Agilent InfinityLab LC Series - Site Preparation Checklist - SFC System

Significance of the Topic

The preparation of the laboratory site is critical to ensuring reliable and timely installation of the Agilent InfinityLab LC Series SFC System. Proper site preparation supports instrument longevity, consistent performance, and compliance with safety and environmental standards.

Objectives and Study Overview

This document provides a comprehensive checklist addressing space, utilities, environmental and supply requirements to facilitate smooth deployment of the SFC system. It aims to prevent installation delays, avoid additional costs, and ensure that users receive complete operational and safety guidance.

Methodology and Instrumentation

• 1260 Infinity II SFC Control Module (G4301A)
• 1260 Infinity II SFC Binary Pump (G4782A)
• 1260 Infinity II SFC Multisampler (G4767A)
• 1260 Infinity II Multicolumn Thermostat (G7116A)
• 1260 Infinity II Diode Array Detector WR (G7115A)
• 1260 Infinity II Multiple Wavelength Detector (G7165A)

The checklist covers required bench space, airflow clearances, electrical outlets, gas supply connections, and consumable provisions to support installation and routine operation.

Main Results and Discussion

• Dimensions and Weight: Each module’s footprint and weight specifications are detailed, including side and rear clearance for ventilation and connections. Bench load capacity must accommodate the complete system stack.
• Environmental Conditions: Modules require stable ambient temperatures (15–55 °C, depending on model) and controlled humidity levels (<80–95 %, non-condensing) for optimal functionality.
• Power Requirements: All modules operate on 100–240 VAC at 50/60 Hz, with maximum power consumption between 74 W and 180 W. Heat dissipation equals approximately 3.413 BTU/h per watt.
• Operating Supplies: Laboratories must supply high-purity CO₂ (99.99–99.9999 % depending on detector type), suitable solvents, tubing, Swagelok fittings, and waste collection materials.
• Gas and Exhaust Requirements: CO₂ inlet pressure must be regulated between 40 and 70 bar using lubricant-free valves. Exhaust venting of at least 1 L/min must be routed outside the lab via fume hood or dedicated line.
• Safety Features: Built-in pressure and temperature sensors, leak detection trays, automatic CO₂ shutoff valves, and software diagnostics safeguard against overpressure, temperature excursions, and fluid leaks.
• Installation Considerations: Recommended stacking configurations accommodate control module placement, maintain airflow, and support easy access. A PC with USB 2.0 port and Agilent OpenLAB CDS software support is required. Trained users should attend the installation to receive operational and safety training.

Benefits and Practical Applications

By adhering to this checklist, laboratories can achieve rapid system commissioning, minimize downtime, and maintain compliance with safety regulations. The guidelines ensure that the SFC system integrates seamlessly into workflows for high-throughput and high-precision chiral separations.

Future Trends and Opportunities

• Integration of remote monitoring and diagnostics to reduce on-site service visits.
• Development of more compact, energy-efficient CO₂ delivery and recycling systems.
• Advances in automation for sample handling, qualification (OQ/PQ), and maintenance tasks.
• Enhanced software analytics for predictive maintenance and instrument performance optimization.

Conclusion

Comprehensive site preparation is the foundation for successful installation and operation of the Agilent InfinityLab LC Series SFC System. Following this checklist mitigates risks, streamlines commissioning, and promotes reliable performance throughout the instrument’s lifecycle.

References

• No external references provided in source document.