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Ion Mobility-Mass Spectrometry Reveals the Structures and Stabilities of Biotherapeutic Antibody Aggregates

Posters | 2021 | Agilent Technologies | ASMSInstrumentation
Ion Mobility, LC/TOF, LC/HRMS, LC/MS, LC/MS/MS
Industries
Pharma & Biopharma
Manufacturer
Agilent Technologies
Key words
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Poster Reprint ASMS 2023 Poster number ThP 395 Rapid Screening of Bispecific Antibodies and Antibody Impurities using In-source Collision Induced Unfolding coupled with IM-MS Ruwan Kurulugama1, Christian Klein1 ,Harsha Gunawardena2 1Agilent Technologies, Santa Clara, CA 2Janssen Research & Development, Spring…
Key words
source, sourcermsd, rmsddimer, dimerciu, ciutrimer, trimermonomer, monomerunfolding, unfoldingantibodies, antibodiesciusuite, ciusuiteinduced, inducednormalized, normalizedantibody, antibodybispecific, bispecificbuffer, buffernoncovalent
Agilent 6560 Ion Mobility LC/Q-TOF
2023|Agilent Technologies|Brochures and specifications
Add a New Dimension to Your Research Agilent 6560 Ion Mobility LC/Q-TOF Reveal More Details Than Ever Before Does your research involve characterizing small molecules or proteins, increasing metabolite coverage maps, or ensuring food safety? The Agilent 6560 Ion Mobility…
Key words
ccs, ccscollision, collisionvoltage, voltagedrift, driftregion, regionisomers, isomersciu, ciustructural, structuralcharge, chargeextracted, extractedmobility, mobilitydtims, dtimsion, ionmass, massglycomics
Poster Reprint ASMS 2022 Poster number TP298 Automated sample introduction method for high-throughput intact native protein analysis using collision induced unfolding coupled with drift-tube ion mobility-mass spectrometry Ruwan T. Kurulugama1 and Sheher Banu Mohsin2 1Agilent Technologies, Santa Clara, CA 2Agilent…
Key words
ciu, ciuunfolding, unfoldingmobility, mobilitynative, nativesource, sourceprotein, proteinccs, ccsflow, flowexperiments, experimentscollision, collisionciusuite, ciusuiterotationally, rotationallyautomated, automatedinjection, injectionmin
A HIGHLY VERSATILE CYCLIC ION MOBILITY – MASS SPECTROMETER FOR ROUTINE TO IN-DEPTH BIOPHARMACEUTICAL CHARACTERIZATION Brad J. Williams1, Margo Wilson2, S. Hunter Walker2, Greg Adams2, Roy Martin1, and Weibin Chen1 1 Waters Corporation, Milford, MA 01757 USA, 2FUJIFILM Diosynth Biotechnologies,…
Key words
ims, imscyclic, cyclicmobility, mobilitymab, mabsubunit, subunitspectrometer, spectrometerbeneficial, beneficialbayespray, bayespraycollision, collisionbiopharmaceutical, biopharmaceuticalglycan, glycanroutine, routinemass, massreleased, releasedciu
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