ASMS 2021: Application of Vacuum Jacketed UHPLC Columns Coupled with Mass Spectrometry in High Throughput Pharmaceutical Analysis | LabRulez LCMS_EN
 

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Streamlining Discovery Microsomal Clearance andMetabolite ID Analysis using a TripleTOF® 6600 SystemSWATH® Acquisition 2.0 for Small Molecule ApplicationsMustafa Varoglua*, Lieu Nguyena, Xiaowei Hea**, Keith J. GoodmanbaCubist Pharmaceuticals, Lexington, MA, bSCIEX, Framingham, MA,Present address: *Alnylam Pharmaceuticals, Cambridge, MA, **Eisai Inc, Andover,...
Key words
swath, swathclearance, clearancemetabolite, metabolitequantitative, quantitativeacquisition, acquisitionhigh, highmicrosomal, microsomalproduct, productdiclofenac, diclofenacverapamil, verapamilqualitative, qualitativeion, iondedicated, dedicateddata, dataclint
Microflow Chromatography: A Key to More Sensitive Met IDUse of OptiFlow® Turbo V Source with Triple TOF® 6600+ System to Identification and Characterizationof Small Molecule MetabolitesCarmai Seto1, Alina Dindyal-Popescu1, Rolf Kern21SCIEX, Concord, Ontario, 2SCIEX, Redwood City, CAIn early-stage pharmaceutical research,...
Key words
microflow, microflowmetabolitepilot, metabolitepilotmetabolites, metabolitesflow, flowverapamil, verapamilseen, seendesmethyl, desmethylobserved, observedtamoxifen, tamoxifensensitivity, sensitivityhigh, highacquired, acquiredmetabolite, metabolitemolecule, moleculemore
A FAST SCREENING METHOD FORMETABOLITE ID WITH ACQUITY UPLC™,QUATTRO PREMIER™ XE AND METABOLYNX™Jose Castro-Perez and Lisa CaltonWaters Corporation, Milford, MA, USAINTRODUCTIONThe MetaboLynx™ Application Manager for MassLynx™Software detects putative biotransformations forIn vitro metabolism studies have become an integralexpected and unexpected metabolites....
Key words
metabolynx, metabolynxquattro, quattrouplc, uplcpremier, premierdata, dataacquity, acquitymetabolite, metabolitestudies, studiesmetabolites, metabolitesfast, fastbrowser, browsercastro, castrooutpace, outpacechromatographic, chromatographicmetabolism
Effect of MS Scan Speed on UPLC Peak Separation and MetaboliteIdentification: Time-of-Flight HRMS vs. OrbitrapYun W. Alelyunas, Mark D. Wrona, Kevin Cook, Stephen McDonald, Paul D. RainvilleWaters Corporation, Milford, MA, USAA P P L I C AT I O N...
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metabolite, metaboliteglyburide, glyburidescanning, scanningscan, scanresolution, resolutionmetabolites, metabolitesmicrosomal, microsomalincubate, incubatehrms, hrmsnegatives, negativesuplc, uplcslower, slowerequally, equallyfast, fastspeeds
 

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Streamlining Discovery Microsomal Clearance andMetabolite ID Analysis using a TripleTOF® 6600 SystemSWATH® Acquisition 2.0 for Small Molecule ApplicationsMustafa Varoglua*, Lieu Nguyena, Xiaowei Hea**, Keith J. GoodmanbaCubist Pharmaceuticals, Lexington, MA, bSCIEX, Framingham, MA,Present address: *Alnylam Pharmaceuticals, Cambridge, MA, **Eisai Inc, Andover,...
Key words
swath, swathclearance, clearancemetabolite, metabolitequantitative, quantitativeacquisition, acquisitionhigh, highmicrosomal, microsomalproduct, productdiclofenac, diclofenacverapamil, verapamilqualitative, qualitativeion, iondedicated, dedicateddata, dataclint
Microflow Chromatography: A Key to More Sensitive Met IDUse of OptiFlow® Turbo V Source with Triple TOF® 6600+ System to Identification and Characterizationof Small Molecule MetabolitesCarmai Seto1, Alina Dindyal-Popescu1, Rolf Kern21SCIEX, Concord, Ontario, 2SCIEX, Redwood City, CAIn early-stage pharmaceutical research,...
Key words
microflow, microflowmetabolitepilot, metabolitepilotmetabolites, metabolitesflow, flowverapamil, verapamilseen, seendesmethyl, desmethylobserved, observedtamoxifen, tamoxifensensitivity, sensitivityhigh, highacquired, acquiredmetabolite, metabolitemolecule, moleculemore
A FAST SCREENING METHOD FORMETABOLITE ID WITH ACQUITY UPLC™,QUATTRO PREMIER™ XE AND METABOLYNX™Jose Castro-Perez and Lisa CaltonWaters Corporation, Milford, MA, USAINTRODUCTIONThe MetaboLynx™ Application Manager for MassLynx™Software detects putative biotransformations forIn vitro metabolism studies have become an integralexpected and unexpected metabolites....
Key words
metabolynx, metabolynxquattro, quattrouplc, uplcpremier, premierdata, dataacquity, acquitymetabolite, metabolitestudies, studiesmetabolites, metabolitesfast, fastbrowser, browsercastro, castrooutpace, outpacechromatographic, chromatographicmetabolism
Effect of MS Scan Speed on UPLC Peak Separation and MetaboliteIdentification: Time-of-Flight HRMS vs. OrbitrapYun W. Alelyunas, Mark D. Wrona, Kevin Cook, Stephen McDonald, Paul D. RainvilleWaters Corporation, Milford, MA, USAA P P L I C AT I O N...
Key words
metabolite, metaboliteglyburide, glyburidescanning, scanningscan, scanresolution, resolutionmetabolites, metabolitesmicrosomal, microsomalincubate, incubatehrms, hrmsnegatives, negativesuplc, uplcslower, slowerequally, equallyfast, fastspeeds
 

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