, patients, and planet. That's why we are always looking for curious minds that see themselves imagining the unimaginable with us.

This role does not offer sponsorship for work authorization. External applicants must be eligible to work in the US.

Your Role:

• The Senior Lipid Synthesis Chemist at MilliporeSigma is a member of the targeted mRNA delivery group and will work on crafting a groundbreaking platform which will enable the therapeutic delivery of mRNA with high precision and safety.

• Targeted mRNA delivery has the potential to change patient lives by enabling life changing therapies.

• An M-Ventures funded biotech start-up is poised to seize the opportunity at the intersection between our Healthcare and Life Science Divisions.

• Our mandate is to think big and reach across teams to leverage the full capabilities of the organization.

• With the agility of a startup and the resources of a leading multinational organization, the targeted mRNA delivery team is transforming the way researchers develop mRNA therapies.

Responsibilities include:

• Design of novel ionizable lipids, including cationic and anionic lipids, to deliver novel nucleic acid cargo to desired organ of interest

• Designing novel shorter routes of synthesis to enable faster turnaround and higher yield

• Synthesis and analysis of novel lipids

• Active engagement with formulations and biology team to develop structure activity relationship (SAR) based-designs

• Present study observations and data in cross-functional project meetings

• Actively engage with legal/IP teams to determine patentability and freedom to operate on novel designs and enable the team to generate crucial intellectual property

• The lab is located in Burlington, MA with a satellite location in Billerica, MA

Who You Are:

Minimum Qualifications:

• PhD in Organic Chemistry, or other life science and 3+ years of experience in an academic or industrial setting

Preferred Qualifications:

• Excellent track record of recent, active hands-on lab work involving organic synthesis

• Experience with lipid synthesis

• Experience with flow chemistry

• Experience in NMR, LS-MS, HPLC, ELSD, CAD and varied purification strategies

• Familiar with Pharma or Biopharmaceutical industry, especially drug discovery

• Excellent verbal and written communication skills in English

• Work experience in a non-viral delivery group

• Ability to work under pressure in a global, matrixed organization across multiple time zones and geographies

• Highly organized, detailed, creative, results-driven problem solver with demonstrated flexibility and collaborative working style

What we offer:

• We are curious minds that come from a broad range of backgrounds, perspectives, and life experiences.

• We celebrate all dimensions of diversity and believe that it drives excellence and innovation, strengthening our ability to lead in science and technology.

• We are committed to creating access and opportunities for all to develop and grow at your own pace.

• Join us in building a culture of inclusion and belonging that impacts millions and empowers everyone to work their magic and champion human progress!

Apply now and become a part of our diverse team!

If you would like to know more about what diversity, equity, and inclusion means to us, please visit

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