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LC-MS Bioanalytical Quantification of a GalNAc-siRNA Conjugate Oligonucleotide Using Semi-Automated Solid Phase Extraction

 

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OLIGONUCLEOTIDE SAMPLE PREP & QUANTITATION: IMPROVED SPE PERFORMANCE USING A NOVEL SEMIAUTOMATED EXTRACTION MANIFOLD Mary Trudeau, Kathryn Brennan , Arjan Timmerman Waters Corporation, 34 Maple Street, Milford, MA , USA INTRODUCTION Solid phase extraction (SPE) is a common technique for…
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[ CONSUMABLES GUIDE BOOK ] Quantifying Oligonucleotides Sample Extraction and LC Tools for Reliable LC-MS Quantitation of Oligonucleotides A Changing Industry There has been a resurgence in synthetic oligonucleotide therapeutics in the past decade, as seen with burgeoning pipelines across…
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Application Note Revolutionizing SPE with Otto SPEcialist: An Easy-to-Use, Software-Driven, Positive Pressure Manifold Kathryn Brennan, Jonathan P. Danaceau, Paula Orens Waters Corporation For forensic toxicology use only. This is an Application Brief and does not contain a detailed Experimental section.…
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Application Note Improved Oligonucleotide SPE-LC-MS Analysis Using MaxPeak High Performance Technology Kathryn Brennan, Mary Trudeau Lame, Michael Donegan, Paul D. Rainville Waters Corporation Abstract The demand for highly selective and sensitive LC-MS bioanalytical assays in support of research and development…
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