800 Dosino

Importance of the Topic

Precise and reproducible liquid handling is foundational in modern analytical chemistry. Automated dosing systems improve workflow efficiency, minimize operator error and chemical consumption, and ensure consistent results in titration, sample preparation and routine dosing tasks. The 800 Dosino combined with Metrohm dosing units addresses these needs by integrating high-resolution electronic control with minimal dead volume, promoting safety and versatility in laboratory and industrial environments.

Objectives and Overview

This manual provides a comprehensive description of the 800 Dosino dosing drive, its compatibility with Metrohm 807 Dosing Units, and the step-by-step procedures for installation, operation and maintenance. The primary goal is to guide users through setup, reagent handling, port configuration and troubleshooting to deploy the system effectively for buret-based titrations and complex liquid handling workflows.

Instrumentation

• 800 Dosino electronic dosing drive with integrated On and Status LEDs and MSB interface
• 807 Dosing Units with interchangeable cylinders (2, 5, 10, 20, 50 mL) featuring data chips for calibration and reagent information
• Compatible Metrohm control devices (Titrando models), Sample Processor adapters, and various bottle and canister thread adapters
• Accessories: bottle holders, support assemblies, piston tongs for maintenance

Methodology

Attach the 800 Dosino to a dosing unit by aligning guide pins and locking the green rib into the UNLOCK position, then rotating to LOCK. Port selection is achieved by rotating the stopcock via the drive pin, directing fluid between fill (Port 2), dosing (Port 1) and auxiliary ports. The electronic drive executes high-resolution piston movements (10 000 steps per stroke) for precise aspiration and dispensing. Reagent exchange uses automated EMPTY and PREP routines to evacuate and rinse the cylinder with minimal manual intervention. Maintenance routines include periodic inspection, cleaning of valve discs and data chip contacts, and professional calibration under GLP guidelines.

Main Results and Discussion

The 800 Dosino demonstrates reliable performance across a range of volumes with accuracies meeting ISO/DIN 8655-3 standards. Interchangeable dosing units with integrated data chips streamline reagent management and documentation. The low internal volume design reduces waste and prevents carryover. The simple mechanical coupling enables rapid reagent changes without tools, while the compact footprint conserves bench space. LED indicators and MSB communication provide intuitive status feedback and secure data exchange between instrument and control software.

Benefits and Practical Applications

• Automated titrations and routine dosing with consistent results and traceable calibration data
• Flexible integration into existing Metrohm systems (Titrando, Sample Processors) for expanded automation
• Enhanced safety: drive located above reagent bottle, sealed ports and vacuum-compensated supply
• Reduced reagent consumption and waste through minimal dead volume and automated rinsing
• Ease of use: quick swapping of dosing units and simple maintenance procedures

Future Trends and Applications

Advances in digital connectivity may enable remote monitoring and cloud-based calibration tracking. Integration with laboratory information management systems (LIMS) can streamline data documentation and compliance. Development of novel sensor-driven feedback loops could further refine dosing accuracy. Expansion of dosing unit volumes and materials compatible with a broader range of chemistries will extend applicability to emerging analytical challenges.

Conclusion

The 800 Dosino and associated dosing units offer a versatile, high-precision solution for automated liquid handling and titration tasks. Their user-friendly design, minimal maintenance requirements and strong integration capabilities make them an essential tool for laboratories seeking to improve efficiency, reproducibility and safety in analytical workflows.