EXTREVA ASE Accelerated Solvent Extractor

Significance of the topic

Efficient and reproducible sample preparation underpins the reliability of chromatographic and mass spectrometric analyses. As instrumentation continues to advance, the bottleneck often shifts to laborious and error-prone sample handling. Streamlined, automated workflows not only improve data quality but also reduce costs and support sustainability targets by minimizing solvent consumption.

Objectives and study overview

This document presents the Thermo Scientific™ EXTREVA™ ASE™ Accelerated Solvent Extractor, designed to transform traditional extraction methods. The system aims to deliver true walk-away sample-to-vial preparation, boost throughput through parallel processing, and enhance reproducibility while cutting labor and solvent costs.

Methodology and instrumentation

The EXTREVA ASE employs accelerated solvent extraction combined with dynamic gas-assisted extraction to achieve rapid, efficient recovery of analytes. Up to four samples are processed simultaneously in a single run, with automated solvent delivery, extraction, evaporation, and vial transfer. Key features include:

• Parallel extraction modules for high sample throughput
• Automated concentration and vial filling
• Dynamic gas-assisted mode to lower solvent usage
• Intuitive software for method setup and monitoring

Main results and discussion

Implementation of the EXTREVA ASE system yields:

• Enhanced reproducibility and recovery: Reduced operator variability leads to consistent results.
• Increased throughput: Four-sample parallel extraction cuts total processing time by up to 75% compared to single-sample methods.
• Cost reductions: Automated workflows lower labor demands and solvent purchases, supporting laboratory sustainability goals.
• Error minimization: Walk-away operation decreases risk of manual mistakes and repeat analyses.

Benefits and practical applications of the method

The EXTREVA ASE platform is well suited for environmental, food safety, pharmaceutical, and QA/QC laboratories where high-volume extraction and reliable quantitation are critical. Primary advantages include:

• Reduced hands-on time, freeing analysts for priority tasks
• Standardized workflows that simplify analyst training
• Lower operational costs through decreased solvent use and waste disposal
• Scalable performance to adapt to varying sample loads

Future trends and potential applications

Emerging directions for automated extraction technologies include integration with online detectors (e.g., LC-MS/MS), adoption of greener solvent systems, miniaturization for microscale workflows, and the application of IoT and AI-driven process optimization. These advances promise even greater efficiency, traceability, and adaptability to complex sample matrices.

Conclusion

The Thermo Scientific EXTREVA ASE Accelerated Solvent Extractor addresses key challenges in modern sample preparation by offering a fully automated, parallel extraction solution. Laboratories can achieve significant gains in throughput, reproducibility, and sustainability, enabling analysts to focus on data interpretation rather than manual processing.

References

No references provided.