Agilent LC AND LC/MS Catalog - Your Essential Resource for Columns & Supplies

Significance of the topic

Liquid chromatography (LC) coupled with mass spectrometry (LC/MS) and related spectroscopy techniques form the backbone of modern analytical chemistry. They are widely used for separation, identification, and quantitation of compounds in fields ranging from pharmaceutical development and quality control to environmental monitoring and food safety. An up-to-date, comprehensive catalog of columns, consumables, and instrumentation ensures laboratories can optimize workflows, maintain reproducibility, and achieve high sensitivity and throughput.

Objectives and overview

This Essential Chromatography & Spectroscopy Catalog presents Agilent’s full portfolio of LC and LC/MS solutions designed to meet diverse analytical demands. The objectives are to:

• Provide a single reference for product specifications, ordering information, and troubleshooting tips
• Illustrate compatibility across HPLC, UHPLC, capillary, preparative LC, and LC/MS systems
• Highlight selection guides, application notes, and maintenance recommendations

Used methodology and instrumentation

Agilent’s product range is organized by application type and includes both hardware and consumables:

• LC systems: 1290, 1260, 1220 Infinity LCs with binary/quaternary pumps and specialized low-dispersion tubing
• LC/MS platforms: single-quadruple (6100 series), accurate-mass TOF (6200 series), triple-quadruple (6400 series), and Q-TOF (6500 series) instruments
• Columns: ZORBAX and Poroshell HPLC/UHPLC columns for small molecules, biomolecules, GPC/SEC, and HILIC separations
• Supplies: high-precision capillaries (stainless steel, PEEK-lined, titanium), fittings (Swagelok, PEEK finger-tight, removable 1200 bar fittings), autosampler needles and vials
• Consumables: in-line filters, solvent filters/degassers, pump seals/pistons, purge valves, inlet and outlet valves, tubing, and racks

Main results and discussion

The catalog demonstrates how Agilent’s integrated solutions achieve:

• Superior reproducibility with column-to-column performance reports and passivated flow paths
• High throughput via UHPLC-grade columns, low dead-volume fittings, and rapid autosamplers
• Enhanced sensitivity through Agilent Jet Stream™ electrospray and Ultra High Definition TOF technology
• Robustness supported by sapphire pistons, spring-loaded seal assemblies, and biocompatible titanium capillaries
• Ease of maintenance with modular parts kits, detailed torque-tightening procedures, and service plans

Benefits and practical applications

Agilent’s catalog addresses real-world analytical challenges in:

• Pharmaceutical analysis and compliance (dissolution, impurity profiling)
• Forensics and toxicology (drug screening, trace evidence)
• Food safety (pesticide residue, mycotoxin monitoring)
• Environmental testing (water quality, pollutant quantitation)
• Biopharmaceutical R&D (proteomics, metabolomics, biomarker discovery)

Future trends and opportunities

Emerging directions in chromatography and spectroscopy include:

• Microfluidic and chip-based LC/MS for single-cell and low-volume analyses
• Green chemistry approaches with aqueous UHPLC and reduced solvent consumption
• Increased automation and remote monitoring via integrated software and cloud-based diagnostics
• Artificial intelligence–driven method optimization and predictive maintenance
• Expanded high-resolution separations for complex biomolecules and advanced materials

Conclusion

This comprehensive catalog serves as an essential resource for selecting Agilent chromatography and spectroscopy products. By uniting instrumentation, consumables, and support services, it enables laboratories to maximize performance, maintain regulatory compliance, and accelerate analytical projects across diverse industries.

Reference

Agilent Technologies, Inc. The Essential Chromatography & Spectroscopy Catalog: LC & LC/MS. October 2012.