Application Note Modernized Impurity Analysis of the Kinase Inhibitor Imatinib by High-Resolution LC With MS-Compatible Mobile Phases
Applications | 2021 | WatersInstrumentation
Ion Mobility, LC/TOF, LC/HRMS, LC/MS, LC/MS/MS
IndustriesPharma & Biopharma
ManufacturerWaters
Key wordsimatinib, uplc, phenyl, hexyl, kinase, vion, csh, ims, phases, qtof, nine, molecular, separation, corroborate, flight, impurity, spurious, substituents, mobile, heteroatoms, stationary, modernized, compatible, mass, bear, precursor, analysis, modernization, surface, component, cited, acquity, propose, spectra, sensitive, inhibitors, inhibitor, use, conjugated, accurate, formulas, corresponds, observation, ligand, facilitated, overlaid, pairing, begin, ever, spectrometry
Similar PDF
UPLC COLUMNS AND CONSUMABLES
2014|Waters|Brochures and specifications
UPLC COLUMNS AND CONSUMABLESUPLC Columnswww.waters.com/uplccolumns109 TABLE OF CONT ENTSIntroduction........................................................................................................................................................................ 111UPLC Columns........................................................................................................................................................................111Waters UPLC Particle Technology..........................................................................................................................................111CORTECS UPLC 1.6 µm Columns.................................................................................................................................... 112CORTECS UPLC C18+ Columns...............................................................................................................................................112CORTECS UPLC C18 Columns.................................................................................................................................................113CORTECS UPLC HILIC Columns..............................................................................................................................................113ACQUITY UPLC CSH Columns......................................................................................................................................... 116ACQUITY UPLC CSH C18 Columns.........................................................................................................................................116ACQUITY UPLC CSH Fluoro-Phenyl Columns.......................................................................................................................117ACQUITY UPLC...
Key words
uplc, uplcbeh, behphenyl, phenylcsh, cshhilic, hilichss, hsskit, kitacquity, acquitycolumns, columnscortecs, cortecsfluoro, fluoromethod, methodcyano, cyanohexyl, hexyltransfer
Lipid Nanoparticle Compositional Analysis Using Charged Surface Hybrid Phenyl-Hexyl Separation With Evaporative Light Scattering Detection
2021|Waters|Applications
Application NoteLipid Nanoparticle Compositional AnalysisUsing Charged Surface Hybrid Phenyl-HexylSeparation With Evaporative Light ScatteringDetectionBonnie A. Alden, Giorgis Isaac, Weibin Chen, Matthew A. LauberWaters CorporationNeed Help? To learn more about how Waters can help you in your efforts againstCOVID-19, please contact theCOVID-19...
Key words
lipid, lipidhexyl, hexylphenyl, phenylevaporative, evaporativehydrophobicity, hydrophobicityscattering, scatteringstationary, stationaryhelp, helpacquity, acquitynanoparticle, nanoparticlenanoparticles, nanoparticlescsh, cshlight, lightgarnering, garneringuplc
Structural Elucidation of Unknown Impurities in the Kinase Inhibitor Imatinib Using UHPLC and High-Resolution Mass Spectrometry
2023|Waters|Applications
Application NoteStructural Elucidation of Unknown Impuritiesin the Kinase Inhibitor Imatinib Using UHPLCand High-Resolution Mass SpectrometryPeng Chen, Matthew A. LauberWaters CorporationAbstractA UHPLC-HRMS method has revealed previously unidentified impurities in the synthesis of the kinase inhibitor,imatinib. Four specific impurities were structurally elucidated...
Key words
imatinib, imatinibkinase, kinaseelucidation, elucidationinhibitor, inhibitorstructural, structuralimpurities, impuritiesunknown, unknownuhplc, uhplcspectrometry, spectrometryresolution, resolutionmass, masshigh, highusing, usingchemical, chemicaluplc
A Systematic Approach Towards UPLC® Method Development
2012|Waters|Presentations
Session F6A Systematic Approach TowardsUPLC® Method DevelopmentEsa [email protected]: +358-9-5659 6288Fax: +358-9-5659 6282Waters FinlandKutomotie 1600380 Helsinki©2011 Waters Corporation1 Challenges of Method Development Chromatographic methods are developed for differentapplications constantly, like throughout the drugdevelopment process— Samples vary in complexity— Redundancy exists across an...
Key words
csh, cshphenyl, phenylselectivity, selectivityuplc, uplcacetonitrile, acetonitrilemethanol, methanolhexyl, hexylfluoro, fluorophase, phasedevelopment, developmentsystematic, systematicdesign, designmobile, mobilemodifier, modifierqbd