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SUICIDE INHIBITION OF ONCOGENIC K-RAS G12C PROCEEDS VIA SHIFT TO THE INACTIVE CONFORMATION Rane A. Harrison1, Sang Min Lim2,3, John C. Hunter4, Kenneth D. Westover4, Nathanael S. Gray2,3, John R. Engen1 1Department of Chemistry & Chemical Biology, Northeastern University, Boston,…
Key words
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Conformational Characterization of Calmodulin by Hydrogen Deuterium Exchange Mass Spectrometry Joomi Ahn, Martha Stapels, Michael Eggertson, Keith Fadgen, and Ying Qing Yu Waters Corporation, Milford, MA, U.S. A P P L I C AT I O N B E N…
Key words
deuterium, deuteriumcalmodulin, calmodulinhdx, hdxconformational, conformationalapo, apoholo, holoexchange, exchangehydrogen, hydrogenprotein, proteinuptake, uptakepep, peppepsin, pepsinnanoacquity, nanoacquitycharacterization, characterizationconformation
ACQUITY UPLC M-Class System with HDX Technology Integration of Hydrogen Deuterium Exchange with High Resolution MS QUANT IF Y CHANGES IN P ROT EIN CONFORMAT ION W IT H CONFIDENC E The Waters ® ACQUITY UPLC ® M-Class System with…
Key words
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HIGHER SENSITIVITY, DATA QUALITY AND THROUGHPUT FOR HYDROGEN DEUTERIUM EXCHANGE EXPERIMENTS WITH EXTENDED ION MOBILITY SEPARATION Alexandre F. Gomes[1], Lindsay Morrison[1], Malcolm Anderson[2], Colette Quinn[1] [1] Waters Corporation, 34 Maple St., Milford, MA, 01757, USA [2] Waters Corporation, Stamford Avenue,…
Key words
hdx, hdxcyclic, cyclicpeptides, peptidesdeuterium, deuteriumims, imspeptide, peptidesynapt, synaptpepsin, pepsincoverage, coveragephosb, phosbadc, adcsequence, sequenceexperiments, experimentsleap, leapmobility
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