ASMS 2021: Application of Vacuum Jacketed UHPLC Columns Coupled with Mass Spectrometry in High Throughput Pharmaceutical Analysis | LabRulez LCMS
 

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Streamlining Discovery Microsomal Clearance andMetabolite ID Analysis using a TripleTOF® 6600 SystemSWATH® Acquisition 2.0 for Small Molecule ApplicationsMustafa Varoglua*, Lieu Nguyena, Xiaowei Hea**, Keith J. GoodmanbaCubist Pharmaceuticals, Lexington, MA, bSCIEX, Framingham, MA,Present address: *Alnylam Pharmaceuticals, Cambridge, MA, **Eisai Inc, Andover,...
Key words
swath, swathclearance, clearancemetabolite, metabolitequantitative, quantitativeacquisition, acquisitionmicrosomal, microsomalhigh, highproduct, productdiclofenac, diclofenacverapamil, verapamilqualitative, qualitativeion, iondedicated, dedicateddata, dataclint
Ultra-fast LCMS analysis of Antiarrhythmic drugs in plasmaDavide Vecchietti1; Kyoko Watanabe1; Keiko Matsumoto1; Mikael Levi1; Hidetoshi Terada1; Takato Uchikata1; Satoshi Akita11 Shimadzu Corporation., Kyoto, Japan,1. Introduction2.2 Sample preparation3.2 Method evaluation: Gradient elution modeThe need for high throughput liquid chromatography-tandem mass...
Key words
llmi, llmipecision, pecisionulmi, ulmimqc, mqcverapamil, verapamilatenolol, atenololday, daybeneficial, beneficialsotalol, sotalolquantitation, quantitationdrug, drugelution, elutiontens, tensmetoprolol, metoprololpropranolol
A FAST SCREENING METHOD FORMETABOLITE ID WITH ACQUITY UPLC™,QUATTRO PREMIER™ XE AND METABOLYNX™Jose Castro-Perez and Lisa CaltonWaters Corporation, Milford, MA, USAINTRODUCTIONThe MetaboLynx™ Application Manager for MassLynx™Software detects putative biotransformations forIn vitro metabolism studies have become an integralexpected and unexpected metabolites....
Key words
metabolynx, metabolynxquattro, quattrouplc, uplcpremier, premierdata, datametabolite, metaboliteacquity, acquitystudies, studiesfast, fastmetabolites, metabolitesbrowser, browserchromatographic, chromatographiccastro, castrooutpace, outpacemetabolism
Effect of MS Scan Speed on UPLC Peak Separation and MetaboliteIdentification: Time-of-Flight HRMS vs. OrbitrapYun W. Alelyunas, Mark D. Wrona, Kevin Cook, Stephen McDonald, Paul D. RainvilleWaters Corporation, Milford, MA, USAA P P L I C AT I O N...
Key words
metabolite, metaboliteglyburide, glyburidescanning, scanningscan, scanresolution, resolutionmetabolites, metabolitesmicrosomal, microsomalincubate, incubatehrms, hrmsnegatives, negativesuplc, uplcslower, slowerequally, equallyfast, fastspeeds
 

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Streamlining Discovery Microsomal Clearance andMetabolite ID Analysis using a TripleTOF® 6600 SystemSWATH® Acquisition 2.0 for Small Molecule ApplicationsMustafa Varoglua*, Lieu Nguyena, Xiaowei Hea**, Keith J. GoodmanbaCubist Pharmaceuticals, Lexington, MA, bSCIEX, Framingham, MA,Present address: *Alnylam Pharmaceuticals, Cambridge, MA, **Eisai Inc, Andover,...
Key words
swath, swathclearance, clearancemetabolite, metabolitequantitative, quantitativeacquisition, acquisitionmicrosomal, microsomalhigh, highproduct, productdiclofenac, diclofenacverapamil, verapamilqualitative, qualitativeion, iondedicated, dedicateddata, dataclint
Ultra-fast LCMS analysis of Antiarrhythmic drugs in plasmaDavide Vecchietti1; Kyoko Watanabe1; Keiko Matsumoto1; Mikael Levi1; Hidetoshi Terada1; Takato Uchikata1; Satoshi Akita11 Shimadzu Corporation., Kyoto, Japan,1. Introduction2.2 Sample preparation3.2 Method evaluation: Gradient elution modeThe need for high throughput liquid chromatography-tandem mass...
Key words
llmi, llmipecision, pecisionulmi, ulmimqc, mqcverapamil, verapamilatenolol, atenololday, daybeneficial, beneficialsotalol, sotalolquantitation, quantitationdrug, drugelution, elutiontens, tensmetoprolol, metoprololpropranolol
A FAST SCREENING METHOD FORMETABOLITE ID WITH ACQUITY UPLC™,QUATTRO PREMIER™ XE AND METABOLYNX™Jose Castro-Perez and Lisa CaltonWaters Corporation, Milford, MA, USAINTRODUCTIONThe MetaboLynx™ Application Manager for MassLynx™Software detects putative biotransformations forIn vitro metabolism studies have become an integralexpected and unexpected metabolites....
Key words
metabolynx, metabolynxquattro, quattrouplc, uplcpremier, premierdata, datametabolite, metaboliteacquity, acquitystudies, studiesfast, fastmetabolites, metabolitesbrowser, browserchromatographic, chromatographiccastro, castrooutpace, outpacemetabolism
Effect of MS Scan Speed on UPLC Peak Separation and MetaboliteIdentification: Time-of-Flight HRMS vs. OrbitrapYun W. Alelyunas, Mark D. Wrona, Kevin Cook, Stephen McDonald, Paul D. RainvilleWaters Corporation, Milford, MA, USAA P P L I C AT I O N...
Key words
metabolite, metaboliteglyburide, glyburidescanning, scanningscan, scanresolution, resolutionmetabolites, metabolitesmicrosomal, microsomalincubate, incubatehrms, hrmsnegatives, negativesuplc, uplcslower, slowerequally, equallyfast, fastspeeds
 

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