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Automated High-Throughput N-Glycan Labelling and LC-MS Analysis for Protein A Purified Monoclonal Antibodies

 

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[APPLICATION NOTEBOOK] At-line Solutions for Upstream Bioprocessing Application Notes [APPLICATION NOTEBOOK] Introduction Bioprocessing harnesses the power of living cells to manufacture valuable products such as biological drugs for clinical use. The introduction and use of biologics has revolutionized biotherapeutics to…
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Application Note Automated High-Throughput AnalyticalScale Monoclonal Antibody Purification Using Production-Scale Protein A Affinity Chromatography Resin Stephan M. Koza, Caitlin M. Hanna, Albert H. W. Jiang, Ying Qing Yu Waters Corporation Abstract An automated analytical-scale Protein A affinity based purification of…
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Application Note Automated RapiFluor-MS Labeled Glycan Sample Preparation for Disulfide-Rich Glycoprotein Yamin Htet, Stephan M. Koza Waters Corporation Abstract N-glycans are routinely monitored for the quality of biotherapeutics because they affect the safety and efficacy of many therapeutic proteins. Current…
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BIOPHARMACEUTICAL PLATFORM SOLUTION Key Applications TABLE OF CONTENTS Biopharmaceutical Platform Solution with UNIFI: Key Applications Intact Protein MS Analysis I Peptide Mapping I Released Glycan Analysis I Bioseparations Biotherapeutic proteins – such as monoclonal antibodies (mAbs), biosimilars, and antibody drug…
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