Applications from the field of Pharma & Biopharma focused on LC/Orbitrap - page 5

Accurate and consistent analysis of poly(A) tails of mRNA therapeutics on a UHPLC-HRAM-MS platform

Applications

| 2024 | Thermo Fisher Scientific

LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap

Instrumentation

LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap

Manufacturer

Thermo Fisher Scientific

Industries

Pharma & Biopharma

Increased sensitivity and throughput for native intact mass analysis using a NativePac OBE-1 SEC column and an Orbitrap Ascend Tribrid mass spectrometer

Technical notes

| 2024 | Thermo Fisher Scientific

LC/HRMS, LC/MS, LC columns, LC/Orbitrap, LC/MS/MS, Consumables

Instrumentation

LC/HRMS, LC/MS, LC columns, LC/Orbitrap, LC/MS/MS, Consumables

Manufacturer

Thermo Fisher Scientific

Industries

Pharma & Biopharma

Detection and identification of isotope-labeled glutathionetrapped reactive drug metabolites

Technical notes

| 2024 | Thermo Fisher Scientific

LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap, Software

Instrumentation

LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap, Software

Manufacturer

Thermo Fisher Scientific

Industries

Pharma & Biopharma, Clinical Research

LC/UV/HRAM MS-based impurity profiling and structure elucidation of phosphoramidite raw materials used for oligonucleotide synthesis

Applications

| 2023 | Thermo Fisher Scientific

Software, LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap

Instrumentation

Software, LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap

Manufacturer

Thermo Fisher Scientific

Industries

Pharma & Biopharma

Myth busting: “You cannot sequence oligonucleotides over 20 to 30 nucleotides long by LCMS/MS” Learn how to routinely sequence 100 nt oligonucleotides

Posters

| 2023 | Thermo Fisher Scientific (HPLC Symposium)

LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap

Instrumentation

LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap

Manufacturer

Thermo Fisher Scientific

Industries

Pharma & Biopharma

LC/UV/HRMS-based impurity profiling and structure elucidation of phosphoramidite raw materials used for oligonucleotide synthesis

Posters

| 2023 | Thermo Fisher Scientific (HPLC Symposium)

LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap

Instrumentation

LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap

Manufacturer

Thermo Fisher Scientific

Industries

Pharma & Biopharma

Analysis of genotoxic impurities in pharmaceuticals

Applications

| 2023 | Thermo Fisher Scientific

LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap

Instrumentation

LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap

Manufacturer

Thermo Fisher Scientific

Industries

Pharma & Biopharma

Characterization of adeno-associated viral proteins proteoforms using a top-down MS approach on a UHPLC-Orbitrap Ascend Tribrid mass spectrometer

Applications

| 2023 | Thermo Fisher Scientific

LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap

Instrumentation

LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap

Manufacturer

Thermo Fisher Scientific

Industries

Pharma & Biopharma, Proteomics

Sensitive quantitation of antisense oligonucleotides in plasma using high-resolution, accurate-mass (HRAM) mass spectrometry

Applications

| 2023 | Thermo Fisher Scientific

LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap

Instrumentation

LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap

Manufacturer

Thermo Fisher Scientific

Industries

Pharma & Biopharma

Highly sensitive and robust LC-HRAM-MS method for simultaneous quantitation of sixteen nitrosamines in multiple drug products

Applications

| 2023 | Thermo Fisher Scientific

LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap

Instrumentation

LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap

Manufacturer

Thermo Fisher Scientific

Industries

Pharma & Biopharma