Applications from the field of Pharma & Biopharma focused on LC/Orbitrap - page 3

High-sensitive multi-attribute analysis of ADCs under native conditions by using an online multiple heart-cut 2D-LC-HRAM mass spectrometry system

Posters

| 2025 | Thermo Fisher Scientific (HPLC Symposium)

2D-LC, LC/MS, LC/MS/MS, LC/Orbitrap, LC/HRMS, GPC/SEC

Instrumentation

2D-LC, LC/MS, LC/MS/MS, LC/Orbitrap, LC/HRMS, GPC/SEC

Manufacturer

Thermo Fisher Scientific

Industries

Pharma & Biopharma

Green ion pair and HFIP free method for ASO RNA analysis with GLP compliant automated data handling

Posters

| 2025 | Thermo Fisher Scientific (HPLC Symposium)

LC/MS, LC/MS/MS, LC/Orbitrap, LC/HRMS

Instrumentation

LC/MS, LC/MS/MS, LC/Orbitrap, LC/HRMS

Manufacturer

Thermo Fisher Scientific

Industries

Pharma & Biopharma

Detailed study into ASO impurity analysis, lessons learned, and myths dispelled while moving to compliant platform methods

Posters

| 2025 | Thermo Fisher Scientific (HPLC Symposium)

LC/MS, LC/MS/MS, LC/Orbitrap, LC/HRMS

Instrumentation

LC/MS, LC/MS/MS, LC/Orbitrap, LC/HRMS

Manufacturer

Thermo Fisher Scientific

Industries

Pharma & Biopharma

Confident and sensitive identification of semaglutide degradation products and impurities using a UHPLC-HRAM MS platform

Applications

| 2025 | Thermo Fisher Scientific

LC/MS, LC/MS/MS, Software, LC/Orbitrap, LC/HRMS

Instrumentation

LC/MS, LC/MS/MS, Software, LC/Orbitrap, LC/HRMS

Manufacturer

Thermo Fisher Scientific

Industries

Pharma & Biopharma

Liquid chromatography – high-resolution mass spectrometry method for determination of NDSRI in six beta-blocker drug substances

Applications

| 2025 | Thermo Fisher Scientific

LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap

Instrumentation

LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap

Manufacturer

Thermo Fisher Scientific

Industries

Pharma & Biopharma

Increased sensitivity and throughput for native intact mass analysis using a NativePac OBE-1 SEC column and an Orbitrap Ascend Tribrid mass spectrometer

Technical notes

| 2024 | Thermo Fisher Scientific

LC/HRMS, LC/MS, LC columns, LC/Orbitrap, LC/MS/MS, Consumables

Instrumentation

LC/HRMS, LC/MS, LC columns, LC/Orbitrap, LC/MS/MS, Consumables

Manufacturer

Thermo Fisher Scientific

Industries

Pharma & Biopharma

Performance comparison of reversed-phase C18 columns for peptide mapping of monoclonal antibodies

Applications

| 2024 | Thermo Fisher Scientific

Consumables, LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap, LC columns

Instrumentation

Consumables, LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap, LC columns

Manufacturer

Thermo Fisher Scientific

Industries

Pharma & Biopharma, Proteomics

Nano and Microscale Peptide Mapping by LC-UV-Orbitrap-Astral Detection of Monoclonal Antibodies with Fraction Collection for Detailed Analysis

Posters

| 2024 | Thermo Fisher Scientific (ASMS)

HPLC, LC/MS, LC/HRMS, LC/MS/MS, LC/Orbitrap

Instrumentation

HPLC, LC/MS, LC/HRMS, LC/MS/MS, LC/Orbitrap

Manufacturer

Thermo Fisher Scientific

Industries

Pharma & Biopharma

Confident transformation site localization of PROTAC drug metabolites facilitated by multi-stage fragmentation LC-HRAM-MS

Posters

| 2024 | Thermo Fisher Scientific (ASMS)

LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap

Instrumentation

LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap

Manufacturer

Thermo Fisher Scientific

Industries

Pharma & Biopharma

Applying UHPLC HRAM MS-MS/MS method to assess host cell protein clearance during the purification process development of therapeutic mAbs

Posters

| 2024 | Thermo Fisher Scientific (ASMS)

LC/MS, LC/MS/MS, LC/HRMS, LC/Orbitrap

Instrumentation

LC/MS, LC/MS/MS, LC/HRMS, LC/Orbitrap

Manufacturer

Thermo Fisher Scientific

Industries

Pharma & Biopharma, Proteomics