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Complete characterization of monoclonal antibodies under native and denaturing conditions

Applications | 2021 | Thermo Fisher ScientificInstrumentation
LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap
Industries
Pharma & Biopharma
Manufacturer
Thermo Fisher Scientific
Key words
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Comprehensive Characterization of Monoclonal Antibody and Antibody Drug Conjugate on a Hybrid QuadrupoleOrbitrap Mass Spectrometer Kristina Srzentić1, Eugen Damoc2, Krisztina Radi3, Tom Buchanan3 , Angela Criscuolo2, Jennifer Sutton1 1Thermo Fisher Scientific, Massachusetts, US, 2Thermo Fisher Scientific, Germany, and 3Thermo Fisher…
Key words
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RES MS analysis of antibodies at the protein and peptide levels is critical during development and production of biopharmaceuticals. The compositions of current generation therapeutic proteins are often complex due to their heterogeneity caused by various modifications which are relevant…
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abundance, abundancelys, lystrastuzumab, trastuzumabrelative, relativeinfliximab, infliximabdisulfide, disulfidenative, nativebevacizumab, bevacizumabzoom, zoomxtract, xtractslslspgkc, slslspgkcslslspg, slslspgchain, chainintact, intactreduced
A comprehensive CE/ESI-MS solution for BioPharma applications Thermo Scientific Q Exactive hybrid quadrupole-Orbitrap mass spectrometers with ZipChip system Fast CE Separation Nanospray Sensitivity HRAM Spectrometry A unique and powerful combination of CE/ESI and MS technology designed for BioPharmaceutical applications Thermo…
Key words
zipchip, zipchipbiopharma, biopharmaexactive, exactiverelative, relativeabundance, abundancefinder, findermab, mabmass, massemtasine, emtasineoption, optionlysine, lysinetrastuzumab, trastuzumabcarbohydrates, carbohydratesides, idesinfliximab
Assessing Oxidation in IgG1 Monoclonal Antibodies and Correlating at both Intact Protein and Peptide Levels Tom Buchanan1, Sara Carillo2, Kristina Srzentić3, Kai Scheffler4, Angela Criscuolo4, Silvia Millan Martin2, Jennifer Sutton5, Phil Widdowson1, Ken Cook1, Jonathan Bones2. 1Thermo Fisher Scientific, Hemel,…
Key words
ipilimumab, ipilimumabgolimumab, golimumabdtlmisr, dtlmisrintact, intactcontrol, controlstressed, stressedδmass, δmasssubunit, subunitabundance, abundancehcd, hcdrelative, relativeunmodified, unmodifiedfull, fullmin, minpeptide
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