Characterization of mRNA Therapeutics Using a Novel LC-MS Based Workflow
Posters | 2021 | Thermo Fisher Scientific | ASMSInstrumentation
LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap
IndustriesPharma & Biopharma
ManufacturerThermo Fisher Scientific
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mRNA direct sequence mapping using automated partial digestion with magnetic nuclease and LC-HRMS
2022|Thermo Fisher Scientific|Applications
Customer application note | 000723 Biotechnology mRNA direct sequence mapping using automated partial digestion with magnetic nuclease and LC-HRMS Authors Application benefits Mark Dickman1, Christina Vanhinsbergh1, Jon Bardsley , Ken Cook , Andrew 2 2 Williamson2, Jennifer Sutton3, Keeley Murphy3…
Key words
mrna, mrnasequence, sequenceegfp, egfptimeretention, timeretentionintensity, intensitydigestion, digestionrna, rnarelative, relativefragments, fragmentsunmodified, unmodifiedmapping, mappingpartial, partialoligonucleotide, oligonucleotideoligoribonucleotide, oligoribonucleotideoligoribonucleotides
BioPharma Finder Software
2021|Thermo Fisher Scientific|Brochures and specifications
Bf Complete biotherapeutic characterization BioPharma Finder Software Transform MS data into actionable results with comprehensive, workflow-driven software Thermo Scientific™ BioPharma Finder™ software provides comprehensive, automated data-processing workflows for the characterization of biologics including peptide mapping, HCP analysis, multi-attribute method (MAM)…
Key words
sequence, sequencemrna, mrnaoligonucleotide, oligonucleotidefinder, finderbiopharma, biopharmadata, datamodifications, modificationssoftware, softwarevisualize, visualizefragment, fragmentcoverage, coverageproteoforms, proteoformsabundance, abundanceprocessing, processingtop
Comprehensive oligonucleotide analysis
2022|Thermo Fisher Scientific|Others
Comprehensive oligonucleotide analysis Oligonucleotide analysis presents multiple analytical and data processing challenges. Thermo Scientific™ BioPharma Finder™ software helps overcome these hurdles to provide confidence with comprehensive capabilities. Bf Intact mass analysis of heavily modified oligonucleotides Oligonucleotide biotherapeutics require multiple modifications…
Key words
mrna, mrnaoligonucleotide, oligonucleotidesequence, sequenceoligonucleotides, oligonucleotidesconfidence, confidencedigestion, digestionmapping, mappingrnase, rnasemass, masssilico, silicofinder, finderheavily, heavilykinetic, kineticisomeric, isomericoligonuclotide
Characterization of mRNA vaccine 5’ and 3’ end products using BioPharma Finder 5.0
2022|Thermo Fisher Scientific|Posters
Characterization of mRNA vaccine 5’ and 3’ end products using BioPharma Finder 5.0 Robert L Ross, Qian Qi, Keeley Murphy, Min Du, Thermo Fisher Scientific, Waltham, MA ABSTRACT Data Analysis 5’ Capping We sought the development of a Thermo Scientific™…
Key words
fragmentation, fragmentationpoly, polynucleases, nucleasesdeconvoluted, deconvolutediprp, iprpsequence, sequencelength, lengthcolleagues, colleaguesmrna, mrnamsms, msmstail, tailannotated, annotatedcoded, codedrepresentation, representationfeedback