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Analysis of Antibody siRNA Conjugate Using BioAccord System

 

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Application Note Pharma & Biopharma Mass Spectrometric Characterization of Antibody-siRNA Conjugates using the Agilent 6545XT AdvanceBio LC/Q‑TOF Author David L. Wong Agilent Technologies, Inc. Abstract Small interfering RNAs (siRNAs) are a promising type of RNA-based therapeutic drugs that demonstrate effectiveness…
Key words
sirna, sirnamab, mabconjugates, conjugatesintact, intactcounts, countsdeglycosylated, deglycosylateddeconvoluted, deconvolutednative, nativeamu, amumass, massadvancebio, advancebiorna, rnaantibody, antibodysirnas, sirnaslinker
[ TECHNOLOGY BRIEF ] Analysis of Antibody Drug Conjugates (ADCs) by Native Mass Spectrometry on the BioAccord System Henry Shion, Ying Qing Yu, and Weibin Chen Waters Corporation, Milford, MA, USA Drug-to-Antibody Ratio (DAR) determination of Lys and Cys conjugated…
Key words
bioaccord, bioaccordconjugated, conjugatedadc, adcdar, daradcs, adcsnative, nativedrug, drugsystem, systemantibody, antibodysec, seccovalent, covalentbrief, briefconjugates, conjugatescysteine, cysteinelysine
[ TECHNOLOGY BRIEF ] Antibody Drug Conjugate (ADC) Load Characterization and Analysis Using the BioAccord and Nano DSC Systems Colette Quinn and Henry Shion Waters Corporation, Milford, MA, USA A physicochemical analysis of antibody drug conjugate (ADC) focusing on the…
Key words
dsc, dscdrug, drugantibody, antibodyadcs, adcsconjugate, conjugatebioaccord, bioaccordhydrophobic, hydrophobicbiochemical, biochemicalconjugates, conjugatesadc, adcnano, nanopayload, payloadbiophysical, biophysicalbrief, briefdar
Application Note Application of a Mass Confirmation Workflow for Biotherapeutics Screening Henry Shion, Scott J. Berger, Ying Qing Yu Waters Corporation Abstract In the study, we report the development of a higher throughput intact mass confirmation workflow using the BioAccord…
Key words
confirmation, confirmationmass, massnative, nativereversed, reversedintact, intactacquity, acquityantibody, antibodyrda, rdasec, secthroughput, throughputphase, phasestatus, statusnoncovalent, noncovalentuplc, uplctics
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