ANDREW+ FOR BIOPHARMACEUTICALS - Your Lab’s Most Valuable PartnerAndrew+ the

Significance of Topic

The Andrew+ Pipetting Robot combined with OneLab software addresses critical needs in biopharmaceutical laboratories for precise liquid handling, reproducibility, and full experimental traceability. Automated pipetting and workflow management reduce human error and accelerate routine tasks, supporting high-throughput screening, method development, and regulated environments.

Objectives and Study Overview

This application note introduces the Andrew+ system as a versatile solution for automating common lab operations. It outlines key capabilities—standard curve generation, serial dilutions, concentration normalization, and microplate reformatting—demonstrating how these features improve efficiency and data integrity in antibody purification, amino acid analysis, N-glycan profiling, and mAb subunit assays.

Methodology and Instrumentation Used

Automation workflows were built and executed using OneLab’s intuitive drag-and-drop interface on PC and tablet devices. Protocols leverage:

• Andrew+ Pipetting Robot equipped to work with conventional pipettes, microplates, microtubes, vials, and racked HPLC tubes.
• OneLab Software for protocol design, execution guidance, electronic signature support, and full audit trail compliant with GxP principles.

Main Results and Discussion

Key automated procedures include:

• Standard Curve Creation: Automated generation of calibration standards across concentration gradients for reliable assay quantitation.
• Serial Dilutions: OneLab computes precise dilution volumes considering sample viscosity, ensuring accuracy and consistency.
• Concentration Normalization: The Normalization Wizard automates volume calculations to adjust sample concentrations, cutting manual processing time by over 80%.
• Microplate Reformatting: Flexible aliquoting between diverse labware formats streamlines plate mapping for downstream analyses.

Benefits and Practical Applications

Adopting the Andrew+ system delivers:

• Enhanced reproducibility through standardized, robot-guided liquid handling.
• Comprehensive traceability via electronic records, supporting regulatory compliance.
• Significant time savings on routine tasks, freeing researchers for higher-value activities.
• Scalable workflows adaptable to antibody purification, glycan analysis, and other bioanalytical assays.

Future Trends and Possibilities

Emerging directions include integrating AI-driven protocol optimization, expanding support for more labware formats, and enabling remote monitoring of robotic workflows. Further interoperability with laboratory information management systems (LIMS) will enhance data management and quality control in cGMP environments.

Conclusion

The Andrew+ Pipetting Robot and OneLab software represent a robust platform for automating biopharmaceutical workflows. By combining user-friendly protocol design with precise liquid handling and full data traceability, the system boosts lab productivity, ensures regulatory readiness, and delivers reliable analytical results.