Andrew Alliance Pipette+ - Smarter, reproducible and traceable pipetting

Importance of the Topic

Pipetting is a fundamental operation in analytical and life science laboratories, where precision, reproducibility, and traceability directly influence data quality and experimental outcomes. Automated support for volume setting, protocol guidance, and real-time monitoring addresses common sources of error and enhances confidence in results.

Objectives and Overview

This application note presents Pipette+, the first fully integrated intelligent pipetting system developed in collaboration with Sartorius. The system combines Andrew Alliance electronic pipettes, a smart docking stand, and OneLab software to streamline protocol design, execution, and data logging in a few clicks.

Methodology and Instrumentation

The workflow relies on three key components:

• OneLab Software: Provides an intuitive graphical interface for creating, editing, and sharing executable pipetting protocols. Users receive step-by-step guidance and automatic setting of pipette parameters.
• Pipette+ Stand: A computerized docking station that communicates via Wi-Fi or Ethernet with OneLab and pairs with electronic pipettes over Bluetooth. It automatically identifies connected pipettes, confirms correct selection, sets parameters, monitors performance in real time, and charges devices.
• Andrew Alliance Electronic Pipettes: Single-channel (0.2 µL–10 mL) and multichannel (8- and 12-channel) models featuring automatic parameter adjustment, real-time usage feedback, and electronic tip ejection in a lightweight ergonomic design.

Main Results and Discussion

Implementation of the Pipette+ system delivers three primary advantages:

• Reproducibility: Automatic volume and parameter setting, correct pipette identification, and continuous monitoring reduce user-dependent variability.
• Productivity: Predefined protocols and guided workflows accelerate experiment setup, minimizing the need for repetition and freeing researchers to focus on data analysis.
• Traceability: Comprehensive logging of pipetting events and error notifications creates a complete audit trail to identify and address sources of deviation.

Benefits and Practical Applications

By integrating hardware and software, Pipette+ supports a wide range of laboratory applications including molecular biology assays, sample preparation for chromatography, and high-throughput screening. Key practical benefits include:

• Enhanced quality assurance and compliance with regulatory standards through automated documentation.
• Improved ergonomic handling and reduced risk of musculoskeletal strain.
• Seamless protocol sharing and collaboration across lab teams or global sites.

Future Trends and Opportunities

Further developments may focus on deeper integration with laboratory information management systems (LIMS), cloud-based data analytics, and artificial intelligence-driven protocol optimization. Expansion of smart pipetting capabilities to robotic liquid handlers and multisite networks will support remote execution and real-time quality control across distributed facilities.

Conclusion

Pipette+ represents a significant advancement in automated pipetting by combining intuitive software, intelligent hardware, and real-time monitoring. The system enhances reproducibility, productivity, and traceability in routine laboratory workflows, laying the groundwork for more efficient and reliable experimental practices.