Guided Resource Map - Agilent 708-DS Dissolution Apparatus

Significance of the Topic

Dissolution testing is a cornerstone of pharmaceutical development and quality control, ensuring that oral dosage forms release active ingredients at the correct rate and extent. Reliable and standardized dissolution methods are critical for regulatory compliance, product development, and batch release decisions.

Study Objectives and Overview

This document presents the Agilent 708-DS Dissolution Apparatus and the Agilent 850-DS Dissolution Sampling Station as a cohesive solution for both manual and fully automated dissolution workflows. Key goals include demonstrating instrument versatility, compliance with pharmacopeial standards, and streamlined sampling procedures.

Methodology and Instrumentation

The Agilent 708-DS features a modular design supporting 6 or 8 vessel positions with interchangeable paddles and baskets, PTFE-coated or electropolished stainless steel components, and a range of vessel sizes from 250 mL to 1 L. Advanced options include automated dose delivery, in-vessel temperature monitoring, automated sampling, and fiber-optic in situ analysis.

The Agilent 850-DS integrates seamlessly for unattended sampling and cleaning. Critical sampling parameters are adjustable to match method requirements:

• Prime volume: 4 to 25 mL to ensure line filling before sample pull
• Purge volume: 6 to 25 mL to clear previous sample and avoid dilution
• Waste drop: 0.2 to 10 mL to flush needles before collection
• Aspiration dwell time: 1 to 5 s, with at least 3 s for filter modules
• Pump speed: 6, 8, 10, or 12 mL/min, tailored for media viscosity
• Prime loss volume: 4 to 7 mL accounting for tubing and cannula volume

Accessories include UHMWPE filters, various basket shafts, TruAlign vessels, bent cannulas, sinks and sinkers, and Chinese Pharmacopeia kits.

Main Results and Discussion

Combined operation of the 708-DS and 850-DS yields consistent, pharmacopeia-compliant dissolution profiles. Automated sampling reduces manual variability, enhances throughput, and improves data integrity. Self-cleaning and volume calibration procedures further maintain accuracy over extended use.

Benefits and Practical Applications

• Flexible configuration for research, development, or QC labs
• High-throughput sampling using HPLC vials or 96-well plates
• Unattended operation increases productivity and reduces analyst error
• Pharmacopeial compliance for USP and international standards

Future Trends and Possibilities

Future developments may integrate real-time spectral monitoring, AI-driven method optimization, advanced materials for extended hardware longevity, and tighter digital integration with laboratory information management systems for end-to-end data traceability.

Conclusion

The Agilent 708-DS and 850-DS together deliver a robust, adaptable platform for comprehensive dissolution testing. Their combination of modular hardware, precise fluidics control, and automation capabilities addresses the evolving needs of pharmaceutical laboratories.

Reference

• No external references cited