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Confident and sensitive profiling of lipid nanoparticle raw materials and impurity identification using a LC/CAD/HRAM-MS method with inverse gradient

Applications | 2023 | Thermo Fisher ScientificInstrumentation
LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap
Industries
Pharma & Biopharma
Manufacturer
Thermo Fisher Scientific
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Application note | 000465 UHPLC-CAD Characterization of lipid nanoparticle (LNP) composition using UHPLC-CAD Authors Application benefits Sissi White1, Ken Cook 2, Mark Netsch3, • Simple UHPLC method for characterization of the lipid components of LNPs • Universal response shows relative…
Key words
lipid, lipiddspc, dspccholesterol, cholesterollnp, lnpmin, minarea, areadha, dhawithoffset, withoffsetamount, amountcad, cadlnps, lnpsvanquish, vanquishlipids, lipidsfisher, fisheruhplc
The role of universal detection in modern liquid chromatography Michael Heidorn September 21st, 2022 The world leader in serving science 1 [email protected] | 21-September-2022 What is universal detection? • A universal detector is characterized by providing a response for every…
Key words
cad, caduniversal, universaldspc, dspcdetector, detectordetectors, detectorslnps, lnpslnp, lnpvanquish, vanquishisq, isqlipid, lipiduhplc, uhplcinverse, inversepump, pumpbiontech, biontechmoderna
Th No er w m s o old Sc u ie nd nt e ifi r c th br e an d Analysis of Cationic Lipids Used as Transfection Agents for siRNA with Charged Aerosol Detection Gurmil Gendeh, Dionex Corporation,…
Key words
transfection, transfectioncationic, cationicdotma, dotmaddab, ddabsirna, sirnalipids, lipidsaerosol, aerosolchol, cholcharged, chargedagents, agentscad, cadminutes, minutescorona, coronadotap, dotapdope
Technical note | 002840 Biopharma Best practices for liposome analysis with the charged aerosol detector Application benefits Authors Susanne Fabel, Katherine Lovejoy, 1 1 • Using an ASTM method,1 lipids for liposomal formulations are quantified with calibration curves of each…
Key words
hspc, hspclog, logamount, amountlinearization, linearizationcad, cadcholesterol, cholesterolpow, powarea, areafit, fitinjections, injectionsdeviation, deviationvanquish, vanquishhydrogenated, hydrogenatedcurve, curvepower
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