ASMS 2021: Improvements in the bioanalytical method performance for steroid phosphates using a hybrid surface barrier to minimize analyte-metal surface interactions | LabRulez LCMS_EN
 

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A RAPID METHOD FOR THE ULTRA-SENSITIVE QUANTIFICATION OF FLUTICASONE PROPIONATE AND SALMETEROL XINAFOATEFROM HUMAN PLASMAAuthors: Nikunj Tanna, Lauren Mullin & Michael JonesAffiliations: Waters Corporation, Milford, MA, USAINTRODUCTIONMETHODSRESULTSDISCUSSIONFluticasone propionate (Figure 1a) (1) is a synthetictrifluorinated glucocorticoid receptor agonist with antiallergic,anti-inflammatory and...
Key words
fluticasone, fluticasonesalmeterol, salmeterolxinafoate, xinafoatepropionate, propionateaccuracy, accuracyinter, interday, daymqc, mqchqc, hqclqc, lqcplasma, plasmahuman, humancone, coneseritide, seritidecurve
Development of a SPE LC-MS/MS Method for the BioanalyticalQuantification of Salmon Calcitonin from Human SerumNikunj Tanna and Mary LameWaters Corporation, Milford, MA, USAAPPLICATION BENEFITS■■■■Sensitive and flexible platform forSalmon calcitonin (sCT) is a 32 amino acid (MW 3439.1 Da) syntheticquantification of...
Key words
calcitonin, calcitoninsalmon, salmonquantification, quantificationoasis, oasisspe, spebioanalytical, bioanalyticalserum, serumsct, sctwcx, wcxdevelopment, developmentrecovery, recoveryhuman, humanprotein, proteinprecipitation, precipitationxevo
Application NoteImprovements in Sensitivity for Quantification of SteroidPhosphate Drugs Using ACQUITY PREMIER andMaxPeak HPS ColumnsNikunj Tanna, Robert S. Plumb, Lauren MullinWaters Corporation AbstractAnalytes with electron rich moieties such as phosphate and carboxylate groups are susceptible tochelation with metal surfaces across the...
Key words
hps, hpspremier, premiermaxpeak, maxpeakacquity, acquityphosphate, phosphatehydrocortisone, hydrocortisonedexamethasone, dexamethasonesystem, systemstandard, standardxevo, xevodmso, dmsocolumn, columnmore, morechemically, chemicallysurfaces
IMPROVING CHROMATOGRAPHIC PERFORMANCE FOR METALSENSITIVE ANALYTES USING HYBRID SURFACE BARRIER TECHNOLOGYNikunj Tanna, Robert S. Plumb, Kim MulderWaters Corporation, 34 Maple Street, Milford, MA , USAINTRODUCTIONRESULTSAnalytes with electron rich moieties such asphosphate and carboxylate groups aresusceptible to chelation with metal surfaces...
Key words
acquity, acquitypremier, premierperformance, performancedexamethasone, dexamethasonephosphate, phosphatemetal, metaltechnology, technologyplasma, plasmaconventional, conventionalchromatographic, chromatographichps, hpshst, hstmaxpeak, maxpeakhuman, humanextracted
 

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A RAPID METHOD FOR THE ULTRA-SENSITIVE QUANTIFICATION OF FLUTICASONE PROPIONATE AND SALMETEROL XINAFOATEFROM HUMAN PLASMAAuthors: Nikunj Tanna, Lauren Mullin & Michael JonesAffiliations: Waters Corporation, Milford, MA, USAINTRODUCTIONMETHODSRESULTSDISCUSSIONFluticasone propionate (Figure 1a) (1) is a synthetictrifluorinated glucocorticoid receptor agonist with antiallergic,anti-inflammatory and...
Key words
fluticasone, fluticasonesalmeterol, salmeterolxinafoate, xinafoatepropionate, propionateaccuracy, accuracyinter, interday, daymqc, mqchqc, hqclqc, lqcplasma, plasmahuman, humancone, coneseritide, seritidecurve
Development of a SPE LC-MS/MS Method for the BioanalyticalQuantification of Salmon Calcitonin from Human SerumNikunj Tanna and Mary LameWaters Corporation, Milford, MA, USAAPPLICATION BENEFITS■■■■Sensitive and flexible platform forSalmon calcitonin (sCT) is a 32 amino acid (MW 3439.1 Da) syntheticquantification of...
Key words
calcitonin, calcitoninsalmon, salmonquantification, quantificationoasis, oasisspe, spebioanalytical, bioanalyticalserum, serumsct, sctwcx, wcxdevelopment, developmentrecovery, recoveryhuman, humanprotein, proteinprecipitation, precipitationxevo
Application NoteImprovements in Sensitivity for Quantification of SteroidPhosphate Drugs Using ACQUITY PREMIER andMaxPeak HPS ColumnsNikunj Tanna, Robert S. Plumb, Lauren MullinWaters Corporation AbstractAnalytes with electron rich moieties such as phosphate and carboxylate groups are susceptible tochelation with metal surfaces across the...
Key words
hps, hpspremier, premiermaxpeak, maxpeakacquity, acquityphosphate, phosphatehydrocortisone, hydrocortisonedexamethasone, dexamethasonesystem, systemstandard, standardxevo, xevodmso, dmsocolumn, columnmore, morechemically, chemicallysurfaces
IMPROVING CHROMATOGRAPHIC PERFORMANCE FOR METALSENSITIVE ANALYTES USING HYBRID SURFACE BARRIER TECHNOLOGYNikunj Tanna, Robert S. Plumb, Kim MulderWaters Corporation, 34 Maple Street, Milford, MA , USAINTRODUCTIONRESULTSAnalytes with electron rich moieties such asphosphate and carboxylate groups aresusceptible to chelation with metal surfaces...
Key words
acquity, acquitypremier, premierperformance, performancedexamethasone, dexamethasonephosphate, phosphatemetal, metaltechnology, technologyplasma, plasmaconventional, conventionalchromatographic, chromatographichps, hpshst, hstmaxpeak, maxpeakhuman, humanextracted
 

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