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Advances in Orbitrap Instrumentation for Native Top-Down Analysis of Non-Covalent Protein Complexes

 

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TECHNICAL NOTE 65379 Advancing native top-down MS analysis of non-covalent protein complexes: The Thermo Scientific Q Exactive UHMR mass spectrometer Authors Eugen Damoc, Kyle Fort, Maria Reinhardt-Szyba, Mikhail Belov, Alexander Makarov; Thermo Fisher Scientific, Bremen, Germany Rosa Viner; Thermo Fisher…
Key words
uhmr, uhmrnative, nativeabundance, abundancerelative, relativemass, massexactive, exactivesubunits, subunitsprotein, proteintop, topdown, downspectrometer, spectrometerions, ionsflatapole, flatapoleorbitrap, orbitrapheteromeric
Thermo Scientific Q Exactive UHMR Hybrid Quadrupole-Orbitrap mass spectrometer
2018|Thermo Fisher Scientific|Brochures and specifications
Go beyond what you thought possible with native MS Thermo Scientific Q Exactive UHMR Hybrid Quadrupole-Orbitrap mass spectrometer Gain deeper insight into native proteins Native mass spectrometry (MS) is a powerful technique for studying the structure of large protein complexes,…
Key words
uhmr, uhmrnative, nativerelative, relativeabundance, abundancemembrane, membraneexactive, exactivemass, massprotein, proteincomplexes, complexesproteins, proteinsflatapole, flatapolequadrupole, quadrupolethermo, thermotop, topdown
PRODUCT SPECIFICATIONS Q Exactive UHMR Hybrid Quadrupole-Orbitrap mass spectrometer Delivering unmatched identification and characterization Keywords Orbitrap technology, Q Exactive family, accurate mass, high resolution, native ms, ultra-high mass range Benefits • U  ltra-high mass range up to m/z 80,000…
Key words
uhmr, uhmrtrapping, trappingorbitrap, orbitrapexactive, exactivetransmission, transmissionmass, masshcd, hcdion, ionsource, sourceaqt, aqtquadrupole, quadrupolenanospray, nanosprayadvanced, advancedflow, flowhyperquad
ex ex co filter in a quadrupole-Orbitrap hybrid Mass Spectrometer Results: Viability of the concept is explored using simulation and initial experiments FI m Introduction Recent advances in top-down analysis of intact proteins were largely driven by improving of liquid…
Key words
gate, gatebouncer, bouncerhcd, hcdflight, flightselection, selectiondecelerator, deceleratorthebouncer, thebouncerpulser, pulserintact, intacttrap, trapcontinuousbeam, continuousbeamdutycycle, dutycycleinjectionflatapole, injectionflatapolelayoutofofthe, layoutofofthedeflection
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