Investigating the increased lifespan in C. elegans daf-2 mutants by 4D-Lipidomics
Applications | 2019 | BrukerInstrumentation
Ion Mobility, LC/TOF, LC/HRMS, LC/MS, LC/MS/MS
IndustriesLipidomics
ManufacturerBruker
Key wordsccs, lipid, characteristic, negative, values, pasef, lipids, timstof, metaboscape, lipidblast, ccspredict, positive, spectra, wild, assignment, generated, merged, pro, mode, automatically, headgroups, nematode, list, spectrum, ketene, data, assigned, mobility, based, pinpointing, survey, phosphocholine, rex, fatty, enabled, generate, were, isotopic, confidence, complementary, acquired, lpc, precursor, analyte, extraction, matching, coding, extracted, annotations, neutral
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4D-Lipidomics™ workflow for increased throughput
2021|Bruker|Applications
4D-Lipidomics™ workflow for increased throughput Lipid profiling from complex lipid extracts can be a challenging and time consuming task. The high complexity of samples and co-elution of isobaric or isomeric compounds complicate the confident annotation of lipids. The presented 4D-Lipidomics…
Key words
ccs, ccsannotation, annotationlipid, lipidannotations, annotationslipids, lipidstimstof, timstofaware, awarebased, basedcoverage, coveragevalues, valuescan, candeep, deepmobility, mobilityrule, ruleannotated
Using Parallel Accumulation Serial Fragmentation (PASEF) to speed up untargeted 4D lipidomics LC-MS/MS workflows
2019|Bruker|Applications
Using Parallel Accumulation Serial Fragmentation (PASEF) to speed up untargeted 4D lipidomics LC-MS/MS workflows The search for new and validated biomarkers is of particular interest in clinical areas like oncology [1, 2] or neurology [3]. As lipids play an important…
Key words
pasef, pasefintensity, intensitybruker, brukermobility, mobilityccspredict, ccspredicttimstof, timstoflipids, lipidslipid, lipidspiked, spikedelute, elutewere, wereuhplc, uhplcapproach, approachpro, profeaturing
CCS-aware SpatialOMx® enables highly confident and automatic lipid annotations with regiospecific context
2021|Bruker|Applications
Intensity (arb. unit) 132% 0% 100% PS 38:1 m/z 816.5747 ± 0.0122 1/K0 1.433 ± 0.01 Intensity (arb. unit) Mobility [1/K0] 136% 0% 100% PE 20:1_22:6 m/z 816.5517 ± 0.0122 1/K0 1.404 ± 0.01 m/z 1 mm CCS-aware SpatialOMx® enables…
Key words
ccs, ccsmaldi, maldispatialomx, spatialomximaging, imagingaware, awareannotation, annotationtims, timsmobility, mobilityannotated, annotatedannotations, annotationspasef, pasefbucket, bucketlipid, lipidsegmentation, segmentationimages
Incorporating CCS values to enable 4-dimensional annotation of metabolic features
2020|Bruker|Applications
Incorporating CCS values to enable 4-dimensional annotation of metabolic features Reliable annotation of metabolites for LC-MS/MS based data requires the adept combination of many parameters. To extend our parameter portfolio we analyzed trapped ion mobility spectrometry (TIMS) data. Introduction Experimental…
Key words
ccs, ccsbremen, bremennovamt, novamtperth, perthvalues, valuescaffeine, caffeinetheobromine, theobromineannotation, annotationbruker, brukerpositive, positiveparaxanthine, paraxanthineurine, urinenegative, negativetimstof, timstofmetabolites