ASMS 2021: Application of Vacuum Jacketed UHPLC Columns Coupled with Mass Spectrometry in High Throughput Pharmaceutical Analysis | LabRulez LCMS
 

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Streamlining Discovery Microsomal Clearance andMetabolite ID Analysis using a TripleTOF® 6600 SystemSWATH® Acquisition 2.0 for Small Molecule ApplicationsMustafa Varoglua*, Lieu Nguyena, Xiaowei Hea**, Keith J. GoodmanbaCubist Pharmaceuticals, Lexington, MA, bSCIEX, Framingham, MA,Present address: *Alnylam Pharmaceuticals, Cambridge, MA, **Eisai Inc, Andover,...
Key words
swath, swathclearance, clearancemetabolite, metabolitequantitative, quantitativeacquisition, acquisitionmicrosomal, microsomalhigh, highproduct, productdiclofenac, diclofenacverapamil, verapamilqualitative, qualitativeion, iondedicated, dedicateddata, dataclint
A FAST SCREENING METHOD FORMETABOLITE ID WITH ACQUITY UPLC™,QUATTRO PREMIER™ XE AND METABOLYNX™Jose Castro-Perez and Lisa CaltonWaters Corporation, Milford, MA, USAINTRODUCTIONThe MetaboLynx™ Application Manager for MassLynx™Software detects putative biotransformations forIn vitro metabolism studies have become an integralexpected and unexpected metabolites....
Key words
metabolynx, metabolynxquattro, quattrouplc, uplcpremier, premierdata, datametabolite, metaboliteacquity, acquitystudies, studiesmetabolites, metabolitesfast, fastbrowser, browserchromatographic, chromatographiccastro, castrooutpace, outpacemetabolism
Effect of MS Scan Speed on UPLC Peak Separation and MetaboliteIdentification: Time-of-Flight HRMS vs. OrbitrapYun W. Alelyunas, Mark D. Wrona, Kevin Cook, Stephen McDonald, Paul D. RainvilleWaters Corporation, Milford, MA, USAA P P L I C AT I O N...
Key words
metabolite, metaboliteglyburide, glyburidescanning, scanningscan, scanresolution, resolutionmetabolites, metabolitesmicrosomal, microsomalhrms, hrmsincubate, incubateuplc, uplcnegatives, negativesslower, slowerequally, equallyfast, fastspeeds
A P P LICAT ION SOLUT IONS FO RM ETABOLIT E IDENT IFICAT ION A P P L I C AT I O N S O L U T I O N S F O R M E TA B O...
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synapt, synaptuplc, uplcmetabolite, metabolitemetabolynx, metabolynxwaters, watersmassfragment, massfragmenthdms, hdmsdrug, drugmetabolites, metabolitesetabolite, etabolitedata, datafragment, fragmentgsh, gshvivo, vivoacquity
 

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Streamlining Discovery Microsomal Clearance andMetabolite ID Analysis using a TripleTOF® 6600 SystemSWATH® Acquisition 2.0 for Small Molecule ApplicationsMustafa Varoglua*, Lieu Nguyena, Xiaowei Hea**, Keith J. GoodmanbaCubist Pharmaceuticals, Lexington, MA, bSCIEX, Framingham, MA,Present address: *Alnylam Pharmaceuticals, Cambridge, MA, **Eisai Inc, Andover,...
Key words
swath, swathclearance, clearancemetabolite, metabolitequantitative, quantitativeacquisition, acquisitionmicrosomal, microsomalhigh, highproduct, productdiclofenac, diclofenacverapamil, verapamilqualitative, qualitativeion, iondedicated, dedicateddata, dataclint
A FAST SCREENING METHOD FORMETABOLITE ID WITH ACQUITY UPLC™,QUATTRO PREMIER™ XE AND METABOLYNX™Jose Castro-Perez and Lisa CaltonWaters Corporation, Milford, MA, USAINTRODUCTIONThe MetaboLynx™ Application Manager for MassLynx™Software detects putative biotransformations forIn vitro metabolism studies have become an integralexpected and unexpected metabolites....
Key words
metabolynx, metabolynxquattro, quattrouplc, uplcpremier, premierdata, datametabolite, metaboliteacquity, acquitystudies, studiesmetabolites, metabolitesfast, fastbrowser, browserchromatographic, chromatographiccastro, castrooutpace, outpacemetabolism
Effect of MS Scan Speed on UPLC Peak Separation and MetaboliteIdentification: Time-of-Flight HRMS vs. OrbitrapYun W. Alelyunas, Mark D. Wrona, Kevin Cook, Stephen McDonald, Paul D. RainvilleWaters Corporation, Milford, MA, USAA P P L I C AT I O N...
Key words
metabolite, metaboliteglyburide, glyburidescanning, scanningscan, scanresolution, resolutionmetabolites, metabolitesmicrosomal, microsomalhrms, hrmsincubate, incubateuplc, uplcnegatives, negativesslower, slowerequally, equallyfast, fastspeeds
A P P LICAT ION SOLUT IONS FO RM ETABOLIT E IDENT IFICAT ION A P P L I C AT I O N S O L U T I O N S F O R M E TA B O...
Key words
synapt, synaptuplc, uplcmetabolite, metabolitemetabolynx, metabolynxwaters, watersmassfragment, massfragmenthdms, hdmsdrug, drugmetabolites, metabolitesetabolite, etabolitedata, datafragment, fragmentgsh, gshvivo, vivoacquity
 

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