Developing a Novel, Integrated LC-MS Workflow for High-resolution Monitoring and Characterization of Oligonucleotides
Applications | 2016 | WatersInstrumentation
HPLC, LC/TOF, LC/HRMS, LC/MS, LC/MS/MS
IndustriesProteomics
ManufacturerWaters
Key wordspromass, oligonucleotide, ost, uplc, oligonucleotides, polyt, acquity, masslynx, strand, ladder, waters, bio, note, mass, application, massprep, highresolution, class, workflow, tunable, profiling, using, separation, processed, sequencing, tuv, ultraviolet, monoisotopic, characterizing, adduct, system, resolution, biopharmaceutical, overhang, full, therapeutic, experimental, upper, masses, ssrna, target, high, figure, impurity, accuracy, hyperlink, review, min, tic, spectrometry
Similar PDF
APPLICATION SOLUTIONS FOR OLIGONUCLEOTIDES - APPLICATION NOTEBOOK
2017|Waters|Guides
[ APPLICATION NOTEBOOK ] APPLICATION SOLUTIONS FOR OLIGONUCLEOTIDES Table of Contents Introduction – UPLC Analysis of Synthetic Oligonucleotides......................................................................................................................... 4 [ HPLC & UPLC Separations ] Real-Time Analysis of RNAi Duplexes ....................................................................................................................................................................... 8 Semi-Preparative Scale Single-Stranded RNA Purification .......................................................................................................................... 11 Oligonucleotide…
Key words
oligonucleotides, oligonucleotidesuplc, uplcoligonucleotide, oligonucleotideacquity, acquityrnai, rnaiost, ostpromass, promassduplex, duplexduplexes, duplexeswaters, waterssirna, sirnaqda, qdaanalysis, analysisrna, rnaseparation
Evaluation of Alternative Ion-pairing Reagents in the Analysis of Oligonucleotides with the ACQUITY QDa Detector
2016|Waters|Applications
[ APPLICATION NOTE ] Evaluation of Alternative Ion-pairing Reagents in the Analysis of Oligonucleotides with the ACQUITY QDa Detector Robert E. Birdsall and Ying Qing Yu Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ Method compatibility with alternative Electrospray…
Key words
oligonucleotides, oligonucleotidesacquity, acquityqda, qdaoligonucleotide, oligonucleotidepairing, pairingalternative, alternativereagents, reagentshfip, hfipdibutylamine, dibutylaminebutylamine, butylaminepolyt, polytdetector, detectorost, ostevaluation, evaluationdegree
High-throughput Screening of Oligonucleotides for Identity and Purity Assessment Using the ACQUITY QDa Detector and ProMass for MassLynx
2016|Waters|Applications
High-throughput Screening of Oligonucleotides for Identity and Purity Assessment Using the ACQUITY QDa Detector and ProMass for MassLynx Robert E. Birdsall and Ying Qing Yu Waters Corporation, Milford, MA, USA A P P L I C AT I O N…
Key words
oligonucleotides, oligonucleotidespromass, promassqda, qdaacquity, acquitypurity, purityidentity, identitystrand, strandassessment, assessmentthroughput, throughputdata, datasynthetic, syntheticmass, massscreening, screeningmasslynx, masslynxacquired
ADDING COST EFFECTIVE MASS DETECTION FOR IMPROVED PRODUCTIVITY IN OLIGONUCLEOTIDE SCREENING ASSAYS
2016|Waters|Posters
ADDING COST EFFECTIVE MASS DETECTION FOR IMPROVED PRODUCTIVITY IN OLIGONUCLEOTIDE SCREENING ASSAYS Robert E. Birdsall, Sean M. McCarthy, Scott J. Berger, Maki Terasaki, Kenji Hiroseand Ying Qing Yu Biopharmaceutical Business Team, Waters Corporation, Milford, MA and Tokyo, Japan TUV Absorbance…
Key words
qda, qdapromass, promassacquity, acquityproductivity, productivitymass, massscreening, screeningoligonucleotides, oligonucleotidesspectrum, spectrumstraightforward, straightforwardassays, assaysdata, datathroughput, throughputcharge, chargestate, stateexpected