High Resolution and Rapid Peptide Mapping of Monoclonal Antibody Using an Agilent 1290 Infi nity UHPLC and an Agilent 6550 iFunnel Q-TOF LC/MS SystemApplications | 2013 | Agilent TechnologiesInstrumentationLC/TOF, LC/HRMS, LC/MS, LC/MS/MSIndustriesPharma & BiopharmaManufacturerAgilent TechnologiesKey wordspeptide, mapping, counts, superﬁcially, sequence, jetstream, identiﬁed, monoclonal, acquisition, antibody, efﬁciency, ptms, time, charge, agilent, ﬂow, column, advancebio, map, martosella, resolution, sequences, added, coverage, min, resolving, porous, mab, zhu, sheath, maximize, tang, peptides, novel, ning, conﬁdent, report, drying, biologic, advancement, interpreted, second, post, alex, james, generated, system, sample, rate, gas
Peptide Mapping - Agilent BioHPLC Columns Application Compendium
Agilent-NISTmAbPeptide MappingAgilent BioHPLC ColumnsApplication CompendiumContentsAgilent-NISTmAb Standard (P/N 5191-5744; 5191-5745) was aliquoted fromNISTmAb RM 8671 batch. Quality control (QC) testing is performed usingAgilent LC-MS system. QC batch release test includes aggregate profile, chargevariants and intact mass information. A certificate of analysis...
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An Integrated Workflow for Peptide Mapping of Monoclonal Antibodies
An Integrated Workflow for PeptideMapping of Monoclonal AntibodiesApplication NoteBiotherapeutics and BiosimilarsAuthorsIntroductionDavid L. WongMonoclonal antibodies (mAbs) represent one of the fastest growing classes of drugsin the pharmaceutical industry. As a protein drug, the manufacturing of an mAb frominitial expression to commercialization...
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Making Peptide Mapping Routine with the Agilent 6545XT AdvanceBio LC/Q-TOF
Making Peptide Mapping Routinewith the Agilent 6545XT AdvanceBioLC/Q-TOFApplication NoteAuthorsIntroductionDavid L. WongMonoclonal antibodies (mAbs) comprise a rapidly growing group of protein-basedbiomolecules being researched. Due to the heterogeneous nature of protein drugs,extensive analytical characterization is required.Agilent Technologies, Inc.Santa Clara, CA, USAJing ChenAgilent...
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Peptide Mapping of Innovator and Biosimilar Monoclonal Antibody Using an Agilent 1290 Infinity UHPLC Coupled to an Agilent 6550 iFunnel Q-TOF LC/MS System
Peptide Mapping of Innovator andBiosimilar Monoclonal AntibodyUsing an Agilent 1290 Infinity UHPLCCoupled to an Agilent 6550 iFunnelQ-TOF LC/MS SystemApplication NoteAuthorIntroductionRavindra GudihalMonoclonal antibodies (mAbs) are becoming one of the important classes ofbiomolecules for the treatment of various cancers. Biosimilar mAbs, which...
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